Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.4.6 (urease)
 7,490 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Helicobacter pylori causes human type B gastritis and is involved in the etiology of peptic ulcer disease. The routes of transmission of H. pylori are still unclear. The microorganism may be transmitted orally, since H. pylori has been detected in dental plaques. To confirm the hypothesis that dental plaques are a reservoir of H. pylori, 100 dental plaque specimens from 55 dental surgery patients were incubated on one nonselective and up to four selective agar media for the detection of H. pylori. In addition, urease activity of the plaque material was tested, and the gingival status of the patients was assessed. H. pylori was not cultivated from any of the specimens investigated. Plaque material from 12 patients with moderate and severe gingivitis showed urease activity. The results do not confirm the hypothesis that dental plaques are a relevant reservoir of viable H. pylori cells. However, non-cultivatable forms of H. pylori may survive in dental plaques. Urea cleaving activity of dental plaque may be a marker of gingival inflammation.
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PMID:No cultural detection of Helicobacter pylori in dental plaque. 780 25

General and dental status was evaluated in 64 children aged 5-14 years with active chronic gastroduodenitis and gastroduodenal ulcer. Helicobacter pylori was detected by the urease test and morphological analysis of gastric biopsy specimens with subsequent Giemsa or toluidine blue staining. The presence of Helicobacter pylori was confirmed by immunohistochemical analysis with monoclonal antibodies to this bacterium using DAKO kits. Children with gastroduodenal diseases often suffer from chronic catarrhal gingivitis liable to generalization and often develop pronounced changes in the mucosa of the tongue and red lips.
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PMID:[Status of oral mucosa and periodontal tissue in children with gastroduodenal diseases associated with Helicobacter pylori]. 1123 39

Helicobacter pylori is an important gastrointestinal pathogen associated with gastritis, peptic ulcers, and an increased risk of gastric carcinoma. The oral cavity has been indicated as a possible H. pylori reservoir, and may therefore be involved in the reinfection of the stomach which sometimes follows treatment of H. pylori infection. The objective of the present study was to evaluate the prevalence of H. pylori as detected by polymerase chain reaction (PCR) in the oral cavity of periodontitis patients testing positive for this bacterium in the stomach. Thirty adult patients with alterations of the superior digestive tract, testing urease positive after endoscopy and biopsy, were selected. A full-mouth periodontal examination was performed in every patient and the subjects were allocated to two groups: gingivitis (15 patients) and chronic periodontitis (15 patients). Plaque and saliva samples collected from each patient were stored in 0.5 ml of TE buffer. DNA was extracted from the samples by the boiling method and was evaluated for the presence of H. pylori using the PCR method. JW 22/23 primers were used. The DNA of ATCC H. pylori 43629 (positive control) and water (negative control) were used for controlling the reactions. Of the 30 evaluated patients, 13 (43.3%) harbored H. pylori in the mouth. The bacterium was not found on the dorsum of the tongue of any patient, but was found in saliva in three patients (10%), in the supragingival plaque in six patients (20%), and in the subgingival plaque in eight patients (26.6%). The presence of H. pylori was similar in the gingivitis and chronic periodontitis groups. In conclusion, a high percentage of patients harbored H. pylori in their mouth. The bacterium was detected in saliva, supragingival and subgingival plaque, suggesting that these sites may be considered reservoirs for H. pylori in urease-positive patients.
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PMID:Prevalence of Helicobacter pylori detected by polymerase chain reaction in the oral cavity of periodontitis patients. 1521

As introduced by different studies, dental plaque is known as a reservoir of Helicobacter Pylori (HP) and a potential source for gastric re-infection. Also, it has been demonstrated that individuals with gastric HP infection manifest a greater plaque index and a higher incidence rate for gingivitis. The goal of the present research was survey of severity and prevalence of periodontal diseases associated with gastric HP infection among patients having referred to the endoscopy wards of Imam Khomeini and Milad hospitals. In this research, 122 patients with gastric HP infection were investigated for determining 4 indices: plaque index (PI), gingival index (GI), clinical attachment loss (CAL) and pocket depth (PD), for all existing teeth, using RUT (rapid urease test). The results indicated that about 86.9% of patients had developed gingivitis of various degrees and 100% of them were afflicted with periodontitis of different degrees, and about 64.8% of patients showed a weak PI, and 61.5% had a low level of education. This low-level education seen in majority of the studied subjects, addresses a high degree of importance and influence of the oral hygiene in gastric HP infections. Hence, gastroentrologists are required to refer patients to dentists in line of preserving oral and dental health.
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PMID:Correlation between oral hygiene and Helicobacter pylori infection. 2113 68