Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.2.19 (ubiquitin-protein ligase)
 799 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
FBL7 15.3
Ubiquitin-like modifier activating enzyme 1 15.3
hect domain and RLD 5 15.3
ANKRD13A 15.3
ANKRD13B 15.3
ANKRD13D 15.3
ubiquitin-protein ligase 15.3
KIAA0675 15.3
Ubiquitin-protein ligase 15.3
Praja-1 14.7
arrestin domain containing 4 14.3
C1QL4 14.3
KIAA0554 14.3
5'-3' exoribonuclease 2 14.3
40S ribosomal protein S3a 14.3
NEDD4 protein 14.0
E2-F1 13.9
Cellular tumor antigen p53 13.7
DnaJ/Hsp40 chaperone 13.7
RFPL4 13.7
ubiquitin-like modifier activating enzyme 3 13.7
DRIP1 13.7
UFD2 13.7
RSP5 13.5
PMEPA1 protein 13.3
HIRIP3 13.3
sideroflexin 2 13.3
UBA6 13.3
coactivator for steroid receptors 13.3
FBXO17 13.3
DRIP2 13.3
ZNF645 13.3
Ring finger protein 1 13.3
CDC26 13.1
Vaccinia-related kinase 3 13.0
WBP-1 13.0
TOP1 protein 13.0
chromodomain helicase DNA binding protein 2 13.0
KDELR3 13.0
RNF128 13.0
SMAX2 13.0
EIF-5A 13.0
FKBP3 13.0
ubiquitin carrier protein 12.9
ADP-ribosylation factor domain protein 1 12.7
RNF206 12.7
RNF186 12.7
arginyl-tRNA-protein transferase 12.7
FBG3 12.7
UBC4 12.6
UBA1 12.5
seven in absentia homolog 2 12.5
ubiquitin thiolesterase 12.5
FBXO6 12.5
FBXO27 12.5
SWM1 12.5
HERC1 12.5
APC11 12.3
E6-AP 12.3
RNF26 12.3
heterogeneous nuclear ribonucleoprotein A3 12.3
CGR19 12.3
AHNAK protein 12.3
CPSF7 12.3
Multidrug resistance protein 3 12.3
UBE1 12.3
USE1 12.2
TOMM22 12.1
PAIP1 12.1
VPS13D 12.1
UBE1L 12.1
RuvB-like 2 12.1
Ubiquitin-activating enzyme 12.1
ARRDC4 12.1
EF1B 12.1
PHP2 12.1
TINO 12.1
nucleolar and coiled-body phosphoprotein 1 12.1
UbcH7 12.1
ARIH1 12.0
rpl11 12.0
RNF139 12.0
NTKL 12.0
insulin induced gene 1 12.0
DZIP3 12.0
WW domain binding protein 2 12.0
Nedd4-2 11.9
CCNF 11.9
ubiquitin-conjugating enzyme 11.9
SALL4B 11.8
SPINK2 11.8
HELZ 11.8
RAI3 11.8
FBL3 11.7
UBP43 11.7
TRIM36 11.7
FBG1 11.6
E2 ubiquitin-conjugating enzyme 11.6
MDP1 11.6
MAGE-D 11.6
TPRD 11.6
MEX67 11.6
UbcH8 11.6
HACE1 11.6
cbl-b 11.5
Layilin 11.5
RTF1 11.5
E6TP1 11.5
RNF41 11.5
TRIP12 11.4
Doc1 11.4
Uba5 11.4
GRIP2 11.4
ubiquitin-fold modifier 1 11.4
APC8 11.4
CDC16 11.4
cdc2-related protein kinase 11.4
cyclin F 11.3
AIP2 11.3
E6AP 11.3
RING-IBR 11.3
MYCBP2 11.3
FAP48 11.2
CDC23 11.2
HBZ protein 11.2
Ubc6p 11.2
PCTK1 11.2
UBE2G2 11.2
PIRH2 11.2
WWP2 11.1
RING-H2 11.1
HSJ1a 11.1
Ufc1 11.1
LDOC1 11.1
SLC25A5 11.1
MTMR4 11.0
TMX1 11.0
ARAF1 11.0
PDZRN3 11.0
STAM-1 11.0
AGP1 11.0
UBE3A 11.0
UBA3 11.0
UBE2D1 11.0
Ubiquitin carboxyl-terminal hydrolase 11.0
NOT4 11.0
RNF144A 11.0
APC10 11.0
transformation/transcription domain-associated protein 11.0
UbcH6 10.9
UBR1 10.9
TRAIP 10.9
UBE3A protein 10.9
UBE2G1 10.9
PSMD1 10.9
RNF40 10.9
FAT10 10.8
UBE2O 10.8
YAP65 10.8
sigma 3 protein 10.8
FBXW8 10.8
formin-like 1 10.8
PDS5 10.8
UFM1 10.8
Pop1 10.7
SALL3 10.7
PICT-1 10.7
TRAF-interacting protein 10.6
VCY2 10.6
GORAB 10.6
MTHFS 10.6
APP-BP1 10.6
AKAP3 10.6
UHRF2 10.5
PSMD7 10.5
UBE2M 10.5
PSMD14 10.5
RNF216 10.5
UBE2H 10.5
UBA2 10.4
MMS2 10.4
ubiquitin-activating enzyme E1 10.4
SHFM3 10.4
NEDD4-2 10.4
UBE2L3 10.4
synphilin-1 10.4
ubiquitin-protein isopeptide ligase (E3) 10.4
AE4 10.4
PSMC4 10.3
Ubiquitin-conjugating enzyme 10.3
NPH3 10.3
sentrin-specific protease 10.3
RIG1 10.3
putative E3 ubiquitin ligase 10.3
TOPORS 10.2
TOM70 10.2
PSMA1 10.2
HNRNPK 10.2
kinase-like protein 10.2
UBC7 10.2
EEF2 10.1
RPS4X 10.1
HOIL-1 10.1
UBC2 10.1
parkin 10.1
cAMP responsive element modulator 10.1
GSPT1 10.1
HUWE1 10.0
myeloid zinc finger 1 10.0
NYGGF4 10.0
BRUCE 10.0
SRP14 10.0
E3 protein 10.0
UBR5 10.0
ubiquitin-like protein Nedd8 10.0
UBR4 10.0
NLRP2 10.0
NEDD4L 10.0
ubiquitin-protein isopeptide ligase 9.9
CSE1 9.9
RING finger protein 9.9
RBBP8 9.9
NEDD4 9.8
E6 protein 9.8
Parkin 9.8
HMGCS1 9.8
RPN2 9.8
FLRF 9.8
brca2 9.8
GPX7 9.8
ubiquitin-conjugating enzyme E2 9.8
LNX 9.8
PMEPA1 9.8
APC1 9.8
UBC9 9.7
Derlin-2 9.7
UQCRC1 9.7
TNF receptor-associated factor 3 9.7
RNF11 9.7
NDUFS2 9.7
USP22 9.7
elongin C 9.7
RING1A 9.6
GREM2 9.6
POSH 9.6
p53-binding protein 9.6
BI-1 9.6
HSD17B10 9.6
diubiquitin 9.6
Voltage-gated sodium channel 9.6
NEDD4-1 9.6
RING1 9.5
SPT6 9.5
PARKIN 9.5
NPI-1 9.5
Sharpin 9.5
RCC1-like 9.5
SFT 9.5
ring finger protein 9.4
RP-A 9.4
SRP9 9.4
SAE1 9.4
PTPRJ 9.4
Pellino 9.4
sperm surface protein 9.4
PTPRG 9.4
SUG1 9.3
TOP2B 9.3
PARK2 9.3
SKP2 9.3
+Ca 9.3
acrosin inhibitor 9.3
arginyl-tRNA synthetase 9.3
amino acid permease 9.3
DIAP1 9.3
Skp1 9.3
INSIG1 9.3
ARD1 9.3
NCK1 9.3
RBX1 9.2
CDC27 9.2
SAE2 9.2
IMPDH2 9.2
ribosomal protein L11 9.2
Cullin-1 9.2
Mule 9.2
TOM1 9.2
scribble 9.2
USP18 9.2
finger protein 9.2
par-4 9.2
DNAJB6 9.2
Grp170 9.2
CCR4-NOT 9.1
eps15 9.1
LRPPRC 9.1
TCR zeta chain 9.1
Sec62 9.1
TRIM21 9.1
MGD1 9.1
cell cycle-related protein 9.1
TPI1 9.1
ubiquitin 9.1
CRV 9.1
RNF43 9.0
1C5 9.0
XRN2 9.0
CHD2 9.0
securin 9.0
ubiquitin fusion protein 9.0
CDC20 9.0
BMP10 9.0
sentrin 9.0
cullin 3 9.0
Ubiquitin 9.0
RBP1 9.0
ORP150 9.0
USP10 9.0
EF1A 9.0
Ubc13 9.0
more...
Disease
SMAX2 13.3
Juvenile Parkinsonism 11.8
Liddle's syndrome 11.4
Staring 10.6
CRV 10.0
PARK1 9.9
Angelman syndrome 9.5
PARK2 9.3
NPHP3 9.1
adult brain tumor 8.7
PARK6 8.6
IBR 8.5
Azul 8.4
Dent's disease 8.0
riboflavin deficiency 7.1
Canavan 7.0
CYLD 6.9
XPB 6.9
brachycephaly 6.9
EBM 6.7
anal atresia 6.6
RP11 6.5
Heller 6.5
parkinsonism 6.3
AAA 6.3
PHP 6.3
LAP 6.1
language disorder 6.0
APC 6.0
OPA1 5.9
RP4 5.8
molluscum contagiosum 5.7
Spinocerebellar ataxia 5.7
NLS 5.6
Cholangiocarcinoma 5.5
RDA 5.5
Machado-Joseph disease 5.5
renal hypertension 5.5
leukodystrophy 5.4
chancroid 5.4
Cholangiocarcinoma 5.3
Anisakis 5.3
uterine cancer 5.2
synovial sarcoma 5.2
Hippel 5.1
limb-girdle muscular dystrophy 5.1
Cockayne syndrome 5.1
Parkinson's disease 4.9
severe mental retardation 4.8
DSS 4.8
abdominal aortic aneurysm 4.8
esophageal atresia 4.8
acute promyelocytic leukemia 4.7
plant disease 4.6
muscular atrophy 4.6
Japanese encephalitis 4.6
Dementia with Lewy bodies 4.6
papilloma 4.5
DSS 4.5
FBS 4.5
mantle cell lymphoma 4.5
ARF 4.3
erythroleukemia 4.3
pruritus 4.3
Autism spectrum disorder 4.3
amyotrophic lateral sclerosis 4.2
PML 4.2
adult T-cell leukemia/lymphoma 4.0
HGF 3.9
telangiectasia 3.9
viral diarrhea 3.9
developmental delay 3.9
Huntington's disease 3.9
tumorigenesis 3.9
oral cancer 3.8
coxsackievirus 3.8
achalasia 3.8
motor neuron disease 3.8
xeroderma pigmentosum 3.8
Blocking 3.7
gastrointestinal stromal tumor 3.7
metastatic melanoma 3.7
cervical cancer 3.7
mental retardation 3.7
mental retardation 3.6
hepatitis A 3.6
Rett syndrome 3.6
embryonal carcinoma 3.6
NS3 3.5
stromal tumors 3.5
azoospermia 3.5
cutaneous melanoma 3.4
retinoblastoma 3.4
pituitary adenoma 3.4
lymphoblastic leukemia 3.4
obsessive-compulsive disorder 3.3
multiple myeloma 3.3
choriocarcinoma 3.3
scrotum 3.3
CEM 3.2
hepatic encephalopathy 3.2
Still 3.2
Kaposi's sarcoma 3.2
non-small cell lung cancer 3.1
genetic disorder 3.1
neurological disease 3.1
MAS 3.1
Cushing's syndrome 3.1
HCG 3.0
respiratory failure 3.0
neoplastic transformation 3.0
renal cancer 3.0
vaccinia 2.9
male infertility 2.9
chronic lymphocytic leukemia 2.9
sleep disturbances 2.8
MCF 2.8
mimicry 2.8
muscular dystrophy 2.8
uremia 2.7
lung carcinoma 2.7
lung cancer 2.7
carcinoma in situ 2.7
aggressiveness 2.7
IVF 2.7
skin cancer 2.7
carcinogenesis 2.6
autism 2.6
mammary tumor 2.6
PDB 2.6
basal cell carcinoma 2.6
pancreatic cancer 2.5
neuroblastoma 2.5
Legionella 2.5
dementia 2.5
Pancreas 2.5
macular degeneration 2.5
chronic lymphocytic leukemia 2.5
Schistosoma mansoni 2.5
Pancreas 2.5
solid tumor 2.4
Melanoma 2.4
metastatic breast cancer 2.4
tumor progression 2.3
hematologic malignancies 2.3
liver fibrosis 2.3
WT1 2.3
myocarditis 2.2
periodontal disease 2.2
scoliosis 2.2
ulcerative colitis 2.2
glioblastoma multiforme 2.1
ICD 2.1
dilated cardiomyopathy 2.1
adenocarcinoma 2.0
breast cancer 2.0
lymphoma 1.9
colorectal cancer 1.9
squamous cell carcinoma 1.9
SCID 1.9
epithelial ovarian cancer 1.8
subarachnoid hemorrhage 1.8
Epstein 1.7
hypertension 1.7
virus infection 1.7
Brown 1.7
tumor 1.7
periodontitis 1.7
cystic fibrosis 1.7
SDS 1.7
ATM 1.6
cancer 1.6
Autism 1.5
dermatitis 1.5
Alzheimer's disease 1.5
dyslipidemia 1.5
herpes simplex 1.5
bipolar disorder 1.5
prostate cancer 1.4
glioma 1.4
pancreatitis 1.3
dysplasia 1.3
worms 1.2
carcinoma 1.2
vascular disease 1.2
sepsis 1.2
acute myeloid leukemia 1.2
hepatocellular carcinoma 1.2
gastric cancer 1.1
cognitive impairment 1.1
chronic disease 1.1
glioblastoma 1.1
GSH 1.1
colitis 1.0
tumor growth 1.0
sepsis 1.0
primary tumor 1.0
type 1 diabetes 0.9
cardiomyopathy 0.9
cirrhosis 0.9
adenoma 0.9
Crohn's disease 0.9
confusion 0.9
glaucoma 0.8
melanoma 0.8
inflammatory bowel disease 0.8
leukemia 0.8
SEM 0.8
immunodeficiency 0.7
dehydration 0.7
proteinuria 0.7
heart failure 0.7
metastases 0.6
plaque 0.6
suicide 0.5
ovarian cancer 0.5
cytomegalovirus 0.5
colon cancer 0.5
hyperglycemia 0.4
schizophrenia 0.4
hepatitis 0.4
Hodgkin's disease 0.4
myocardial ischemia 0.3
cardiovascular disease 0.3
hepatitis C 0.2
Infection 0.1
hepatitis B 0.1
malaria -0.2
cold -0.2
Mycobacterium -0.4
obesity -0.6
epilepsy -0.7
myocardial infarction -0.7
arthritis -0.8
tuberculosis -0.9
infectious diseases -1.1
depression -1.1
diabetes -1.8
stroke -1.9
HIV -2.1
Symptom
ataxic gait 6.2
ataxia 3.6
starvation 3.5
cerebellar ataxia 3.5
hypotonia 2.8
dystonia 2.2
seizures 2.2
tremor 2.1
functional recovery 1.6
collapse 1.5
acidity 1.4
weakness 1.1
overweight 0.6
Drug
Parkin 9.8
Parkin 9.8
Jujube 9.1
Pirarubicin 8.8
Bortezomib 6.7
TAK 6.3
Dasatinib 6.0
GEO 5.7
CIA 5.7
AMC 5.1
CoCl2 5.0
CoCl2 5.0
Arsenic trioxide 5.0
Ginseng 4.6
lysine 4.5
CPT-11 4.4
uPA 4.2
Alanine 3.8
Heme 3.7
Taxol 3.6
Retinoic acid 3.6
Kenyan 3.5
Glutathione 2.9
ICI 2.9
nitroglycerin 2.2
caffeine 0.9
NADH 0.9
IL-2 0.4
CSF 0.4
Dermatol -2.7
Enzyme
ubiquitin-protein ligase 15.3
ubiquityl-calmodulin synthetase 13.9
5,10-methenyltetrahydrofolate synthetase 10.8
3-hydroxybutyryl-CoA dehydrogenase 9.6
aminopeptidase I 9.4
arginyl-tRNA synthetase 9.2
galactinol synthase 8.8
isopeptidase 8.7
3C protease 8.3
proteasome 8.0
type 1 protein phosphatase 7.9
S-adenosyl-L-homocysteine hydrolase 7.2
separase 6.9
m-calpain 6.6
IscS 6.5
trehalase 6.5
chorismate mutase 6.5
diacylglycerol kinase 6.3
p80 6.2
cysteine synthase 6.0
3-hydroxyacyl-CoA dehydrogenase 5.9
fatty acid desaturase 5.8
E-2 5.8
glycerol kinase 5.8
leucine aminopeptidase 5.6
TSP-1 5.6
APC 5.5
cystathionine beta-synthase 5.4
IKK 5.3
ECH 5.2
NADH dehydrogenase 5.2
3-hydroxy-3-methylglutaryl-CoA reductase 5.2
alpha-ketoglutarate dehydrogenase 5.0
transketolase 4.9
DNA ligase 4.9
DNA ligase 4.9
TOR 4.8
farnesyltransferase 4.7
protein phosphatase 2A 4.7
PNGase F 4.7
polo-like kinase 1 4.7
granzyme B 4.6
cdc2 4.6
enolase 4.4
glutaminase 4.4
cathepsin L 4.3
chaperonin 4.2
complex I 4.2
thioredoxin reductase 4.0
hexokinase 3.9
lysozyme 3.9
RNA polymerase 3.9
MDP 3.9
histone acetyltransferase 3.9
phosphoinositide 3-kinase 3.8
diaphorase 3.8
isocitrate dehydrogenase 3.7
protein kinase 3.7
transcriptase 3.7
ornithine decarboxylase 3.6
furin 3.6
ricin 3.6
glutathione S-transferase 3.6
beta-glucosidase 3.6
ribonuclease 3.6
ribonuclease 3.6
isocitrate dehydrogenase 3.5
aldolase 3.5
arginase 3.4
CaMKII 3.3
proteinase K 3.3
cathepsin D 3.3
heme oxygenase 3.2
MMP 3.2
calcineurin 3.2
RNase 3.1
PARP 3.1
topoisomerase 3.0
DNA methyltransferase 3.0
caspase-3 3.0
ATPase 2.9
luciferase 2.9
NQO1 2.7
caspase-1 2.7
ERK 2.5
caspase-8 2.5
prostate-specific antigen 2.5
ATP synthase 2.5
beta-galactosidase 2.4
carbonic anhydrase 2.4
caspase-9 2.4
DNase 2.4
beta-glucuronidase 2.4
glucose-6-phosphate dehydrogenase 2.4
RNase 2.3
lipoxygenase 2.2
cytochrome oxidase 2.2
topoisomerase 2.1
phospholipase C 2.1
alcohol dehydrogenase 2.1
mitogen-activated protein kinase 2.1
CD10 2.0
chymotrypsin 1.9
protein kinase C 1.7
AMPK 1.7
acid phosphatase 1.6
AMP-activated protein kinase 1.6
trypsin 1.5
phospholipase A2 1.5
focal adhesion kinase 1.4
NO synthase 1.3
reverse transcriptase 1.3
DNA polymerase 1.2
endonuclease 1.1
lipase 1.1
phosphodiesterase 1.1
superoxide dismutase 1.0
lactate dehydrogenase 0.4
renin 0.2
ACS -1.0
Compound
Methyl caffeate 12.1
3-fluoropyridine 10.6
RUB 10.3
1,4-cyclohexanedione 9.7
Ubiquitin 9.3
Perillyl alcohol 9.2
Perillyl alcohol 9.2
Vinclozolin 9.1
PYR 8.8
Cbl 8.6
Embelin 8.4
Arabinogalactan 7.7
DGE 7.6
DGE 7.6
DGE 7.6
G 1 7.3
SSH 7.2
PPi 6.6
AICAR 6.6
CHIP 6.6
5-Azacytidine 6.5
DBT 6.4
Cortisone 6.4
AAA 6.3
AF-2 6.2
APH 6.1
DMPP 6.1
Glycogen synthase 6.1
Isoform 6.0
Arsenite 6.0
methanethiol 5.8
Uracil 5.7
AICAR 5.7
DEP 5.7
3-methylhistidine 5.7
Cycloheximide 5.6
MAD 5.6
Brefeldin A 5.6
Brefeldin A 5.6
adenylate 5.5
malononitrile 5.4
E-64 5.4
DEP 5.3
Artemisinin 5.3
SN-38 5.2
POP 5.0
isopentenyl diphosphate 4.9
40S 4.8
Guanine 4.8
lysine 4.7
CCP 4.6
Methamphetamine 4.6
Casein 4.5
myricetin 4.5
aldosterone 4.5
C2H2 4.5
CPT-11 4.4
ATF 4.4
DTT 4.3
DTT 4.2
DOC 4.2
BCNU 4.1
Vasopressin 4.1
Leucine 4.1
DPP 4.0
IAA 4.0
Arachidonic acid 4.0
DSS 4.0
ATP 4.0
Alanine 3.9
TNM 3.9
MMC 3.9
retinoic acid 3.9
IAA 3.8
GSSG 3.8
cysteine 3.8
pyrimidine 3.8
nicotinic acid 3.7
nicotinic acid 3.7
nicotinic acid 3.7
Quercetin 3.6
Rapamycin 3.6
succinic acid 3.5
Heme 3.5
PDB 3.4
DEAE 3.4
Ile 3.3
aniline 3.3
Gly 3.2
nicotinic acid 3.2
threonine 3.2
ABA 3.2
EMS 3.2
L-DOPA 3.1
serine 3.1
GAL 3.1
aldehyde 3.1
molybdenum 3.1
NAD 3.0
leucine 3.0
isoleucine 3.0
isoleucine 2.9
MPTP 2.9
AMP 2.9
hydroxylamine 2.9
HCO 2.9
arginine 2.9
ABA 2.9
methionine 2.9
APAP 2.9
pyrrolidine 2.9
cyanide 2.8
hydrazine 2.8
Cortisol 2.8
zinc 2.8
hydroxylamine 2.8
pyrrolidine 2.8
tyrosine 2.8
FK506 2.8
butyric acid 2.8
NH2 2.8
ubiquinone 2.7
aldehyde 2.7
butyric acid 2.7
COS 2.7
ICI 2.6
NAD 2.6
Melatonin 2.6
butyric acid 2.5
alanine 2.5
salt 2.5
quinoline 2.5
quinoline 2.5
benzoic acid 2.4
proline 2.3
MDA 2.3
Phytol 2.3
Phytol 2.3
adenosylmethionine 2.2
alcohol dehydrogenase 2.2
Phe 2.2
Asp 2.2
Dopamine 2.2
Collagen 2.1
GTP 2.0
His 2.0
Cholesterol 2.0
retinol 2.0
H2O2 2.0
THP 1.9
THP 1.9
sodium 1.9
salicylic acid 1.8
GDP 1.8
cAMP 1.8
DNA 1.8
uridine 1.6
SDS 1.6
ethyl acetate 1.5
GSH 1.5
GSH 1.5
Mg2+ 1.5
valine 1.4
hexane 1.4
ammonium 1.3
glutamic acid 1.3
cadmium 1.2
tryptophan 1.2
tryptophan 1.2
nitrogen 1.2
tryptophan 1.1
boron 1.1
sulfate 1.1
nitric oxide 1.0
TOF 1.0
tryptophan 0.9
urea 0.9
bromide 0.9
caffeine 0.9
NADH 0.9
glutamate 0.7
NADPH 0.7
NADPH 0.7
glutamine 0.6
calcium 0.5
silver 0.4
titanium 0.4
TNF 0.4
nickel 0.4
5-HT 0.3
MTT 0.3
glucose 0.3
Pac 0.2
GABA 0.2
manganese 0.2
GABA 0.2
galactose 0.1
Dec 0.0
glycerol -0.0
iron -0.2
phosphorus -0.2
iodine -0.3
creatinine -0.6
methanol -0.6
ethanol -0.8
ACS -1.0
ACS -1.0
water -1.1
hydrogen -1.4
Cardiol -1.6
oxygen -1.6
phosphate -2.1
BMC -2.2
Clin -2.5