Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.2.19 (
ubiquitin-protein ligase
)
799
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ring finger protein 1
(
RING1
) is a RING domain characterized protein belonging to the RING finger family. It is an E3
ubiquitin-protein ligase
that mediated monoubiquitination of histone H2A and the core component of PRC1 complex, which is the repressive multiprotein complex of Polycomb group (PcG). Previous studies showed the important tumorigenic role of
RING1
via promoting cell proliferation and the crucial function in maintaining transcriptional program stability during development. However, its mechanism for spinal cord injury (SCI) is still unknown. In our research, we established an acute SCI model in adult rats and studied the expression and function profiles of
RING1
.
RING1
protein level detected by western blot peaked at day 3 after trauma and then decreased gradually. Immunohistochemistry showed the increase of
RING1
expression displayed in the white matter more obviously than in the gray matter. Furthermore, increased co-expression of
RING1
and GFAP confirmed activated astrocytes in injured spinal cord via double immunofluorescence staining. Meanwhile, we also found the co-localization of PCNA, a famous marker of proliferative cells, with
RING1
and GFAP, which indicated
RING1
might play a role in astrocyte proliferation after SCI. In vitro studies,
RING1
protein level in C6 cells increased after LPS challenge and
RING1
was required for astrocyte proliferation and activation induced by LPS. In summary, we took a new insight into the function of
RING1
in the cellular and molecular mechanism underlying the pathophysiology of SCI.
...
PMID:Spatiotemporal Patterns of RING1 Expression after Rat Spinal Cord Injury. 2803 93
