Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.2.19 (ubiquitin-protein ligase)
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Human Gene/Protein
Ubiquitin-protein ligase 15.3
hect domain and RLD 5 15.3
FBL7 15.3
ANKRD13B 15.3
KIAA0675 15.3
Ubiquitin-like modifier activating enzyme 1 15.3
ubiquitin-protein ligase 15.3
ANKRD13A 15.3
ANKRD13D 15.3
Praja-1 14.7
C1QL4 14.3
5'-3' exoribonuclease 2 14.3
KIAA0554 14.3
40S ribosomal protein S3a 14.3
arrestin domain containing 4 14.3
NEDD4 protein 14.0
E2-F1 13.9
RFPL4 13.7
DnaJ/Hsp40 chaperone 13.7
UFD2 13.7
DRIP1 13.7
Cellular tumor antigen p53 13.7
ubiquitin-like modifier activating enzyme 3 13.7
RSP5 13.5
DRIP2 13.3
ZNF645 13.3
HIRIP3 13.3
coactivator for steroid receptors 13.3
sideroflexin 2 13.3
PMEPA1 protein 13.3
UBA6 13.3
FBXO17 13.3
Ring finger protein 1 13.3
CDC26 13.1
KDELR3 13.0
SMAX2 13.0
Vaccinia-related kinase 3 13.0
WBP-1 13.0
EIF-5A 13.0
FKBP3 13.0
more...
Disease
SMAX2 13.3
Juvenile Parkinsonism 11.8
Liddle's syndrome 11.4
Staring 10.6
CRV 10.0
PARK1 9.9
Angelman syndrome 9.5
PARK2 9.3
NPHP3 9.1
adult brain tumor 8.7
PARK6 8.6
IBR 8.5
Azul 8.4
Dent's disease 8.0
riboflavin deficiency 7.1
Canavan 7.0
CYLD 6.9
XPB 6.9
brachycephaly 6.9
EBM 6.7
anal atresia 6.6
RP11 6.5
Heller 6.5
parkinsonism 6.3
AAA 6.3
PHP 6.3
LAP 6.1
language disorder 6.0
APC 6.0
OPA1 5.9
RP4 5.8
molluscum contagiosum 5.7
Spinocerebellar ataxia 5.7
NLS 5.6
Cholangiocarcinoma 5.5
RDA 5.5
Machado-Joseph disease 5.5
renal hypertension 5.5
leukodystrophy 5.4
chancroid 5.4
more...
Symptom
ataxic gait 6.2
ataxia 3.6
starvation 3.5
cerebellar ataxia 3.5
hypotonia 2.8
dystonia 2.2
seizures 2.2
tremor 2.1
functional recovery 1.6
collapse 1.5
acidity 1.4
weakness 1.1
overweight 0.6
Drug
Parkin 9.8
Parkin 9.8
Jujube 9.1
Pirarubicin 8.8
Bortezomib 6.7
TAK 6.3
Dasatinib 6.0
GEO 5.7
CIA 5.7
AMC 5.1
CoCl2 5.0
CoCl2 5.0
Arsenic trioxide 5.0
Ginseng 4.6
lysine 4.5
CPT-11 4.4
uPA 4.2
Alanine 3.8
Heme 3.7
Taxol 3.6
Retinoic acid 3.6
Kenyan 3.5
Glutathione 2.9
ICI 2.9
nitroglycerin 2.2
caffeine 0.9
NADH 0.9
IL-2 0.4
CSF 0.4
Dermatol -2.7
Enzyme
ubiquitin-protein ligase 15.3
ubiquityl-calmodulin synthetase 13.9
5,10-methenyltetrahydrofolate synthetase 10.8
3-hydroxybutyryl-CoA dehydrogenase 9.6
aminopeptidase I 9.4
arginyl-tRNA synthetase 9.2
galactinol synthase 8.8
isopeptidase 8.7
3C protease 8.3
proteasome 8.0
type 1 protein phosphatase 7.9
S-adenosyl-L-homocysteine hydrolase 7.2
separase 6.9
m-calpain 6.6
IscS 6.5
trehalase 6.5
chorismate mutase 6.5
diacylglycerol kinase 6.3
p80 6.2
cysteine synthase 6.0
3-hydroxyacyl-CoA dehydrogenase 5.9
fatty acid desaturase 5.8
E-2 5.8
glycerol kinase 5.8
leucine aminopeptidase 5.6
TSP-1 5.6
APC 5.5
cystathionine beta-synthase 5.4
IKK 5.3
ECH 5.2
NADH dehydrogenase 5.2
3-hydroxy-3-methylglutaryl-CoA reductase 5.2
alpha-ketoglutarate dehydrogenase 5.0
transketolase 4.9
DNA ligase 4.9
DNA ligase 4.9
TOR 4.8
farnesyltransferase 4.7
protein phosphatase 2A 4.7
PNGase F 4.7
more...
Compound
Methyl caffeate 12.1
3-fluoropyridine 10.6
RUB 10.3
1,4-cyclohexanedione 9.7
Ubiquitin 9.3
Perillyl alcohol 9.2
Perillyl alcohol 9.2
Vinclozolin 9.1
PYR 8.8
Cbl 8.6
Embelin 8.4
Arabinogalactan 7.7
DGE 7.6
DGE 7.6
DGE 7.6
G 1 7.3
SSH 7.2
PPi 6.6
AICAR 6.6
CHIP 6.6
5-Azacytidine 6.5
DBT 6.4
Cortisone 6.4
AAA 6.3
AF-2 6.2
APH 6.1
DMPP 6.1
Glycogen synthase 6.1
Isoform 6.0
Arsenite 6.0
methanethiol 5.8
Uracil 5.7
AICAR 5.7
DEP 5.7
3-methylhistidine 5.7
Cycloheximide 5.6
MAD 5.6
Brefeldin A 5.6
Brefeldin A 5.6
adenylate 5.5
more...