Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.7 (BAL)
 1,977 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The database for the acute health effects of common outdoor air pollutants is rapidly increasing but important gaps still exist. Greater technical efforts and innovative studies are required to adequately characterize health effects and understand the underlying mechanisms of toxicity. Controlled human exposures provide relevant data about short-term effects and complement animal and epidemiologic investigations. Except for possibly nitrogen dioxide, the clinical data for ozone, sulfur dioxide, and particulates (H2SO4) at contemporary levels indicate potentially untoward or adverse physiologic or clinical responses in healthy individuals and sensitive groups such as children, adolescents, and asthmatic patients. Exercise, duration, and other exposure factors may potentiate pollutant effects on symptoms, lung function, nonspecific bronchial reactivity, mucociliary clearance, and BAL markers of inflammation. Continued animal, clinical, and epidemiologic research of both short- and long-term health effects is clearly needed to support or limit future regulatory decisions regarding the quality of outdoor air.
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PMID:Health effects of air pollution. A review of clinical studies. 151 49

When cell-free preparations of Chlorella pyrenoidosa Chick (Emerson strain 3) form thiosulfate from labeled sulfate, another radioactive compound also appears. This compound has been isolated in quantity and is shown to be identical with adenosine-3'-phosphate-5'-phosphosulfate (PAPS) on the basis of its chromatographic and electrophoretic behavior, chemical composition, sensitivity to selective degradative enzymes, and its ability to serve as a substrate for rat liver aryl sulphotransferase. In addition, as expected for PAPS, the compound on mild acid treatment yields all of its radioactive sulfur as sulfate, and is converted to a compound identical with adenosine-3',5'-diphosphate (PAP). Replacement of sulfate and ATP by this PAP(35)S in the usual incubation mixture yields the same product, thiosulfate, which can be isolated as such or detected as acid-volatile radioactivity. This conversion of PAP(35)S to thiosulfate still requires the addition of Mg(2+) and a reductant such as 2,3-dimercaptopropan-1-ol (BAL). The cause of our previous result that high concentrations of ATP inhibit thiosulfate formation from sulfate can be ascribed to a small amount of PAP contaminating the ATP preparations, since PAP proves to be an exceedingly effective inhibitor of the conversion of PAP(35)S to thiosulfate. Sulfate reduction to thiosulfate by Chlorella extracts is discussed and compared with similar systems from other organisms.
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PMID:Studies of Sulfate Utilization by Algae. 6. Adenosine-3'-Phosphate-5'-Phosphosulfate (PAPS) as an Intermediate in Thiosulfate Formation From Sulfate by Cell-Free Extracts of Chlorella. 1665 7