Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:6.3.4.6 (urease)
 7,490 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prospective endoscopic study of 150 patients revealed chronic gastritis in 109 (72.6%), gastric ulcer in 6 (4%), chronic duodenitis in 9 (6%) and duodenal ulcer in 26 (17.4%). Searching for Helicobacter pylori, positive urease test was observed in 103 (68.67%), histologic evidence in 104 (69.33%) and positive serologic test in 98 (65.33%), without statistical difference. The urease test is recommended in the diary medical practice, for the patients who also will benefit themselves with the endoscopic diagnosis. On the other hand, the serologic test is useful when the endoscopy of the upper digestive tract cannot or must not be realized.
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PMID:[Helicobacter pylori and peptic disease: comparative study of the diagnostic methods]. 1885 58

The present study is done to study different aspects of Helicobacter pylori (H. pylori) such as its prevalence, association with upper gastrointestinal pathology, diagnosis and treatment outcome. Gastric antral biopsy and serology for H. pylori was done for all dyspeptic patients. Histopathology, gram stain and biopsy urease test was done from the gastric biopsy specimen. The prevalence of H. pylori infection was 58.8%. The sensitivity, specificity, positive and negative predictive value for histopathology was 96.9%, 100%, 100% and 95.8%, respectively; for biopsy urease test 80.4%, 100%, 100% and 78.2%, respectively; for gram stain 85.6%, 97.1%, 97.6% and 82.5%, respectively, and for serology 94.8%, 77.9%, 86% and 91.4%, respectively. Mostly peptic ulcer and duodenitis cases followed by chronic active gastritis were associated with H. pylori infection. Repeat biopsy revealed eradication of H. pylori in 90.7% cases. In dyspeptic patients, endoscopic biopsy not only detects H. pylori infection, but also reveals different gastric pathologies.
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PMID:Helicobacter pylori infection in dyspeptic patients in an industrial belt of India. 2677 10


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