Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.2.19 (
ubiquitin-protein ligase
)
799
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
RNF144A
is involved in protein ubiquitination and functions as an
ubiquitin-protein ligase
(E3) via its RING finger domain (
RNF144A
RING).
RNF144A
is associated with degradation of heat-shock protein family A member 2 (HSPA2), which leads to the suppression of breast cancer cell proliferation. In this study, the solution structure of
RNF144A
RING was determined using nuclear magnetic resonance. Moreover, using a metallochromic indicator, we spectrophotometrically determined the stoichiometry of zinc ions and elucidated that
RNF144A
RING binds two zinc atoms. This structural analysis provided the position and range of the active site of
RNF144A
RING at the atomic level, which contributes to the creation of artificial RING fingers having the specific ubiquitin-conjugating enzyme (E2)-binding capability.
...
PMID:Solution structure of the zinc finger domain of human RNF144A ubiquitin ligase. 3255 73
