Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.3.2.19 (
ubiquitin-protein ligase
)
799
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Deregulation of the
ubiquitin-protein ligase
E6AP contributes to the development of the Angelman syndrome and to cervical carcinogenesis suggesting that the activity of E6AP needs to be under tight control. However, how E6AP activity is regulated at the post-translational level under non-pathologic conditions is poorly understood. In this study, we report that the giant protein
HERC2
, which is like E6AP a member of the HECT family of ubiquitin-protein ligases, binds to E6AP. The interaction is mediated by the RCC1-like domain 2 of
HERC2
and a region spanning amino acid residues 150-200 of E6AP. Furthermore, we provide evidence that
HERC2
stimulates the
ubiquitin-protein ligase
activity of E6AP in vitro and within cells and that this stimulatory effect does not depend on the
ubiquitin-protein ligase
activity of
HERC2
. Thus, the data obtained indicate that
HERC2
acts as a regulator of E6AP.
...
PMID:Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2. 2149 13
