Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.2.19 (
ubiquitin-protein ligase
)
799
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The Saccharomyces cerevisiae RPS0A/B genes encode proteins of the 40S ribosomal subunit that are required for the maturation of 18S rRNA. We show here that the RPS0 genes interact genetically with
TOM1
.
TOM1
encodes a member of the hect-domain-containing E3
ubiquitin-protein ligase
family that is required for growth at elevated temperatures. Mutant alleles of the RPS0 and
TOM1
genes have synergistic effects on cell growth at temperatures permissive for
TOM1
mutants. Moreover, the growth arrest of
TOM1
mutants at elevated temperatures is partially suppressed by overexpression of RPS0A/B. Strains with mutant alleles of
TOM1
are defective in multiple steps in rRNA processing, and interactions between RPS0A/B and
TOM1
stem, in part, from their roles in the maturation of ribosomal subunits. Ribosome synthesis is therefore included among the cellular processes governed by members of the hect-domain-containing E3
ubiquitin-protein ligase
family.
...
PMID:Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis. 1123 98
