Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.2.1.7 (
BAL
)
1,977
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Histidine-rich glycoprotein
(
HRG
) is an enigmatic glycoprotein able to interact with a variety of ligands such as IgG, complement components, heparan sulfate, thrombospondin, fibrinogen and plasminogen.
HRG
is present at high concentrations in plasma and there is evidence indicating that it is able to modulate the course of biological processes such as angiogenesis, fibroblast proliferation, complement activation, coagulation and fibrinolysis. Because these processes are involved in the pathogeneses of lung fibrosis we here analyzed a possible link between
HRG
and idiopathic pulmonary fibrosis (IPF). We found that plasma concentrations of
HRG
are significantly diminished in IPF patients compared to healthy subjects. Moreover, we found a positive correlation between
HRG
plasma levels and forced vital capacity (FVC) values, suggesting that plasma concentration of
HRG
would be a useful indicator of disease activity in IPF.
HRG
has been described as a negative acute phase reactant able to accumulate at sites of tissue injury. Hence, we also measured the concentrations of
HRG
in
BAL
samples from IPF patients. We found that the concentrations of
HRG
in samples from IPF patients were significantly higher compared to controls, suggesting that the reduced concentration of
HRG
in plasma from IPF patients could be due, at least in part, to an enhanced uptake of this protein in the lung.
...
PMID:Histidine-rich glycoprotein and idiopathic pulmonary fibrosis. 2652 73
