Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.2.1.7 (
BAL
)
1,977
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Plasma protein exudation into the airways is an important pathophysiological event in asthma. The effect of 12 wk of treatment with inhaled fluticasone propionate (FP; 250 microgram twice a day) or salbutamol (Sb; 400 microgram twice a day) on plasma protein leakage was compared in a double-blind, randomized parallel-group study of 30 patients with asthma. Primary outcomes were plasma protein leakage and size selectivity of the blood-airway lumen barrier, cell differentials in
BAL
fluid, and bronchial responsiveness to histamine (PC20histamine). Two independent procedures to account for the effect of variable dilution of
BAL
on the levels of albumin (Alb) and
alpha2-macroglobulin
(
A2M
) in
BAL
fluid consisted of correction based on urea levels and on the application of the relative coefficient of excretion [RCE = ([
A2M
] in
BAL
fluid/[
A2M
] in serum)/([Alb] in
BAL
fluid/[Alb] in serum)]. In the FP group a significant decrease was found in the
A2M
level and the RCE, and in the percentage of eosinophils in
BAL
fluid. The PC20histamine increased significantly (mean increase, 2.4 doubling doses), whereas PC20histamine decreased in the Sb group. Differences between groups were significant except for the decrease in eosinophils. We conclude that 12 wk of FP (250 microgram twice a day) decreased the permeability of the blood-airway lumen barrier, in particular for high molecular weight proteins.
...
PMID:A double-blind study on the effect of inhaled corticosteroids on plasma protein exudation in asthma. 1022 17
