Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.7 (BAL)
 1,977 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A survey of 109 pulmonary physicians representing both private practice and academic medicine was conducted to learn their practice of management and treatment of interstitial lung disease. Of the 109, 25 (23 percent) responded. Twenty-two of 23 routinely obtain tissue diagnosis. The routine method was transbronchial biopsy by 15 physicians vs open lung biopsy by seven. Few (n = 5) use BAL cell analysis. The majority of clinicians used two to four criteria to initiate therapy. Physiology laboratory data were the predominant criteria used by the majority of physicians and also were most commonly used to monitor a patient's course over time. Prednisone was the drug of choice for therapy. Immunosuppressive therapy was not used until failure of steroid therapy was observed. There was little consistency in the diagnostic procedures applied, criteria for the decision to treat, the drugs used to treat, or methods for monitoring.
 ...
PMID:Management for interstitial lung disease. State of the art. 292 May 97

In 29 patients with chronic allergic alveolitis broncho-alveolar lavage BAL and lung function tests were performed before and after one year of Prednisone treatment. We observed significantly (p < 0.001) decrease of BAL lymphocytes from 52% to 32% and significantly (p < 0.001) increase of BAL macrophages from 33% to 54%. We found negative correlation between percentage of BAL neutrophils before treatment and annual changes of DLCO (r = 0.37 p < 0.05). Annual changes of lymphocytes negatively correlated with annual changes of DLCO (r = 0.45 p < 0.02) and D/VA (r = 0.46 p < 0.02).
 ...
PMID:[Evaluation of the usefulness of bronchoalveolar lavage for prognosing and monitoring the treatment of patients with chronic allergic alveolitis]. 875 59

The aim of this study was to analyse frequency, type and course of fungal infection in patients treated with heart transplantation (HT) and to estimate the efficacy of diagnostic procedures in patients before and after HT. The study was conducted on 30 patients (group I) aged 20-64 referred for HT and treated after HT in Coronary Disease Department in Cracow. Standard immunosuppressive protocol consisting of CSA-A, Aza, Prednisone was administered to all recipients after HT. As a control group 40 healthy persons aged 25-65 were examined. In all persons quantitative and mycoserological examinations were carried out according to a special protocol. In some justified cases despite serological and quantitative examinations, bronchoscopy with BAL, biopsy procedure, histological examination of tissue were performed in patients after HT. The commonest infections in patients after HT were oropharyngeal Candida infections. They mostly occurred in the first months after HT, and were observed in 67% of recipients. Besides, in two patients deep Aspergillus infections were documented. Quantitative mycological examinations were very useful in diagnosing early stages of superficial mycoses. In none of these patients before HT were permanent oropharyngeal yeast and Aspergillus colonizations observed. Diagnosis of deep Aspergillus mycoses was difficult. Even antigen detection did not allow for making definitive diagnosis, because antigen was found in some recipients without infections and in some healthy persons. Definitive diagnosis depended on histological and mycological examinations of tissue sections obtained by surgical procedure and in second case by autopsy.
 ...
PMID:Opportunistic fungal infections in patients treated with heart transplantation--own centre experiences. 1023 31

A 59-year-old woman was admitted to hospital 10 months after receiving a liver transplant (LT) for hepatitis C virus (HCV) cirrhosis because of fever, dyspnea and basal patchy peripheral infiltrates. Microscopic examinations and blood, sputum and BAL cultures were negative. Empirical anti-infective therapy was ineffective. Thoracoscopic lung biopsy was performed, and histology showed a pattern suggesting bronchiolitis obliterans organizing pneumonia (BOOP). Prednisone led to rapid clinical and radiologic improvement. BOOP has been anecdotally reported in LT cases, and this case was unrelated to any infectious agent. BOOP should be taken into account in the differential diagnosis of pneumonia in LT.
 ...
PMID:A 59-year-old liver-transplanted woman with fever, dyspnea and pulmonary infiltrates. 1461 53