Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:6.3.4.6 (urease)
 7,490 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We evaluated the diagnostic accuracy of endoscopic finding of nodular antritis and rapid urease test (RUT) in order to simplify the approach to the diagnosis of Helicobacter pylori (H. pylori) infection. Forty-four consecutive patients (mean age 7.9 yr, range 6-13 yr) referred because of recurrent abdominal pain as the main symptom, were prospectively investigated for the presence of H. pylori. H. pylori positivity or negativity was defined as the concordance of two of the following tests: RUT, microbiologic culture, and histologic examination on bioptic samples. RUT sensitivity was 100%, whereas specificity was 87.5%. The presence of nodular antritis had a sensitivity of 96.4% and specificity of 87.5% in H. pylori infection diagnosis. The predictivity value of combined RUT and nodular antritis, whether positive or negative, was 100%. Only in case of discordance do we suggest the utilization of other expensive tools for diagnosis of H. pylori infection.
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PMID:Helicobacter pylori infection: a simplified diagnostic approach. 188 14

The authors report the results of the detection of Helicobacter Pylori (HP) in gastric mucosa by the urease test, in 244 patients between January 1989 and August 1991. The overall prevalence of HP was 38.1%. It was 19.5% in patients with normal upper gastrointestinal endoscopy (UE), 61% in duodenal ulcer (p < 0.001) and 68.7% in congestive antritis (p < 0.001), significantly higher than in controls. There was no significant difference between controls and patients with erosive antritis or healed duodenal ulcers. The prevalence of HP rises with age in all patients and in those with lesions at UE but not in those with normal UE. A rise of this prevalence seems to exist in the months of June and December. The authors conclude by pointing out the rise of the overall prevalence of HP in congestive antritis compared with erosive antritis, the similarity of prevalence in normal subjects and those with healed ulcer and the lack of influence of age on this prevalence in subjects with normal UE. These conclusions are in need of confirmation by further studies on much more longer series.
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PMID:[Detection of Helicobacter pylori by the urease test in 244 patients]. 779 11

The aim of this study was to determine the prevalence of Helicobacter pylori (HP) infection in North Lebanon and to compare it with published figures. The study period was from September 1 1996 to March 31 1998. We tested 349 patients for HP, using biopsy tissue obtained by esophagoduodenoscopy and the modified urease technique. One hundred and seventy-nine of these patients were men and 170 were women. The mean age of the subjects was 39.3 years (range: 20 to 78 years). The prevalence of HP was 25.9% in individuals with normal endoscopy results (n = 104), 60.8% in patients with duodenal ulcer and 72% in patients with congestive antritis. The prevalence of HP in patients with erosive antritis was similar to that in individuals with normal endoscopy results. The prevalence of HP increased with age in the individuals with pathological endoscopic results but no such relationship was observed in individuals with normal endoscopy results. Our results show that the prevalence of HP in our patients is similar to that of industrialized countries. As age affected the prevalence of HP only in subjects with pathological endoscopy results, it is probably the extent of lesions caused by HP, rather than the infection itself, that increases with age.
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PMID:[++Helicobacter pylori infection in North Lebanon]. 1082 60