Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.2.19 (ubiquitin-protein ligase)
 799 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ubiquitin-protein ligase 547
ubiquitin 433
proteasome 186
Mol 93
ubiquitin-conjugating enzyme 63
Sep 59
p53 59
Ubiquitin 55
ATP 52
ubiquitin ligase 51
Parkin 43
parkin 36
Nedd4-2 28
endoplasmic reticulum 27
E6-AP 25
SCF 24
ENaC 24
proteasome inhibitor 23
cyclin 22
RSP5 22
E3 ubiquitin ligase 21
UBE3A 20
UBC4 18
E2 ubiquitin-conjugating enzyme 18
E6AP 18
tRNA 16
APC 16
Skp1 13
ATPase 12
E6 protein 12
PINK1 11
HERC1 11
UbcH7 11
F-box protein 11
polypeptide 11
cytokine 11
alpha-synuclein 11
interacting protein 10
collecting duct 10
ubiquitin carrier protein 10
UBA1 10
RING-H2 10
RNA polymerase II 10
NMR 10
Mdm2 9
interferon 9
lysozyme 8
novel gene 8
histone 8
UBE1 8
ubiquitin-like protein 8
proline-rich 8
cullin 8
septin 8
sodium channel 8
PTEN 8
PARK2 8
caspase-3 7
UBE1L 7
epidermal growth factor receptor 7
AMP 7
p27 7
MDM2 7
histone H2B 7
UBA6 7
membrane protein 7
calmodulin 7
AAA 6
Itch 6
Proteasome 6
NEDD8 6
all-trans 6
PARKIN 6
transcriptional activator 6
Cyclin 6
tumor necrosis factor 6
anaphase-promoting complex/cyclosome 6
cyclin-dependent kinase 6
Met 6
securin 6
RING finger protein 6
calpain 6
tyrosine kinase 5
E2-F1 5
finger protein 5
FAT10 5
SFT 5
unknown function 5
Ubiquitin-protein ligase 5
amino acid permease 5
Ankyrin 5
nuclear protein 5
histone H3 5
estrogen receptor 5
UBR1 5
atrogin-1 5
p62 5
serine/threonine kinase 5
alpha, beta 5
UbcH8 5
interleukin-6 5
GTPase 5
phosphatase 5
H2A 5
WWP2 5
14-3-3 5
cage 5
zinc finger 5
Skp2 5
PDB 4
proliferating cell nuclear antigen 4
GST 4
ubiquitin-activating enzyme E1 4
p38 4
UFD2 4
CBL 4
NEDD4 4
small GTPase 4
ERK 4
IkappaBalpha 4
deubiquitinating enzyme 4
Rho 4
CDC20 4
adaptor protein 4
inhibitor of apoptosis 4
ubiquitin-specific protease 4
protein phosphatase 4
NAD 4
SKP2 4
UBC9 4
synphilin-1 4
XIAP 4
promyelocytic leukemia 4
cyclin D1 4
SDS 4
membrane-bound 4
ALA 4
threonine 4
HACE1 4
p27Kip1 4
UBP43 4
spermatozoa 4
E1B 4
cytochrome c 4
IkappaB kinase 4
vimentin 4
histone H2A 4
H2B 4
CCNF 3
transcriptional regulator 3
ARF 3
cyclin-dependent kinase inhibitor 3
HUWE1 3
p73 3
CCR4-NOT 3
catenin 3
chloride channel 3
ISG15 3
CHIP 3
glutathione S-transferase 3
p97 3
SKP1 3
olfactory 3
p65 3
LPS 3
Hdm2 3
receptor tyrosine kinase 3
IFN 3
hormone receptor 3
proto-oncogene 3
FBXO6 3
CDC16 3
Mule 3
nuclear receptor 3
HEK 3
cyclin F 3
superoxide dismutase 3
p21 3
LC3 3
erythroid 3
gamma-tubulin 3
HSP70 3
albumin 3
c-Jun 3
COP9 3
UBC 3
TLR4 3
prion 3
progesterone receptor 3
ARI 3
cytochrome P450 3
Ubc13 3
H2AX 3
hepatocyte growth factor 3
gene 4 3
telomeric 3
E3 protein 3
tumor suppressor protein 3
TNM 3
vasopressin 3
dimeric 3
cIAP2 3
glycoprotein 3
Cdc48 3
SOD 3
diubiquitin 3
Bcl-2 3
chimeric protein 3
insulin 3
Fas 3
USP18 3
APC11 3
lipopolysaccharide 3
tumour suppressor 3
GTP 3
erythropoietin 3
cyclin B1 3
EF-Tu 2
UCH-L1 2
beta-catenin 2
dystrophin 2
methyltransferase 2
PARP 2
MYC 2
SOD1 2
D. melanogaster 2
glial fibrillary acidic protein 2
pVHL 2
NEDD4L 2
myosin 2
STAT 2
DIAP1 2
NLRP2 2
vascular endothelial growth factor 2
MMS2 2
ubiquitin C 2
eukaryotic translation initiation factor 2
UBA3 2
SUMO2 2
MAPK 2
mineralocorticoid receptor 2
heat shock protein 90 2
JNK 2
ERK1 2
X-linked inhibitor of apoptosis protein 2
c-fms 2
MMP-9 2
enolase 2
ankyrin 2
p14 2
UBR5 2
c-myc 2
ubiquitin-conjugating enzyme E2 2
pRb 2
adapter protein 2
peroxisome proliferator-activated receptor 2
UCHL1 2
RNF186 2
TRIM32 2
ClC-5 2
NADH dehydrogenase 2
RNase A 2
peptidase 2
JAK2 2
trehalase 2
pol 2
CUL1 2
AGP1 2
AKT 2
MyD88 2
syntaxin 2
GABA(A) receptor 2
dynamin 2
core protein 2
synuclein 2
arginyl-tRNA synthetase 2
Praja-1 2
dynamin-related protein 1 2
extracellular signal regulated kinase 2
CK2 2
SMAD4 2
UBE2D1 2
HDM2 2
adenomatous polyposis coli 2
Doc1 2
gp78 2
scribble 2
E2 protein 2
TLR9 2
Pop1 2
TRIM 2
VCP 2
ATG7 2
RNF40 2
Rbx1 2
DJ-1 2
GTPase-activating protein 2
SUMO 2
ribosomal protein L11 2
LRRK2 2
AP-2 2
SC35 2
sugar transporter 2
cbl-b 2
p45 2
endoprotease 2
amyloid precursor protein 2
53BP1 2
ARIH1 2
RING-IBR 2
potential tumor suppressor 2
Yes 2
TSG101 2
PML 2
MAP1LC3B 2
arginyl-tRNA-protein transferase 2
UbcH6 2
hedgehog 2
SMAD3 2
casein 2
more...
Disease
cancer 82
tumor 55
Parkinson's disease 46
parkinsonism 29
tumorigenesis 21
Angelman syndrome 20
APC 16
breast cancer 16
hypertension 14
Liddle's syndrome 14
lung cancer 12
carcinogenesis 10
carcinoma 9
multiple myeloma 9
amyotrophic lateral sclerosis 9
dementia 8
Alzheimer's disease 8
PARK2 8
pruritus 7
lymphoma 7
adenocarcinoma 7
cervical cancer 7
abdominal aortic aneurysm 6
AAA 6
MCF 5
tumor progression 5
non-small cell lung cancer 5
mental retardation 5
autism 5
acute promyelocytic leukemia 5
mental retardation 5
Huntington's disease 5
colorectal cancer 5
muscular atrophy 5
Hippel 4
prostate cancer 4
leukemia 4
hepatocellular carcinoma 4
metastases 4
virus infection 4
neuroblastoma 4
squamous cell carcinoma 4
SDS 4
lung carcinoma 4
pancreatic cancer 3
immunodeficiency 3
melanoma 3
sepsis 3
heart failure 3
retinoblastoma 3
developmental delay 3
respiratory failure 3
ARF 3
IBR 3
Blocking 3
tumor growth 3
papilloma 3
sepsis 3
Heller 2
schizophrenia 2
cystic fibrosis 2
aggressiveness 2
metastatic melanoma 2
Japanese encephalitis 2
depression 2
cirrhosis 2
obsessive-compulsive disorder 2
Epstein 2
dysplasia 2
Kaposi's sarcoma 2
diabetes 2
gastric cancer 2
cognitive impairment 2
PML 2
Still 2
SEM 2
skin cancer 2
chronic lymphocytic leukemia 2
vaccinia 2
oral cancer 2
synovial sarcoma 2
hepatitis A 2
genetic disorder 2
ulcerative colitis 2
erythroleukemia 2
cold 2
chronic lymphocytic leukemia 2
herpes simplex 2
neurological disease 2
GSH 2
plaque 2
obesity 2
mantle cell lymphoma 2
acute myeloid leukemia 2
cardiovascular disease 2
LAP 2
glioma 2
OPA1 1
RP4 1
sleep disturbances 1
liver fibrosis 1
Rett syndrome 1
neoplastic transformation 1
IVF 1
vascular disease 1
Dementia with Lewy bodies 1
NPHP3 1
NLS 1
suicide 1
Autism 1
mammary tumor 1
adenoma 1
Machado-Joseph disease 1
Autism spectrum disorder 1
macular degeneration 1
dermatitis 1
molluscum contagiosum 1
PDB 1
chancroid 1
NS3 1
SMAX2 1
myocardial ischemia 1
proteinuria 1
Pancreas 1
Melanoma 1
ICD 1
stroke 1
cardiomyopathy 1
embryonal carcinoma 1
type 1 diabetes 1
subarachnoid hemorrhage 1
Cushing's syndrome 1
anal atresia 1
xeroderma pigmentosum 1
worms 1
coxsackievirus 1
hyperglycemia 1
severe mental retardation 1
Mycobacterium 1
choriocarcinoma 1
Azul 1
limb-girdle muscular dystrophy 1
pituitary adenoma 1
language disorder 1
chronic disease 1
malaria 1
Staring 1
Schistosoma mansoni 1
Canavan 1
myocardial infarction 1
myocarditis 1
WT1 1
carcinoma in situ 1
Dent's disease 1
arthritis 1
uremia 1
brachycephaly 1
HCG 1
XPB 1
HIV 1
muscular dystrophy 1
hepatic encephalopathy 1
epithelial ovarian cancer 1
primary tumor 1
PARK6 1
hepatitis 1
FBS 1
cutaneous melanoma 1
dehydration 1
hepatitis B 1
ovarian cancer 1
EBM 1
PHP 1
uterine cancer 1
Hodgkin's disease 1
hepatitis C 1
basal cell carcinoma 1
telangiectasia 1
cytomegalovirus 1
colitis 1
MAS 1
tuberculosis 1
PARK1 1
epilepsy 1
HGF 1
Legionella 1
adult brain tumor 1
DSS 1
ATM 1
CEM 1
RDA 1
Infection 1
CYLD 1
plant disease 1
Cockayne syndrome 1
DSS 1
mimicry 1
Anisakis 1
gastrointestinal stromal tumor 1
periodontal disease 1
motor neuron disease 1
RP11 1
Brown 1
scrotum 1
lymphoblastic leukemia 1
colon cancer 1
dyslipidemia 1
periodontitis 1
Spinocerebellar ataxia 1
stromal tumors 1
infectious diseases 1
Cholangiocarcinoma 1
SCID 1
azoospermia 1
Juvenile Parkinsonism 1
riboflavin deficiency 1
male infertility 1
pancreatitis 1
Pancreas 1
confusion 1
CRV 1
dilated cardiomyopathy 1
renal cancer 1
bipolar disorder 1
inflammatory bowel disease 1
achalasia 1
esophageal atresia 1
viral diarrhea 1
Cholangiocarcinoma 1
metastatic breast cancer 1
glaucoma 1
Crohn's disease 1
renal hypertension 1
solid tumor 1
glioblastoma 1
adult T-cell leukemia/lymphoma 1
leukodystrophy 1
scoliosis 1
hematologic malignancies 1
glioblastoma multiforme 1
Symptom
seizures 9
starvation 7
ataxia 5
collapse 2
weakness 2
tremor 2
overweight 1
cerebellar ataxia 1
functional recovery 1
dystonia 1
ataxic gait 1
acidity 1
hypotonia 1
Drug
Parkin 43
Parkin 43
lysine 34
Bortezomib 4
TAK 2
GEO 2
uPA 1
Dermatol 1
Alanine 1
IL-2 1
Glutathione 1
CPT-11 1
CSF 1
Arsenic trioxide 1
caffeine 1
CIA 1
NADH 1
Dasatinib 1
Ginseng 1
Taxol 1
CoCl2 1
CoCl2 1
Jujube 1
Retinoic acid 1
Pirarubicin 1
ICI 1
AMC 1
nitroglycerin 1
Kenyan 1
Heme 1
Enzyme
ubiquitin-protein ligase 799
proteasome 188
protein kinase 26
APC 18
ERK 14
RNA polymerase 13
ATPase 12
mitogen-activated protein kinase 10
lysozyme 8
glutathione S-transferase 7
luciferase 7
caspase-3 7
isopeptidase 6
IKK 5
cdc2 5
protein kinase C 4
3C protease 4
calcineurin 4
RNase 4
complex I 4
transcriptase 3
superoxide dismutase 3
trypsin 3
PARP 3
focal adhesion kinase 3
ubiquityl-calmodulin synthetase 3
diaphorase 2
diacylglycerol kinase 2
enolase 2
beta-galactosidase 2
granzyme B 2
trehalase 2
protein phosphatase 2A 2
phospholipase C 2
DNA ligase 2
ornithine decarboxylase 2
phosphoinositide 3-kinase 2
aminopeptidase I 2
hexokinase 2
leucine aminopeptidase 2
reverse transcriptase 2
topoisomerase 2
ribonuclease 2
NADH dehydrogenase 2
RNase 2
DNA ligase 2
m-calpain 2
arginyl-tRNA synthetase 2
ribonuclease 2
carbonic anhydrase 1
AMP-activated protein kinase 1
transketolase 1
ACS 1
DNase 1
glucose-6-phosphate dehydrogenase 1
IscS 1
cystathionine beta-synthase 1
renin 1
heme oxygenase 1
E-2 1
cytochrome oxidase 1
chaperonin 1
chorismate mutase 1
cathepsin D 1
DNA polymerase 1
isocitrate dehydrogenase 1
beta-glucosidase 1
lipase 1
ECH 1
chymotrypsin 1
NQO1 1
proteinase K 1
ATP synthase 1
furin 1
endonuclease 1
NO synthase 1
prostate-specific antigen 1
isocitrate dehydrogenase 1
phosphodiesterase 1
type 1 protein phosphatase 1
TSP-1 1
CD10 1
acid phosphatase 1
phospholipase A2 1
galactinol synthase 1
MMP 1
3-hydroxy-3-methylglutaryl-CoA reductase 1
cysteine synthase 1
TOR 1
arginase 1
3-hydroxybutyryl-CoA dehydrogenase 1
ricin 1
caspase-8 1
beta-glucuronidase 1
separase 1
caspase-9 1
S-adenosyl-L-homocysteine hydrolase 1
5,10-methenyltetrahydrofolate synthetase 1
alpha-ketoglutarate dehydrogenase 1
topoisomerase 1
lactate dehydrogenase 1
AMPK 1
lipoxygenase 1
3-hydroxyacyl-CoA dehydrogenase 1
aldolase 1
p80 1
cathepsin L 1
farnesyltransferase 1
MDP 1
CaMKII 1
glycerol kinase 1
PNGase F 1
polo-like kinase 1 1
alcohol dehydrogenase 1
glutaminase 1
DNA methyltransferase 1
caspase-1 1
fatty acid desaturase 1
histone acetyltransferase 1
thioredoxin reductase 1
Compound
DNA 71
Dec 54
lysine 53
ATP 52
Ubiquitin 43
cysteine 26
sodium 26
Cbl 18
arginine 18
tyrosine 17
salt 16
zinc 16
serine 14
aldosterone 14
calcium 12
leucine 12
methionine 11
alanine 10
threonine 10
retinoic acid 9
glucose 9
nitrogen 9
water 8
His 8
NH2 8
AMP 8
Gly 8
pyrimidine 7
Clin 7
PYR 7
adenylate 7
AAA 6
Phe 6
sulfate 6
Ile 5
nitric oxide 5
PPi 5
cAMP 5
NAD 4
NAD 4
aldehyde 4
SDS 4
aldehyde 4
proline 4
Asp 4
ammonium 4
DEAE 4
RUB 3
glutamate 3
iron 3
GSH 3
H2O2 3
GTP 3
cyanide 3
urea 3
oxygen 3
Cycloheximide 3
GSH 3
TNM 3
MDA 3
hydrogen 2
cadmium 2
AICAR 2
tryptophan 2
L-DOPA 2
tryptophan 2
Mg2+ 2
bromide 2
isoleucine 2
tryptophan 2
Glycogen synthase 2
molybdenum 2
galactose 2
Cardiol 2
GSSG 2
40S 2
TNF 2
ethanol 2
silver 2
aniline 2
CHIP 2
AICAR 2
COS 2
isoleucine 2
tryptophan 2
IAA 1
boron 1
Vinclozolin 1
butyric acid 1
Arsenite 1
Methamphetamine 1
GDP 1
ubiquinone 1
MAD 1
HCO 1
hydrazine 1
Cortisone 1
phosphorus 1
phosphate 1
alcohol dehydrogenase 1
hexane 1
BMC 1
butyric acid 1
DGE 1
Melatonin 1
NADPH 1
Rapamycin 1
nicotinic acid 1
quinoline 1
methanethiol 1
Methyl caffeate 1
Guanine 1
MPTP 1
Casein 1
ethyl acetate 1
Vasopressin 1
ACS 1
manganese 1
salicylic acid 1
Cholesterol 1
DSS 1
titanium 1
succinic acid 1
Phytol 1
ATF 1
TOF 1
valine 1
Arachidonic acid 1
3-methylhistidine 1
nicotinic acid 1
Brefeldin A 1
DBT 1
CPT-11 1
PDB 1
Perillyl alcohol 1
Phytol 1
uridine 1
FK506 1
Quercetin 1
Collagen 1
Heme 1
DGE 1
NADH 1
DEP 1
Dopamine 1
hydroxylamine 1
5-Azacytidine 1
GABA 1
GABA 1
Perillyl alcohol 1
myricetin 1
Arabinogalactan 1
3-fluoropyridine 1
Isoform 1
E-64 1
MMC 1
Artemisinin 1
NADPH 1
DEP 1
ABA 1
DPP 1
GAL 1
1,4-cyclohexanedione 1
ICI 1
pyrrolidine 1
retinol 1
EMS 1
adenosylmethionine 1
iodine 1
pyrrolidine 1
Cortisol 1
THP 1
glycerol 1
benzoic acid 1
SSH 1
nicotinic acid 1
malononitrile 1
5-HT 1
Brefeldin A 1
ABA 1
nickel 1
APH 1
DGE 1
creatinine 1
C2H2 1
Uracil 1
CCP 1
isopentenyl diphosphate 1
DMPP 1
ACS 1
AF-2 1
methanol 1
THP 1
BCNU 1
DTT 1
glutamine 1
quinoline 1
MTT 1
butyric acid 1
glutamic acid 1
Embelin 1
Pac 1
hydroxylamine 1
DTT 1
SN-38 1
APAP 1
G 1 1
IAA 1
nicotinic acid 1
Alanine 1
caffeine 1
DOC 1
Leucine 1
POP 1