Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.7 (BAL)
 1,977 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifteen asthmatic patients were prospectively selected. If they had more than 450 eosinophils in peripheral blood on admission to hospital treatment and if before BAL had been performed they were not treated by corticosteroids. No associated disease was found which could cause the increased number of eosinophils in peripheral blood except bronchial asthma. BAL was performed when the subjects tested had no dyspnea, usually 1-3 days after the hospital admission. In contrast to blood eosinophilia, increase of eosinophils number in BAL was found to correlate to impairment of clinically measured parameters such as: ventilation level of blood gases and duration of hospitalisation. On the contrary there was no correlation between the level of blood eosinophilia and gas disturbance and duration of hospitalisation. Eosinophilic proteins (MBP, ECP, EPX, EPO) are not the only that harmfully effect the lung cells in the asthmatic attack but the fact that their level in lavage fluid correlates to eosinophilia degree in BAL is evident so the correlation between the number of eosinophils in BAL and impairment of clinically measured parameters is clear.
 ...
PMID:[Evidence of the harmful effects of eosinophils in bronchial asthma]. 221 19

Five lines of evidence support the hypothesis that the eosinophil, possibly through its granule proteins, mediates bronchial hyperreactivity. First, bronchial hyperreactivity and blood eosinophilia are associated in patients with asthma. Second, bronchial hyperreactivity is associated with the number of eosinophils and the levels of eosinophil granule MBP in BAL fluids. Third, direct instillation of MBP into the lungs of monkeys caused bronchospasm and increased reactivity to methacholine. Fourth, direct application of MBP to respiratory epithelium caused increased smooth muscle reactivity to acetylcholine, suggesting that MBP stimulates respiratory epithelium to produce factors active on smooth muscle. Fifth, MBP causes allosteric inhibition of lung M2 muscarinic receptors.
 ...
PMID:Bronchial hyperreactivity and eosinophil granule proteins. 836 65

It has been known that eosinophilia in the peripheral blood or tissue participate in allergic inflammatory reactions and parasitic diseases. The function of eosinophils depend on the biological activity of the granule proteins. Four of these protein-MBP, ECP, EPO, and EDN have been known. There are some assumptions that the eosinophils might cause a tissue damage on examination of their specific protein. Therefore, the measurements of these granule proteins might clarify the pathogenesis of eosinophils related diseases. In this review, we introduce a convenient method for purification, quantitative measurement in serum, BAL and detection of localization in tissue by an immunofluorescence method for specific staining of eosinophil granule proteins.
 ...
PMID:[The measurement of eosinophil granule proteins]. 849 49

Tropical Pulmonary Eosinophilia (TPE) is a severe form of allergic asthma caused by the host inflammatory response to filarial helminths in the lung microvasculature, and is characterized by pulmonary eosinophilia, increased filarial-specific IgG and IgE antibodies, and airway hyperresponsiveness. The current study examined the effect of IL-12 on pulmonary eosinophilia, deposition of eosinophil major basic protein and airway hyperresponsiveness in mice inoculated i.v. with Brugia malayi microfilariae. Injection of recombinant murine IL-12 modulated the T helper (Th) response in the lungs from Th2- to Th1-like, with elevated IFN-gamma, and decreased IL-4 and IL-5 production. Consistent with this shift in cytokine response, antigen-specific IgG2a was elevated, and IgG1 and total serum IgE were decreased. In addition, eosinophils in BAL fluid from IL-12 treated mice were reduced from 56% to 11%, and there was no detectable MBP on respiratory epithelial cells. Importantly, IL-12 suppressed airway hyperresponsiveness compared with saline-injected control animals. Taken together, these data clearly demonstrate that by modulating Th associated cytokine production, IL-12 down-regulates filaria-induced lung immunopathology.
 ...
PMID:Interleukin-12 suppresses filaria-induced pulmonary eosinophilia, deposition of major basic protein and airway hyperresponsiveness. 979 6