Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.4.6 (
urease
)
7,490
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Trans-urocanic acid (trans-UCA) is synthesized in the skin, liver, and brain. It is a major natural moisturizing factor in skin and maintains its acid pH. In skin, it isomerizes to cis-
UCA
following exposure to UVR. Both isomers fulfill multiple roles in health and disease. Cis-
UCA
has immunomodulatory properties linked with several cutaneous diseases such as skin cancer, atopic dermatitis, and urticaria and associates with systemic diseases including
multiple sclerosis
. The levels of
UCA
in the skin, brain, urine, and feces reflect some physiological processes and may be disease biomarkers. Both isomers of
UCA
have therapeutic potential for a range of disorders.
...
PMID:The Multiple Roles of Urocanic Acid in Health and Disease. 3291 59
