Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.2.19 (ubiquitin-protein ligase)
 799 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ubiquitin-protein ligase 547
ubiquitin 433
proteasome 186
Mol 93
ubiquitin-conjugating enzyme 63
p53 59
Sep 59
Ubiquitin 55
ATP 52
ubiquitin ligase 51
Parkin 43
parkin 36
Nedd4-2 28
endoplasmic reticulum 27
E6-AP 25
ENaC 24
SCF 24
proteasome inhibitor 23
RSP5 22
cyclin 22
E3 ubiquitin ligase 21
UBE3A 20
E2 ubiquitin-conjugating enzyme 18
E6AP 18
UBC4 18
APC 16
tRNA 16
Skp1 13
E6 protein 12
ATPase 12
PINK1 11
alpha-synuclein 11
UbcH7 11
HERC1 11
F-box protein 11
polypeptide 11
cytokine 11
RNA polymerase II 10
NMR 10
ubiquitin carrier protein 10
more...
Disease
cancer 82
tumor 55
Parkinson's disease 46
parkinsonism 29
tumorigenesis 21
Angelman syndrome 20
breast cancer 16
APC 16
Liddle's syndrome 14
hypertension 14
lung cancer 12
carcinogenesis 10
amyotrophic lateral sclerosis 9
carcinoma 9
multiple myeloma 9
PARK2 8
Alzheimer's disease 8
dementia 8
cervical cancer 7
pruritus 7
adenocarcinoma 7
lymphoma 7
AAA 6
abdominal aortic aneurysm 6
Huntington's disease 5
MCF 5
tumor progression 5
muscular atrophy 5
mental retardation 5
autism 5
colorectal cancer 5
acute promyelocytic leukemia 5
mental retardation 5
non-small cell lung cancer 5
hepatocellular carcinoma 4
neuroblastoma 4
leukemia 4
virus infection 4
Hippel 4
lung carcinoma 4
more...
Symptom
seizures 9
starvation 7
ataxia 5
collapse 2
weakness 2
tremor 2
overweight 1
cerebellar ataxia 1
functional recovery 1
dystonia 1
ataxic gait 1
acidity 1
hypotonia 1
Drug
Parkin 43
Parkin 43
lysine 34
Bortezomib 4
TAK 2
GEO 2
uPA 1
Dermatol 1
Alanine 1
IL-2 1
Glutathione 1
CPT-11 1
CSF 1
Arsenic trioxide 1
caffeine 1
CIA 1
NADH 1
Dasatinib 1
Ginseng 1
Taxol 1
CoCl2 1
CoCl2 1
Jujube 1
Retinoic acid 1
Pirarubicin 1
ICI 1
AMC 1
nitroglycerin 1
Kenyan 1
Heme 1
Enzyme
ubiquitin-protein ligase 799
proteasome 188
protein kinase 26
APC 18
ERK 14
RNA polymerase 13
ATPase 12
mitogen-activated protein kinase 10
lysozyme 8
glutathione S-transferase 7
luciferase 7
caspase-3 7
isopeptidase 6
cdc2 5
IKK 5
protein kinase C 4
3C protease 4
RNase 4
calcineurin 4
complex I 4
ubiquityl-calmodulin synthetase 3
trypsin 3
focal adhesion kinase 3
PARP 3
transcriptase 3
superoxide dismutase 3
ornithine decarboxylase 2
diacylglycerol kinase 2
hexokinase 2
phospholipase C 2
protein phosphatase 2A 2
granzyme B 2
enolase 2
leucine aminopeptidase 2
arginyl-tRNA synthetase 2
DNA ligase 2
topoisomerase 2
diaphorase 2
NADH dehydrogenase 2
ribonuclease 2
more...
Compound
DNA 71
Dec 54
lysine 53
ATP 52
Ubiquitin 43
cysteine 26
sodium 26
Cbl 18
arginine 18
tyrosine 17
zinc 16
salt 16
serine 14
aldosterone 14
calcium 12
leucine 12
methionine 11
alanine 10
threonine 10
retinoic acid 9
glucose 9
nitrogen 9
water 8
NH2 8
AMP 8
His 8
Gly 8
adenylate 7
PYR 7
Clin 7
pyrimidine 7
Phe 6
sulfate 6
AAA 6
Ile 5
nitric oxide 5
PPi 5
cAMP 5
aldehyde 4
DEAE 4
more...