Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.3.2.19 (ubiquitin-protein ligase)
 799 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ubiquitin-protein ligase 547
ubiquitin 433
proteasome 186
Mol 93
ubiquitin-conjugating enzyme 63
Sep 59
p53 59
Ubiquitin 55
ATP 52
ubiquitin ligase 51
Parkin 43
parkin 36
Nedd4-2 28
endoplasmic reticulum 27
E6-AP 25
SCF 24
ENaC 24
proteasome inhibitor 23
cyclin 22
RSP5 22
E3 ubiquitin ligase 21
UBE3A 20
E2 ubiquitin-conjugating enzyme 18
E6AP 18
UBC4 18
APC 16
tRNA 16
Skp1 13
E6 protein 12
ATPase 12
F-box protein 11
PINK1 11
polypeptide 11
HERC1 11
UbcH7 11
cytokine 11
alpha-synuclein 11
collecting duct 10
ubiquitin carrier protein 10
RING-H2 10
interacting protein 10
NMR 10
UBA1 10
RNA polymerase II 10
Mdm2 9
interferon 9
sodium channel 8
proline-rich 8
novel gene 8
ubiquitin-like protein 8
cullin 8
lysozyme 8
PTEN 8
histone 8
septin 8
UBE1 8
PARK2 8
AMP 7
epidermal growth factor receptor 7
p27 7
UBA6 7
MDM2 7
calmodulin 7
membrane protein 7
UBE1L 7
histone H2B 7
caspase-3 7
Met 6
cyclin-dependent kinase 6
anaphase-promoting complex/cyclosome 6
PARKIN 6
securin 6
Cyclin 6
RING finger protein 6
NEDD8 6
all-trans 6
AAA 6
transcriptional activator 6
Itch 6
calpain 6
tumor necrosis factor 6
Proteasome 6
UBR1 5
tyrosine kinase 5
UbcH8 5
amino acid permease 5
phosphatase 5
p62 5
GTPase 5
interleukin-6 5
atrogin-1 5
nuclear protein 5
alpha, beta 5
cage 5
E2-F1 5
histone H3 5
Skp2 5
FAT10 5
Ubiquitin-protein ligase 5
Ankyrin 5
estrogen receptor 5
H2A 5
unknown function 5
WWP2 5
serine/threonine kinase 5
SFT 5
zinc finger 5
finger protein 5
14-3-3 5
ERK 4
threonine 4
cytochrome c 4
vimentin 4
Rho 4
GST 4
ALA 4
cyclin D1 4
ubiquitin-activating enzyme E1 4
HACE1 4
histone H2A 4
UBP43 4
p27Kip1 4
spermatozoa 4
small GTPase 4
SDS 4
E1B 4
proliferating cell nuclear antigen 4
IkappaB kinase 4
CBL 4
H2B 4
UBC9 4
inhibitor of apoptosis 4
NAD 4
membrane-bound 4
adaptor protein 4
p38 4
synphilin-1 4
CDC20 4
UFD2 4
protein phosphatase 4
SKP2 4
PDB 4
promyelocytic leukemia 4
XIAP 4
NEDD4 4
IkappaBalpha 4
ubiquitin-specific protease 4
deubiquitinating enzyme 4
Ubc13 3
Hdm2 3
receptor tyrosine kinase 3
CHIP 3
superoxide dismutase 3
telomeric 3
p65 3
ARF 3
E3 protein 3
transcriptional regulator 3
IFN 3
cyclin-dependent kinase inhibitor 3
more...
Disease
cancer 82
tumor 55
Parkinson's disease 46
parkinsonism 29
tumorigenesis 21
Angelman syndrome 20
breast cancer 16
APC 16
hypertension 14
Liddle's syndrome 14
lung cancer 12
carcinogenesis 10
amyotrophic lateral sclerosis 9
multiple myeloma 9
carcinoma 9
Alzheimer's disease 8
dementia 8
PARK2 8
lymphoma 7
adenocarcinoma 7
cervical cancer 7
pruritus 7
AAA 6
abdominal aortic aneurysm 6
colorectal cancer 5
mental retardation 5
autism 5
muscular atrophy 5
MCF 5
non-small cell lung cancer 5
tumor progression 5
Huntington's disease 5
acute promyelocytic leukemia 5
mental retardation 5
neuroblastoma 4
squamous cell carcinoma 4
hepatocellular carcinoma 4
virus infection 4
lung carcinoma 4
SDS 4
prostate cancer 4
metastases 4
leukemia 4
Hippel 4
papilloma 3
melanoma 3
ARF 3
sepsis 3
immunodeficiency 3
Blocking 3
pancreatic cancer 3
retinoblastoma 3
sepsis 3
IBR 3
tumor growth 3
respiratory failure 3
heart failure 3
developmental delay 3
cold 2
genetic disorder 2
Epstein 2
Heller 2
cystic fibrosis 2
aggressiveness 2
diabetes 2
schizophrenia 2
obesity 2
gastric cancer 2
PML 2
depression 2
obsessive-compulsive disorder 2
metastatic melanoma 2
cirrhosis 2
SEM 2
Kaposi's sarcoma 2
skin cancer 2
oral cancer 2
herpes simplex 2
acute myeloid leukemia 2
vaccinia 2
erythroleukemia 2
mantle cell lymphoma 2
chronic lymphocytic leukemia 2
chronic lymphocytic leukemia 2
hepatitis A 2
Still 2
synovial sarcoma 2
neurological disease 2
cardiovascular disease 2
cognitive impairment 2
Japanese encephalitis 2
GSH 2
dysplasia 2
ulcerative colitis 2
plaque 2
LAP 2
glioma 2
OPA1 1
RP4 1
sleep disturbances 1
liver fibrosis 1
Rett syndrome 1
neoplastic transformation 1
IVF 1
vascular disease 1
Dementia with Lewy bodies 1
NPHP3 1
NLS 1
suicide 1
Autism 1
mammary tumor 1
adenoma 1
Machado-Joseph disease 1
Autism spectrum disorder 1
macular degeneration 1
dermatitis 1
molluscum contagiosum 1
PDB 1
chancroid 1
NS3 1
SMAX2 1
myocardial ischemia 1
proteinuria 1
Pancreas 1
Melanoma 1
HCG 1
ICD 1
HIV 1
embryonal carcinoma 1
type 1 diabetes 1
PARK6 1
coxsackievirus 1
hyperglycemia 1
severe mental retardation 1
Cushing's syndrome 1
ovarian cancer 1
PHP 1
Azul 1
Hodgkin's disease 1
pituitary adenoma 1
HGF 1
WT1 1
cytomegalovirus 1
carcinoma in situ 1
uremia 1
malaria 1
Staring 1
Schistosoma mansoni 1
Canavan 1
DSS 1
adult brain tumor 1
cutaneous melanoma 1
dehydration 1
plant disease 1
DSS 1
basal cell carcinoma 1
Anisakis 1
gastrointestinal stromal tumor 1
MAS 1
tuberculosis 1
more...
Symptom
seizures 9
starvation 7
ataxia 5
collapse 2
weakness 2
tremor 2
overweight 1
cerebellar ataxia 1
functional recovery 1
dystonia 1
ataxic gait 1
acidity 1
hypotonia 1
Drug
Parkin 43
Parkin 43
lysine 34
Bortezomib 4
TAK 2
GEO 2
uPA 1
Dermatol 1
Alanine 1
IL-2 1
Glutathione 1
CPT-11 1
CSF 1
Arsenic trioxide 1
caffeine 1
CIA 1
NADH 1
Dasatinib 1
Ginseng 1
Taxol 1
CoCl2 1
CoCl2 1
Jujube 1
Retinoic acid 1
Pirarubicin 1
ICI 1
AMC 1
nitroglycerin 1
Kenyan 1
Heme 1
Enzyme
ubiquitin-protein ligase 799
proteasome 188
protein kinase 26
APC 18
ERK 14
RNA polymerase 13
ATPase 12
mitogen-activated protein kinase 10
lysozyme 8
glutathione S-transferase 7
luciferase 7
caspase-3 7
isopeptidase 6
IKK 5
cdc2 5
protein kinase C 4
3C protease 4
calcineurin 4
RNase 4
complex I 4
transcriptase 3
superoxide dismutase 3
trypsin 3
PARP 3
focal adhesion kinase 3
ubiquityl-calmodulin synthetase 3
diaphorase 2
diacylglycerol kinase 2
enolase 2
beta-galactosidase 2
granzyme B 2
trehalase 2
protein phosphatase 2A 2
phospholipase C 2
DNA ligase 2
ornithine decarboxylase 2
phosphoinositide 3-kinase 2
aminopeptidase I 2
hexokinase 2
leucine aminopeptidase 2
reverse transcriptase 2
topoisomerase 2
ribonuclease 2
NADH dehydrogenase 2
RNase 2
DNA ligase 2
m-calpain 2
arginyl-tRNA synthetase 2
ribonuclease 2
carbonic anhydrase 1
AMP-activated protein kinase 1
transketolase 1
ACS 1
DNase 1
glucose-6-phosphate dehydrogenase 1
IscS 1
cystathionine beta-synthase 1
renin 1
heme oxygenase 1
E-2 1
cytochrome oxidase 1
chaperonin 1
chorismate mutase 1
cathepsin D 1
DNA polymerase 1
isocitrate dehydrogenase 1
beta-glucosidase 1
lipase 1
ECH 1
chymotrypsin 1
NQO1 1
proteinase K 1
ATP synthase 1
furin 1
endonuclease 1
NO synthase 1
prostate-specific antigen 1
isocitrate dehydrogenase 1
phosphodiesterase 1
type 1 protein phosphatase 1
TSP-1 1
CD10 1
acid phosphatase 1
phospholipase A2 1
galactinol synthase 1
MMP 1
3-hydroxy-3-methylglutaryl-CoA reductase 1
cysteine synthase 1
TOR 1
arginase 1
3-hydroxybutyryl-CoA dehydrogenase 1
ricin 1
caspase-8 1
beta-glucuronidase 1
separase 1
caspase-9 1
S-adenosyl-L-homocysteine hydrolase 1
5,10-methenyltetrahydrofolate synthetase 1
alpha-ketoglutarate dehydrogenase 1
topoisomerase 1
lactate dehydrogenase 1
AMPK 1
lipoxygenase 1
3-hydroxyacyl-CoA dehydrogenase 1
aldolase 1
p80 1
cathepsin L 1
farnesyltransferase 1
MDP 1
CaMKII 1
glycerol kinase 1
PNGase F 1
polo-like kinase 1 1
alcohol dehydrogenase 1
glutaminase 1
DNA methyltransferase 1
caspase-1 1
fatty acid desaturase 1
histone acetyltransferase 1
thioredoxin reductase 1
Compound
DNA 71
Dec 54
lysine 53
ATP 52
Ubiquitin 43
cysteine 26
sodium 26
Cbl 18
arginine 18
tyrosine 17
zinc 16
salt 16
aldosterone 14
serine 14
leucine 12
calcium 12
methionine 11
alanine 10
threonine 10
nitrogen 9
retinoic acid 9
glucose 9
water 8
His 8
NH2 8
Gly 8
AMP 8
adenylate 7
Clin 7
pyrimidine 7
PYR 7
AAA 6
sulfate 6
Phe 6
PPi 5
cAMP 5
nitric oxide 5
Ile 5
SDS 4
proline 4
ammonium 4
aldehyde 4
aldehyde 4
NAD 4
Asp 4
NAD 4
DEAE 4
Cycloheximide 3
GSH 3
iron 3
H2O2 3
glutamate 3
GTP 3
cyanide 3
urea 3
TNM 3
GSH 3
oxygen 3
RUB 3
MDA 3
hydrogen 2
bromide 2
Glycogen synthase 2
AICAR 2
molybdenum 2
cadmium 2
GSSG 2
tryptophan 2
TNF 2
tryptophan 2
isoleucine 2
aniline 2
Cardiol 2
isoleucine 2
Mg2+ 2
galactose 2
ethanol 2
COS 2
silver 2
CHIP 2
AICAR 2
L-DOPA 2
tryptophan 2
40S 2
tryptophan 2
IAA 1
boron 1
Vinclozolin 1
butyric acid 1
Arsenite 1
Methamphetamine 1
GDP 1
ubiquinone 1
MAD 1
HCO 1
hydrazine 1
Cortisone 1
phosphorus 1
phosphate 1
alcohol dehydrogenase 1
hexane 1
BMC 1
butyric acid 1
DGE 1
Melatonin 1
NADPH 1
Rapamycin 1
nicotinic acid 1
quinoline 1
methanethiol 1
Methyl caffeate 1
Guanine 1
MPTP 1
MMC 1
E-64 1
Artemisinin 1
manganese 1
salicylic acid 1
1,4-cyclohexanedione 1
TOF 1
Brefeldin A 1
DBT 1
DSS 1
titanium 1
succinic acid 1
ATF 1
Cortisol 1
Arachidonic acid 1
FK506 1
Quercetin 1
3-methylhistidine 1
malononitrile 1
Dopamine 1
PDB 1
GABA 1
creatinine 1
GABA 1
Perillyl alcohol 1
myricetin 1
Arabinogalactan 1
Heme 1
DGE 1
NADH 1
ACS 1
ABA 1
DTT 1
EMS 1
Pac 1
glycerol 1
benzoic acid 1
Isoform 1
5-HT 1
ABA 1
G 1 1
nickel 1
APH 1
C2H2 1
Uracil 1
CCP 1
isopentenyl diphosphate 1
more...