Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.7 (BAL)
 1,977 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

80 patients with chronic bronchitis were treated inhalatively for a time of 3 weeks with a polyvalent bacterial lysate (IRS 19) or with placebo. The study was carried out in a double-blind fashion. Treatment with IRS 19 resulted in improved bronchoscopic findings compared with the pretherapy findings. Patients with bronchial hyperreactivity showed in the IRS 19 group small improvement of the hyperreactivity. In this group the contents of IgG in the BAL fluid showed a significant reduction, the other parameters were unchanged.
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PMID:[Inhalative immunostimulation in patients with chronic bronchitis]. 307 83

In previous experiments, an origin of viral DNA replication was localized within a 995-bp DNA fragment that mapped entirely within the TRS/IRS repeated region of the herpes simplex virus type 1 genome (N. D. Stow, EMBO J. 1, 863-867, 1982). In this paper, this origin is now shown to reside within a 535-bp segment subcloned from the above fragment. Deletions extending various distances into each end of the 535-bp segment were generated using nuclease BAL 31, and the resulting plasmids screened for their ability to replicate in cells superinfected with wild-type HSV-1 helper virus. This analysis indicated that the cis-acting sequences essential for DNA replication were present within a 90-bp region, and a 100-bp viral DNA fragment containing all the signals necessary for origin function was identified. The origin lies within an untranscribed region located between the 5'-ends of two divergently transcribed immediate-early mRNAs. A prominant feature of the origin region is an almost perfect palindromic sequence 45 bp long containing 18 consecutive A or T residues at its center.
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PMID:Characterization of the TRS/IRS origin of DNA replication of herpes simplex virus type 1. 631 38