Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.2.1.7 (
BAL
)
1,977
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kinetic of cotrimoxazole was studied in serum, alveolar macrophages and
BAL
fluid from guinea pigs receiving sulfamethoxazole (SMX, 100 mg/kg) and trimethoprim (
TMP
, 20 mg/kg). Guinea pigs were killed by cervical dislocation 30 min, 1 h, 3 h, 6 h and 24 h after intraperitoneal injection. Lung lavage was performed to obtain alveolar macrophages and
BAL
fluid.
TMP
and SMX levels were assayed using high-performance-liquid chromatography. Highest SMX levels were obtained in serum at 30 min, in
BAL
fluid at 1 h and in alveolar macrophages at 3 h. Mean SMX/
TMP
ratios (30 min, 1 h, 3 h) was 26.5 +/- 0.8 in serum, 3.76 +/- 1.8 in
BAL
fluid and 1.15 +/- 0.02 in alveolar macrophages.
...
PMID:[Study of the in vivo penetration of cotrimoxazole in alveolar macrophages]. 237 89
