Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.2.3 (
glutathione synthetase
)
678
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The role of indole-3-acetic acid (IAA) and hydrogen peroxide (H
2
O
2
) crosstalk in regulating metal stress is still less known. Herein, role of IAA in alleviating arsenate (As
V
) toxicity in brinjal seedlings along with its probable relation with endogenous H
2
O
2
was investigated.
Arsenate
hampered root growth due to greater accumulation of As and decrease in phosphorus uptake that resulted into inhibited photosynthesis and cell death. Further, As
V
induced oxidative stress markers and damage to macromolecules (lipids and proteins) due to alterations in redox status of glutathione as a result of inhibition in activity of
glutathione synthetase
and glutathione reductase. However, application of IAA with As
V
improved root growth by significantly declining As accumulation and oxidative stress markers, sequestrating As into vacuoles, and improving redox status of glutathione which collectively protected roots from cell death. Interestingly, addition of diphenylene iodonium (DPI, an inhibitor of NADPH oxidase) further increased As
V
toxicity even in the presence of IAA. However, application of H
2
O
2
rescued negative effect of DPI. Overall, the results suggested that in IAA-mediated mitigation of As
V
toxicity in brinjal roots, endogenous H
2
O
2
might have acted as a downstream signal.
...
PMID:Mitigation of arsenate toxicity by indole-3-acetic acid in brinjal roots: Plausible association with endogenous hydrogen peroxide. 3315 95
