Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:6.2.1.7 (BAL)
 1,977 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 49 patients with pulmonary sarcoidosis BAL differential and T-cell count, determination of IgG, IgA levels in BAL-fluid were performed. A significant increase of lymphocytes, T-cell count and levels of IgG in BAL-fluid in patients with active sarcoidosis was found. Steroid therapy significantly lowered lymphocyte counts and increased the number of macrophages.
Pneumonol Pol 1990 Jan
PMID:[Cell count and immunoglobulin level in the bronchoalveolar lavage fluid (BALF) in patients with sarcoidosis]. 232 24

The results of a preliminary analysis on the role of lymphocyte count on prognosis of therapy outcome and influencing the decision to start therapy carried out on 21 patients with sarcoidosis are presented. The decision to commence treatment was carried out after BAL was performed but the results of it were not taken in account. The patients were observed for 7 to 33 months. The course of the disease was assessed basing on clinical, radiological and functional examination. In 6 patients a control BAL was carried out. The results allow to state that high lymphocyte BAL counts do not have to be poor prognostic factors. On the other hand low counts cannot predict a benign clinical course. In the discussion the authors evaluate, basing on literature data, the role of BAL in sarcoidosis.
Pneumonol Pol
PMID:[The role of BAL in the process of decision making with regard to the treatment of sarcoidosis]. 239 80

Diagnostic usefulness of BAL was assessed in 25 selected cases of interstitial lung diseases. There were 14 cases of allergic alveolitis, 6 cases of idiopathic pulmonary fibrosis and one case each of sarcoidosis, lymphangiomyomatosis, granulomotosis bronchocentrica, lymphogranulomatosis maligna, alveolitis of unknown etiology. BAL was assessed diagnostically usefull in 77% of the cases. More helpful was medical history which proved to be useful in all cases, and pulmonary function tests which were helpful in 84%. Lung biopsy was diagnostic in 66.6% of the cases, TBLB in 36.5%, while open lung biopsy carried out in 6 patients was diagnostic in 100%. Bronchoalveolar lavage is a useful element of diagnostic evaluation in patients with interstitial lung disorders, it is a safe method and well tolerated by the patients.
Pneumonol Pol 1989 Feb
PMID:[Preliminary evaluation of the diagnostic usefulness of bronchoalveolar lavage (BAL) in selected cases of interstitial lung diseases]. 258 2

Serum and BAL CEA levels were determined in stage I (WHO scale) lung cancer patients. The immuno-enzyme assay for the quantitative determination of CEA according to enzyme-linked immunosorbent assay (ELISA) principle was used. Eight smokers without symptoms of respiratory disease served as a control group. The CEA levels were also determined in 48 patients with chronic bronchitis to evaluate the influence the role of the inflammatory processes of the respiratory tract in producing CAE. All determined serum, and BAL fluid CEA levels were related to total protein and albumin for comparison of both media. It was shown that the BAL fluid CEA levels in lung cancer patients exceeded 10-fold the control levels, and twice fold the levels found in chronic bronchitis. It must be emphasized that serum levels were within normal limits in all analysed groups. The concentration of CEA expressed as ratio to total protein and albumin supported a diagnostic usefulness of CEA in BAL and indicated a slight modification of it by inflammatory process.
Pneumonol Pol 1989 May
PMID:[Concentration of carcinoembryonic antigen in the serum and bronchoalveolar lavage fluid in patients with lung cancer]. 263 45

27 rural inhabitants with allergic alveoltis were evaluated in order to determine the diagnostic usefulness of clinical, radiological, functional examination, BAL, lung biopsy, presence of serum antibodies against environmental antigens in determining the diagnosis and clinical stage of the disease. The effect of therapy and exposition on lung function tests were also discussed. Corticotherapy in most of the patients produced an improvement of vital capacity. In part of the patients isolation from environmental antigens produced stabilization of respiratory parameters. Small dose continuous corticotherapy in patients with prolonged exposition proved to be beneficial and prevented occurrances of acute relapses, as well as decrease of respiratory functional parameters values.
Pneumonol Pol 1989 Jan
PMID:[Allergic alveolitis in rural inhabitants]. 281 51

The aim of the study was to evaluate the protease and antiprotease activity in the fluid obtained from the culture of cells isolated from the lungs of animals with experimental emphysema. An attempt was made to correlate the results of biochemical examinations with adherence degree and ultrastructural changes of the surface of BAL-isolated cells. The experiment was carried out on male Wistar rats, of 180-220 g b.w. Two i.p. injections of BCG-vaccine (4 x 10(8) microorganisms) on the 1st and 14th day were applied as macrophage mobilizing and activating agent. Papain (2 mg/l ml/100 g b.w.) was given once i.t. on the 21st day. The animals were sacrificed on the 28th day of the experiment. We found a correlation between the increase in the cell adherence and ultrastructural changes (in SEM), suggesting an increased activity of the cells isolated from BCG-treated rats. In the culture medium of cells isolated from the rats which were given BCG or papain and BCG+papain we observed an increased base protease activity and decreased Cathepsin D activity comparing with the control group. Increased antitrypsin activity in the BCG and BCG+papain-treated rats and decreased antitrypsin activity in papain-treated rats only was observed, too. There was no obvious difference in the levels of the antiplasmin and antichymotrypsin activities between the groups. The present results indicate that activated pulmonary macrophages are one of the sources of the protease-antiprotease intraalveolar imbalance. However, an increased production of proteolytic enzymes may not be the only factor responsible for the progression of lung emphysema in BCG-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Pol J Pathol 1995
PMID:Comparison of morphological and biochemical changes of BAL-isolated cells in experimental lung emphysema. 749 38

Airway inflammation is a prominent feature of chronic airway disease as asthma and chronic bronchitis. Multiply cells released mediators and neurotransmitters which are likely to be involved in their origination. The purpose of this study was to establish the levels of kinin, albumin, TAME-esterase activity in BAL fluid of symptomatic and asymptomatic asthmatic patients and to determinate the relationship among mediators. There were significant increases in the mean concentrations of kinin, HSA, TAME-esterase activity in BAL fluid from patients with asthma, chronic bronchitis, compared with the controls (p < 0.005). Kinin mean concentration was in asthmatics 5313, 2 ng/ml, in chronic bronchitis patients 6796.2 ng/ml, versus 468.1 ng/ml in control group. TAME-esterase activity in investigated group was as follow asthmatics 12666 cmp, CB 15131, 3 cmp, versus 3695, 5 cmp in controls. We observed good correlation of kinin and TAME-esterase with HSA in BAL fluid suggest vascular origin of the mediators. The presence of kinins, TAME-esterase in BALs from symptomatic asthmatics and patients with chronic bronchitis provide strong evidence that kinins are involved in this group of lower airway diseases.
Pneumonol Alergol Pol 1995
PMID:[Evaluation of bradykinin levels and activation of Tame-esterase in Bronchial alveolar lavage fluid of patients with bronchial asthma]. 758 Oct 56

Bronchoscopy was carried out in 32 HIV seropositive patients, most with AIDS during the period between January 1992 and August 1993. In 14 patients tuberculosis was diagnosed, in 13 it was bacteriologically confirmed. The mean age of the examined patients was 35.5 years (range 22-49 years). In 50% of the BAL samples bacterioscopy was positive. Bacteriological examination of the sputum and BAL fluid (bacterioscopy and culture) produced a confirmation of tuberculosis in 99.9% of the cases.
Pneumonol Alergol Pol 1995
PMID:[The role of bronchoscopy and bronchoalveolar lavage in diagnosis of pulmonary tuberculosis in AIDS]. 763 65

The effect of BAL and fiberoptic bronchoscopy on gasometric and spirometric parameters was studied in 22 patients with sarcoidosis and 15 volunteers. In 12 patients with sarcoidosis during the repeated BAL procedure the effect of oxygen supplementation (by nasal prongs 3 L/min) was analysed. Significant decrease of oxygen pressure (PaO2) and vital capacity was seen in patients undergoing BAL and fiberoptic bronchoscopy. The administration of oxygen during the BAL procedure prevented the fall in oxygen pressured.
Pneumonol Alergol Pol 1994
PMID:[Effect of bronchoalveolar lavage (BAL) on gasometric and spirometric parameters in patients with sarcoidosis]. 771 62

In 30 patients aged 41-68 with peripheral tumors of lung bronchofiberoscopy, BAL, sputum cytology and thin needle biopsy (TNB) were evaluated. It was found very high sensitivity and specificity of TNB in recognition of peripheral tumors of lung.
Pneumonol Alergol Pol 1994
PMID:[Usefulness of fine needle biopsy in diagnosis of peripheral lung tumors]. 807 13


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