Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.2.1.7 (
BAL
)
1,977
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of canavanine and 2,3-dimercapto-1-propanol (British antilewisite,
BAL
) on the uptake of (3H)-thymidine by Novikoff hepatoma cells, as a measure of DNA formation, was measured in tissue culture in the absence and presence of the mitogen, concanavalin A (Con A).
Canavanine
and Con A stimulated cell proliferation at low concentrations, and inhibited at higher concentrations.
BAL
inhibited even at low concentrations. In the presence of a stimulating concentration of Con A, both canavanine and
BAL
inhibitory effects were amplified. In the presence of a high concentration of Con A and low concentration of
BAL
the combined effect was substantially greater than the sum of the individual effects. We describe the culture and harvest of Novikoff hepatoma cells, and changes in their morphology when acted upon by the toxic agents used.
...
PMID:Effect of canavanine and 2,3-dimercapto-1-propanol (British antilewisite) on the proliferation of Novikoff hepatoma cells in the presence of concanavalin A. 668 93
