Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.2.19 (ubiquitin-protein ligase)
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Human Gene/Protein
Ubiquitin-like modifier activating enzyme 1 15.3
ANKRD13A 15.3
KIAA0675 15.3
FBL7 15.3
hect domain and RLD 5 15.3
ubiquitin-protein ligase 15.3
ANKRD13D 15.3
Ubiquitin-protein ligase 15.3
ANKRD13B 15.3
Praja-1 14.7
C1QL4 14.3
KIAA0554 14.3
40S ribosomal protein S3a 14.3
5'-3' exoribonuclease 2 14.3
arrestin domain containing 4 14.3
NEDD4 protein 14.0
E2-F1 13.9
Cellular tumor antigen p53 13.7
RFPL4 13.7
DnaJ/Hsp40 chaperone 13.7
UFD2 13.7
ubiquitin-like modifier activating enzyme 3 13.7
DRIP1 13.7
RSP5 13.5
FBXO17 13.3
coactivator for steroid receptors 13.3
Ring finger protein 1 13.3
UBA6 13.3
sideroflexin 2 13.3
DRIP2 13.3
ZNF645 13.3
PMEPA1 protein 13.3
HIRIP3 13.3
CDC26 13.1
KDELR3 13.0
SMAX2 13.0
FKBP3 13.0
chromodomain helicase DNA binding protein 2 13.0
RNF128 13.0
WBP-1 13.0
TOP1 protein 13.0
Vaccinia-related kinase 3 13.0
EIF-5A 13.0
ubiquitin carrier protein 12.9
ADP-ribosylation factor domain protein 1 12.7
FBG3 12.7
RNF186 12.7
RNF206 12.7
arginyl-tRNA-protein transferase 12.7
UBC4 12.6
UBA1 12.5
seven in absentia homolog 2 12.5
FBXO27 12.5
ubiquitin thiolesterase 12.5
FBXO6 12.5
SWM1 12.5
HERC1 12.5
APC11 12.3
E6-AP 12.3
Multidrug resistance protein 3 12.3
CPSF7 12.3
AHNAK protein 12.3
heterogeneous nuclear ribonucleoprotein A3 12.3
CGR19 12.3
RNF26 12.3
UBE1 12.3
USE1 12.2
PHP2 12.1
VPS13D 12.1
nucleolar and coiled-body phosphoprotein 1 12.1
UBE1L 12.1
Ubiquitin-activating enzyme 12.1
ARRDC4 12.1
RuvB-like 2 12.1
TINO 12.1
TOMM22 12.1
PAIP1 12.1
EF1B 12.1
UbcH7 12.1
ARIH1 12.0
more...
Disease
SMAX2 13.3
Juvenile Parkinsonism 11.8
Liddle's syndrome 11.4
Staring 10.6
CRV 10.0
PARK1 9.9
Angelman syndrome 9.5
PARK2 9.3
NPHP3 9.1
adult brain tumor 8.7
PARK6 8.6
IBR 8.5
Azul 8.4
Dent's disease 8.0
riboflavin deficiency 7.1
Canavan 7.0
CYLD 6.9
XPB 6.9
brachycephaly 6.9
EBM 6.7
anal atresia 6.6
RP11 6.5
Heller 6.5
parkinsonism 6.3
AAA 6.3
PHP 6.3
LAP 6.1
language disorder 6.0
APC 6.0
OPA1 5.9
RP4 5.8
molluscum contagiosum 5.7
Spinocerebellar ataxia 5.7
NLS 5.6
Cholangiocarcinoma 5.5
RDA 5.5
Machado-Joseph disease 5.5
renal hypertension 5.5
leukodystrophy 5.4
chancroid 5.4
Cholangiocarcinoma 5.3
Anisakis 5.3
uterine cancer 5.2
synovial sarcoma 5.2
Hippel 5.1
limb-girdle muscular dystrophy 5.1
Cockayne syndrome 5.1
Parkinson's disease 4.9
severe mental retardation 4.8
DSS 4.8
abdominal aortic aneurysm 4.8
esophageal atresia 4.8
acute promyelocytic leukemia 4.7
plant disease 4.6
muscular atrophy 4.6
Japanese encephalitis 4.6
Dementia with Lewy bodies 4.6
papilloma 4.5
DSS 4.5
FBS 4.5
mantle cell lymphoma 4.5
ARF 4.3
erythroleukemia 4.3
pruritus 4.3
Autism spectrum disorder 4.3
amyotrophic lateral sclerosis 4.2
PML 4.2
adult T-cell leukemia/lymphoma 4.0
HGF 3.9
telangiectasia 3.9
viral diarrhea 3.9
developmental delay 3.9
Huntington's disease 3.9
tumorigenesis 3.9
oral cancer 3.8
coxsackievirus 3.8
achalasia 3.8
motor neuron disease 3.8
xeroderma pigmentosum 3.8
Blocking 3.7
more...
Symptom
ataxic gait 6.2
ataxia 3.6
starvation 3.5
cerebellar ataxia 3.5
hypotonia 2.8
dystonia 2.2
seizures 2.2
tremor 2.1
functional recovery 1.6
collapse 1.5
acidity 1.4
weakness 1.1
overweight 0.6
Drug
Parkin 9.8
Parkin 9.8
Jujube 9.1
Pirarubicin 8.8
Bortezomib 6.7
TAK 6.3
Dasatinib 6.0
GEO 5.7
CIA 5.7
AMC 5.1
CoCl2 5.0
CoCl2 5.0
Arsenic trioxide 5.0
Ginseng 4.6
lysine 4.5
CPT-11 4.4
uPA 4.2
Alanine 3.8
Heme 3.7
Taxol 3.6
Retinoic acid 3.6
Kenyan 3.5
Glutathione 2.9
ICI 2.9
nitroglycerin 2.2
caffeine 0.9
NADH 0.9
IL-2 0.4
CSF 0.4
Dermatol -2.7
Enzyme
ubiquitin-protein ligase 15.3
ubiquityl-calmodulin synthetase 13.9
5,10-methenyltetrahydrofolate synthetase 10.8
3-hydroxybutyryl-CoA dehydrogenase 9.6
aminopeptidase I 9.4
arginyl-tRNA synthetase 9.2
galactinol synthase 8.8
isopeptidase 8.7
3C protease 8.3
proteasome 8.0
type 1 protein phosphatase 7.9
S-adenosyl-L-homocysteine hydrolase 7.2
separase 6.9
m-calpain 6.6
IscS 6.5
trehalase 6.5
chorismate mutase 6.5
diacylglycerol kinase 6.3
p80 6.2
cysteine synthase 6.0
3-hydroxyacyl-CoA dehydrogenase 5.9
fatty acid desaturase 5.8
E-2 5.8
glycerol kinase 5.8
leucine aminopeptidase 5.6
TSP-1 5.6
APC 5.5
cystathionine beta-synthase 5.4
IKK 5.3
ECH 5.2
NADH dehydrogenase 5.2
3-hydroxy-3-methylglutaryl-CoA reductase 5.2
alpha-ketoglutarate dehydrogenase 5.0
transketolase 4.9
DNA ligase 4.9
DNA ligase 4.9
TOR 4.8
farnesyltransferase 4.7
protein phosphatase 2A 4.7
PNGase F 4.7
polo-like kinase 1 4.7
granzyme B 4.6
cdc2 4.6
enolase 4.4
glutaminase 4.4
cathepsin L 4.3
chaperonin 4.2
complex I 4.2
thioredoxin reductase 4.0
hexokinase 3.9
lysozyme 3.9
RNA polymerase 3.9
MDP 3.9
histone acetyltransferase 3.9
phosphoinositide 3-kinase 3.8
diaphorase 3.8
isocitrate dehydrogenase 3.7
protein kinase 3.7
transcriptase 3.7
ornithine decarboxylase 3.6
furin 3.6
ricin 3.6
glutathione S-transferase 3.6
beta-glucosidase 3.6
ribonuclease 3.6
ribonuclease 3.6
isocitrate dehydrogenase 3.5
aldolase 3.5
arginase 3.4
CaMKII 3.3
proteinase K 3.3
cathepsin D 3.3
heme oxygenase 3.2
MMP 3.2
calcineurin 3.2
RNase 3.1
PARP 3.1
topoisomerase 3.0
DNA methyltransferase 3.0
caspase-3 3.0
more...
Compound
Methyl caffeate 12.1
3-fluoropyridine 10.6
RUB 10.3
1,4-cyclohexanedione 9.7
Ubiquitin 9.3
Perillyl alcohol 9.2
Perillyl alcohol 9.2
Vinclozolin 9.1
PYR 8.8
Cbl 8.6
Embelin 8.4
Arabinogalactan 7.7
DGE 7.6
DGE 7.6
DGE 7.6
G 1 7.3
SSH 7.2
PPi 6.6
AICAR 6.6
CHIP 6.6
5-Azacytidine 6.5
DBT 6.4
Cortisone 6.4
AAA 6.3
AF-2 6.2
APH 6.1
DMPP 6.1
Glycogen synthase 6.1
Isoform 6.0
Arsenite 6.0
methanethiol 5.8
Uracil 5.7
AICAR 5.7
DEP 5.7
3-methylhistidine 5.7
Cycloheximide 5.6
MAD 5.6
Brefeldin A 5.6
Brefeldin A 5.6
adenylate 5.5
malononitrile 5.4
E-64 5.4
DEP 5.3
Artemisinin 5.3
SN-38 5.2
POP 5.0
isopentenyl diphosphate 4.9
40S 4.8
Guanine 4.8
lysine 4.7
CCP 4.6
Methamphetamine 4.6
Casein 4.5
myricetin 4.5
aldosterone 4.5
C2H2 4.5
CPT-11 4.4
ATF 4.4
DTT 4.3
DTT 4.2
DOC 4.2
BCNU 4.1
Vasopressin 4.1
Leucine 4.1
DPP 4.0
IAA 4.0
Arachidonic acid 4.0
DSS 4.0
ATP 4.0
Alanine 3.9
TNM 3.9
MMC 3.9
retinoic acid 3.9
IAA 3.8
GSSG 3.8
cysteine 3.8
pyrimidine 3.8
nicotinic acid 3.7
nicotinic acid 3.7
nicotinic acid 3.7
more...