Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.7 (BAL)
 1,977 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The neovascularization is a known event in the de development of tumors. The progressive growth of solid tumors is strictly dependent on angiogenesis. Furthermore, shedding of tumor cells into the circulation is not observed in a prevascular phase of tumors. Therefore, the inhibition of angiogenesis could be a good target for cancer control. Lymphocytes from, tumor bearing-mice were capable of inducing neovascular response in the skin of syngeneic mice. This response was named syngeneic lymphocyte-induced angiogenesis (SLIA). This work was an attempt to study if two proteins present in extracellular matrix, collagen and fibronectin (FN), could modulate lymphocyte-induced angiogenesis. The angiogenic response induced by lymphocytes from S13 tumor bearing-nice in the skin of BAL/c mice was blocked by treatment with FN and Gly. Arg. Gly. Asp. peptide. On the contrary, collagen and Gly. Arg. Gly. Asp. Ser did not modify SLIA response.
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PMID:[Modulation of angiogenesis induced by lymphocytes by extracellular matrix proteins]. 754 77

Multifunctional, topological template molecules such as linear and cyclic peptides have been used for the attachment of peptide strands to form novel protein models of, for example, 4-alpha-helix bundles. The concept of carbohydrates as templates for de novo design of potential protein models has been previously described and these novel chimeric compounds were termed carbopeptides. Here, a second generation strategy in which carbopeptides are synthesized by chemoselective ligation of a peptide aldehyde to an aminooxy-functionalized alpha-D-galactopyranoside is described. This template was prepared by per-O-acylation of methyl alpha-D-galactopyranoside with N,N-Boc2-aminooxyacetic acid to form a tetra-functionalized template, followed by treatment with TFA-CH2Cl2 to release the aminooxy functionality. The peptide aldehydes Fmoc-Ser-Gly-Gly-H and H-Ala-Leu-Ala-Lys-Leu-Gly-Gly-H were synthesized by a BAL strategy. Four identical copies of peptide aldehyde were smoothly attached to the template by chemoselective ligation to form a 2.1 and a 2.9 kDa carbopeptide, respectively.
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PMID:Carbopeptides: chemoselective ligation of peptide aldehydes to an aminooxy-functionalized D-galactose template. 1091 9