Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:6.3.2.3 (glutathione synthetase)
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Human Gene/Protein
GSH synthetase 15.5
glutathione synthetase 15.1
Glutathione synthetase 14.8
gamma-glutamyl cyclotransferase 13.6
GSH2 13.5
5-oxoprolinase 13.3
GSH1 13.0
OPLAH 12.8
gamma-glutamylcysteine synthetase 12.5
GTR2 11.9
GLCLR 11.7
aromatic amino acid transporter 11.5
gamma-glutamylcyclotransferase 11.5
glutamate-cysteine ligase 11.3
ATG16L 11.3
GSS 11.2
HMT1 11.1
ERp18 11.1
GPX7 11.0
GSTA2-2 11.0
GCL 11.0
GSTM4 10.9
GST2 10.9
TNF-related apoptosis-inducing ligand receptor 2 10.9
aldehyde oxidase 1 10.8
tubulin-tyrosine ligase 10.8
SSAT1 10.8
peroxiredoxin 4 10.7
5-methyltetrahydrofolate-homocysteine methyltransferase 10.6
MAT2 10.6
riboflavin kinase 10.5
DNA damage-binding protein 2 10.5
PETA-3 10.4
biotin carboxylase 10.4
Glutamate-cysteine ligase 10.3
GSR 10.2
GST3 10.2
GAR transformylase 10.2
pristanoyl-CoA oxidase 10.2
GCLC 10.1
GGCT 10.1
GCSh 10.1
Rho GDP dissociation inhibitor alpha 10.1
maleylacetoacetate isomerase 10.0
GCS1 10.0
GSTZ1 10.0
GCLM 10.0
UDP-galactose-4-epimerase 10.0
adenosyltransferase 9.9
cysteine sulfinic acid decarboxylase 9.8
GCS 9.8
Pyruvate carboxylase 9.7
MsrB3 9.7
HBE1 9.6
peroxiredoxin 5 9.6
SEPT6 9.6
paraoxonase 2 9.5
SMYD2 9.5
TNFSF13B 9.5
NADP+-dependent isocitrate dehydrogenase 9.5
ARF7 9.5
pyrimidine 5'-nucleotidase 9.5
thioredoxin reductase 1 9.5
CDK3 9.4
SELL 9.4
copper transport protein 9.4
glutamate-cysteine ligase modifier subunit 9.4
UDP-N-acetylglucosamine pyrophosphorylase 9.4
neutrophil protein 9.3
CBX3 9.3
sulfate transporter 9.3
caveolin 3 9.3
choline dehydrogenase 9.3
ESM-1 9.3
FHL-1 9.2
cysteine desulfhydrase 9.2
GS-X 9.2
LIV-1 9.2
macrophage receptor with collagenous structure 9.2
APS kinase 9.2
FHC 9.2
GLYT1 9.2
mitochondrial carrier protein 9.1
Vanin-1 9.1
SVCT1 9.1
ATOX1 9.1
PICOT 9.0
glutathione peroxidase 4 9.0
GARS 9.0
S-adenosylmethionine synthetase 9.0
betaine-homocysteine methyltransferase 9.0
thioredoxin-like protein 8.9
CDO 8.9
DDAH 8.9
24 kDa protein 8.8
glutathione-dependent formaldehyde dehydrogenase 8.8
glutathione reductase 8.8
TMX 8.7
P1b 8.7
gamma-glutamyl transpeptidase 8.7
GRIP 8.7
phospholipid hydroperoxide glutathione peroxidase 8.7
Cystathionine gamma-lyase 8.6
ribosomal protein S3 8.6
GST1 8.6
GPX2 8.6
GSTO1 8.6
TP53-induced glycolysis and apoptosis regulator 8.5
Gamma-glutamyl transpeptidase 8.5
cystathionine-beta-synthase 8.5
endoplasmin 8.5
thioredoxin 2 8.5
neurosin 8.5
CYP4A11 8.5
GSH 8.4
fumarylacetoacetate hydrolase 8.4
glycogenin 8.4
RFT 8.4
HSP 90 8.4
ACC2 8.4
BNIP3L 8.3
GPX3 8.3
SAT1 8.2
S100A2 8.2
NRAMP1 8.2
gamma-glutamyltranspeptidase 8.2
ICAT 8.2
PC4 8.2
glyoxalase I 8.1
Kelch-like ECH-associated protein 1 8.1
S-adenosylhomocysteine hydrolase 8.1
cystathionine gamma-lyase 8.1
glutathione S-transferase pi 8.0
XDH 8.0
superoxide dismutase 1 8.0
ABCC3 8.0
collapsin response mediator protein 8.0
ATPase 6 8.0
SREBF1 7.9
p29 7.9
cysteine dioxygenase 7.9
PRIMA 7.9
pyridoxal kinase 7.8
ALAD 7.8
pyruvate dehydrogenase kinase 7.8
keratin 19 7.8
activating transcription factor 2 7.8
beta-lyase 7.7
RNO 7.7
GPX1 7.7
TRX 7.7
nuclear factor (erythroid-derived 2)-like 2 7.7
GLO1 7.7
mtTFA 7.7
adipose differentiation-related protein 7.6
methionine sulfoxide reductase 7.6
NRF-1 7.6
AMPS 7.6
long-chain acyl-CoA dehydrogenase 7.6
GSTA1 7.6
more...
Disease
Gamma-glutamylcysteine synthetase deficiency 15.5
gamma-Glutamyl transpeptidase deficiency 15.5
5-Oxoprolinuria 14.9
5-Oxoprolinase deficiency 14.5
GCS1 9.9
Krabbe disease 8.7
gastric neoplasm 8.5
GSH 8.4
Tietze 7.7
drug-induced hepatitis 7.5
PARK7 7.5
RSI 7.5
hemolytic anemia 7.3
AIDS-related Kaposi's sarcoma 7.2
GCE 7.0
potassium deficiency 7.0
Tuberculous meningitis 7.0
chronic phase CML 7.0
bubonic plague 6.9
aminoaciduria 6.8
Familial hypercholesterolemia 6.7
homocystinuria 6.6
LMS 6.6
LMS 6.6
comedo 6.5
ATD 6.4
chlorosis 6.4
NCR 6.4
cystinosis 6.3
Focal segmental glomerulosclerosis 6.3
cystinuria 6.2
GSD 6.2
G6PD deficiency 6.1
PCS 6.0
Hepatotoxicity 6.0
recurrent cancer 5.9
Zellweger syndrome 5.9
galactosemia 5.9
CLN3 5.9
laryngeal squamous cell carcinoma 5.8
kwashiorkor 5.8
folate deficiency 5.8
LMS 5.6
PCC 5.6
cystoid macular edema 5.6
PAL 5.4
AGS 5.4
CHS 5.3
veno-occlusive disease 5.3
LTD 5.3
hereditary hemochromatosis 5.2
tubular necrosis 5.2
enzyme deficiency 5.1
neoplastic process 5.0
adenocarcinoma of the lung 4.9
AIN 4.9
Fanconi syndrome 4.8
Nonalcoholic fatty liver 4.8
cancer recurrence 4.7
hyperbilirubinemia 4.7
immunotoxicity 4.6
renal tubular acidosis 4.5
Fanconi 4.5
lactic acidosis 4.5
CEM 4.5
macular edema 4.5
WRN 4.4
enterocolitis 4.4
varicocele 4.4
MDS 4.3
pheochromocytoma 4.3
metabolic disorder 4.2
hypercalciuria 4.2
HSP 4.2
atrophic gastritis 4.2
African trypanosomiasis 4.0
genetic disorder 4.0
iron overload 3.9
hyperhomocysteinemia 3.8
lichen 3.8
macular degeneration 3.7
ductal carcinoma 3.7
ductal carcinoma in situ 3.6
urolithiasis 3.6
myeloid leukemia 3.6
Blocking 3.4
ABL 3.4
MAS 3.3
leiomyosarcoma 3.3
neoplastic transformation 3.2
retinitis pigmentosa 3.2
male infertility 3.1
cataract 3.0
myelosuppression 3.0
pyelonephritis 2.9
renal impairment 2.9
amyotrophic lateral sclerosis 2.9
small cell lung cancer 2.9
ATM 2.9
NAME 2.8
polio 2.8
neuroblastoma 2.8
PCP 2.7
duodenal ulcer 2.7
prematurity 2.7
malnutrition 2.7
leukopenia 2.7
glomerulosclerosis 2.6
solid tumor 2.6
liver disease 2.6
metastatic breast cancer 2.6
head and neck cancer 2.6
developmental delay 2.5
WT1 2.5
diabetic retinopathy 2.5
Chagas 2.5
neutropenia 2.4
hepatocellular carcinoma 2.4
chronic liver disease 2.4
neurological disease 2.4
Alzheimer's disease 2.3
cholestasis 2.3
pulmonary tuberculosis 2.3
Yersinia 2.3
plague 2.2
ICP 2.2
SDS 2.2
primary tumor 2.2
glioma 2.2
peripheral neuropathy 2.2
multiple sclerosis 2.1
ventricular hypertrophy 2.1
gastroenteritis 2.0
alcohol abuse 2.0
liver cancer 2.0
sickle cell disease 2.0
myopathy 2.0
metabolic syndrome 2.0
brain tumor 2.0
dental caries 1.9
Brown 1.9
periodontitis 1.9
leishmaniasis 1.9
encephalomyelitis 1.9
anemia 1.9
sepsis 1.8
cold 1.8
bacteremia 1.8
Huntington's disease 1.8
fatty liver 1.8
Down syndrome 1.7
colon cancer 1.7
sepsis 1.7
myelodysplastic syndrome 1.7
malaria 1.7
Leukemia 1.6
liver cancer 1.6
Haemophilus 1.6
lupus 1.6
mental retardation 1.6
more...
Symptom
Anoxia 6.4
chills 3.5
hepatosplenomegaly 3.4
ataxia 3.1
splenomegaly 2.3
acidity 1.6
starvation 0.9
collapse 0.7
abdominal pain 0.6
vomiting 0.6
diarrhea -0.3
seizures -0.8
pain -2.5
Drug
Indisulam 11.7
Bucillamine 10.2
Glutathione 9.8
Tiopronin 9.4
Trypanothione 8.6
Glucantime 7.6
Primaquine 7.6
Areca 7.4
Bestatin 7.4
Bortezomib 6.6
Xanthium 5.8
ascorbate 5.5
CoCl2 5.2
CoCl2 5.2
Arsenic trioxide 5.2
ZnCl2 5.2
ZnCl2 5.2
balanced salt solution 4.9
vitamin E 4.9
ROS 4.6
NAG 4.4
MDS 4.4
CDP 4.3
TAT 4.3
pyridoxal phosphate 4.2
Alanine 4.1
citric acid 3.3
Angiotensin II 3.2
NADH 3.1
THF 2.5
ABC 2.4
Ethanol 2.3
Asn 2.0
CSF 1.6
lysine 1.3
caffeine 1.1
Leaf 1.1
IL-2 0.7
Cardiovasc -2.1
Enzyme
glutathione synthetase 15.5
homoglutathione synthetase 14.7
5-oxoprolinase 13.0
gamma-glutamylcyclotransferase 12.5
gamma-glutamylcysteine synthetase 12.2
malate thiokinase 12.2
D-alanine:D-alanine ligase 12.1
phytochelatin synthase 11.5
D-cysteine desulfhydrase 11.5
cysteine synthase 10.9
biotin carboxylase 10.7
tubulin-tyrosine ligase 10.6
glycinamide ribonucleotide transformylase 10.3
ATP sulfurylase 10.0
ribulose 5-phosphate 3-epimerase 10.0
PAPS reductase 9.9
desulfhydrase 9.8
UDP-N-acetylglucosamine pyrophosphorylase 9.7
riboflavin kinase 9.5
serine acetyltransferase 9.4
threonine aldolase 9.3
dihydroxyacetone kinase 9.3
choline dehydrogenase 9.2
APS reductase 9.2
betaine-homocysteine methyltransferase 9.2
dehydroascorbate reductase 9.0
PTR1 8.8
glutathione reductase 8.8
sulfite reductase 8.7
sulfite reductase 8.7
sulfite reductase 8.7
polyphosphate kinase 8.7
APS kinase 8.7
LTC4 synthase 8.6
tripeptidase 8.5
succinyl-CoA synthetase 8.4
trehalose synthase 8.4
fumarylacetoacetate hydrolase 8.3
glycogenin 8.3
xylulokinase 8.1
cystathionine gamma-lyase 8.1
phospholipid hydroperoxide glutathione peroxidase 8.1
glucosidase II 8.0
adenylosuccinate lyase 8.0
cystathionine beta-synthase 7.9
betaine aldehyde dehydrogenase 7.9
pyridoxal kinase 7.7
cysteine dioxygenase 7.7
gamma-glutamyl transpeptidase 7.7
methionine adenosyltransferase 7.7
ADE2 7.7
acetate kinase 7.6
methionine sulfoxide reductase 7.6
SOR 7.6
formaldehyde dehydrogenase 7.6
glyoxalase II 7.6
xylitol dehydrogenase 7.4
biliverdin reductase 7.4
xylitol dehydrogenase 7.4
dimethylarginine dimethylaminohydrolase 7.3
carbamoylphosphate synthetase 7.2
inulinase 7.2
MsrA 7.2
spermidine synthase 7.1
SCS 7.1
trypanothione reductase 7.0
inulinase 7.0
glutathione peroxidase 6.9
ascorbate peroxidase 6.9
GLO 6.9
methionine synthase 6.8
MDP 6.7
methionine synthase 6.7
lactonase 6.7
polyamine oxidase 6.7
asparagine synthetase 6.6
arginine decarboxylase 6.5
CDH 6.4
serine hydroxymethyltransferase 6.3
heme oxygenase 6.3
arginine decarboxylase 6.2
NQO1 6.2
acyl-CoA dehydrogenase 6.0
PDK1 6.0
glutathione S-transferase 6.0
sucrose synthase 5.9
acyl-CoA dehydrogenase 5.9
thioredoxin reductase 5.8
pyruvate decarboxylase 5.8
phosphoenolpyruvate carboxylase 5.8
pyruvate dehydrogenase 5.8
pyruvate dehydrogenase 5.7
peroxiredoxin 5.7
ALDH 5.7
catalase 5.6
glutaminase 5.6
acetyl-CoA carboxylase 5.6
acyl-CoA oxidase 5.6
diacylglycerol kinase 5.6
sorbitol dehydrogenase 5.5
superoxide dismutase 5.5
pyruvate dehydrogenase 5.4
glucose-6-phosphate dehydrogenase 5.4
CPS 5.2
transketolase 5.2
carboxypeptidase Y 5.2
pyruvate kinase 5.2
rubisco 5.1
aequorin 5.0
transpeptidase 5.0
ribonucleotide reductase 5.0
pyruvate carboxylase 5.0
PAL 4.9
aryl hydrocarbon hydroxylase 4.8
glutamine synthetase 4.8
phosphoglucose isomerase 4.8
NADPH oxidase 4.8
aldolase 4.8
hexokinase 4.7
nitrogenase 4.7
nitrite reductase 4.7
cathepsin K 4.7
enolase 4.7
arginase 4.7
PAM 4.7
NADPH oxidase 4.6
nitrite reductase 4.6
nitrite reductase 4.6
dihydrofolate reductase 4.6
adenylate kinase 4.6
phosphoenolpyruvate carboxykinase 4.5
phosphoenolpyruvate carboxykinase 4.5
PAL 4.5
NADH dehydrogenase 4.5
hormone-sensitive lipase 4.4
glutamate decarboxylase 4.4
phosphoglycerate kinase 4.4
aldehyde dehydrogenase 4.4
aldehyde dehydrogenase 4.4
soluble epoxide hydrolase 4.4
aldehyde dehydrogenase 4.4
CPT 4.4
phosphoenolpyruvate carboxykinase 4.3
TAT 4.3
aldehyde dehydrogenase 4.2
demethylase 4.1
firefly luciferase 4.1
ribonucleotide reductase 4.0
caspase-3 4.0
glucose-6-phosphatase 3.9
aldehyde dehydrogenase 3.8
CD10 3.8
AMP-activated protein kinase 3.8
aldose reductase 3.8
CD13 3.7
thymidylate synthase 3.7
nitrate reductase 3.7
nitrate reductase 3.7
nitrate reductase 3.7
nitrate reductase 3.7
more...
Compound
gamma-Glutamylcysteine 13.3
Ophthalmic acid 13.2
5-oxoproline 12.8
5-oxoproline 12.8
5-oxoproline 12.6
Methanofuran 12.5
5-oxoproline 12.3
3GC 12.1
Solasonine 12.1
L-Gulonolactone 10.9
2-AB 10.9
ECS 10.7
Buthionine sulfoximine 9.8
BSO 9.6
Carnosol 9.5
Isoproturon 9.5
TBHQ 9.2
O-acetylserine 9.0
O-acetylserine 8.8
Ethacrynic acid 8.8
Triphosphate 8.6
GSH 8.5
GSH 8.5
Ethacrynic acid 8.4
BNPP 8.4
GSSG 8.4
Chlorothalonil 8.4
O-acetylserine 8.4
Cys-Gly 8.2
isopropylbenzene 8.0
Monocrotaline 8.0
Fucoxanthin 8.0
Arecoline 7.8
Jasmonic acid 7.7
2-oxobutyrate 7.6
Primaquine 7.6
SKF 525A 7.5
Nitrofurantoin 7.3
LTA4 7.3
2-oxobutyrate 7.3
Bestatin 7.1
Safranin O 7.0
NOXA 7.0
Cysteine 6.8
norvaline 6.8
DDC 6.8
DDC 6.8
norvaline 6.7
dimethylarsinic acid 6.6
dimethylarsinic acid 6.6
dimethylarsinic acid 6.6
dimethylarsinic acid 6.6
D-Ala 6.6
dimethylarsinic acid 6.6
Imidacloprid 6.6
cysteine 6.5
Arsenate 6.5
BHC 6.5
ASN 6.5
DNFB 6.5
Cysteamine 6.5
dimethylarsinic acid 6.4
Glu-Glu 6.4
carbamyl phosphate 6.4
Arsenite 6.3
Safranin O 6.2
CDH 6.2
Methylglyoxal 6.1
Luteolin 6.1
bromobenzene 6.1
Dichloroacetate 6.1
APS 6.0
CdCl2 6.0
Polyamine 6.0
Epigallocatechin 5.9
N-acetylcysteine 5.9
DON 5.9
tert-butyl hydroperoxide 5.9
isobutyric acid 5.8
DDC 5.7
Suramin 5.7
cadmium 5.7
tetraphosphate 5.7
bis(2-chloroethyl) 5.6
LTC4 5.6
dihydrofolate 5.6
DPI 5.6
phthalaldehyde 5.6
bis(2-chloroethyl) 5.5
1-chloro-2,4-dinitrobenzene 5.5
beta-alanine 5.5
pentose 5.5
pentose 5.5
NPA 5.5
pentose 5.5
pentose 5.4
UMP 5.4
HEMA 5.4
LTD 5.3
glutamate 5.2
CoQ 5.2
MES 5.2
MES 5.2
DEN 5.2
PEA 5.1
Titanium dioxide 5.1
naphthoquinone 5.1
naphthoquinone 5.1
naphthoquinone 5.1
naphthoquinone 5.1
naphthoquinone 5.1
naphthoquinone 5.1
Lip 5.1
Acetone 5.1
Mato 5.0
HMG-CoA 5.0
DHA 5.0
naphthoquinone 5.0
bis(2-chloroethyl) 5.0
PDT 5.0
glutamic acid 5.0
Androgen 4.9
DHA 4.9
Arsenic 4.9
TAA 4.8
H2O2 4.8
2-nonenal 4.8
NADPH 4.7
NADPH 4.7
APAP 4.7
Gly 4.7
EDC 4.7
NAD 4.7
ATP 4.7
CBS 4.7
glutamine 4.6
Ascorbic acid 4.6
PCI 4.6
Photodyn 4.5
Photodyn 4.5
Photodyn 4.5
Photodyn 4.5
Photodyn 4.5
Photodyn 4.5
Photodyn 4.5
Photodyn 4.5
Photodyn 4.5
Photodyn 4.5
Photodyn 4.5
aminomethyl 4.5
Rifampicin 4.5
Glutamate 4.5
ABA 4.4
alanine 4.4
EMS 4.4
DHA 4.4
chromate 4.4
Hoechst 33342 4.3
aflatoxin B1 4.3
Photodyn 4.3
more...