Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.2.1.7 (
BAL
)
1,977
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The acute lymphoblastic cell lines designated
BAL
-KHc and
BAL
-KHs were established from the peripheral blood of a Japanese female patient with a B-cell acute lymphoblastic leukemia. The
BAL
-KHc and
BAL
-KHs exhibited B-cell characteristics with positive cell markers for CD19, CD20,
CD21
and HLA-DR antigens. Immunoglobulin with gamma and kappa chains was demonstrated on the cultured and fresh leukemia cells respectively. The cells lacked the Epstein-Barr virus genome and expressed abnormal chromosome constitutions including a t(8;14)(q24;q32). These results suggested that the cell lines present B-cell characteristics. The
BAL
-KHc cells showed different cell growth characteristics and cell surface marker profile compared to those of the
BAL
-KHs. These variations suggest that the
BAL
-KHc cells were probably frozen at a different stage of B-cell maturation from those of
BAL
-KHs, although both cell lines originated from the cells in the same peripheral blood sample of the patient.
...
PMID:Human acute lymphoblastic leukemia cell lines with characteristics of intraclonal variation in B-cell differentiation stage. 270 74
Rationale:
A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mice and humans with infections or autoimmune diseases. Because depletion of these cells might be valuable in patients with certain lung diseases, the goal was to find out if ABC-like cells were at elevated levels in such patients.
Objectives:
To measure ABC-like cell percentages in patients with lung granulomatous diseases.
Methods:
Peripheral blood and
BAL
cells from patients with sarcoidosis, beryllium sensitivity, or hypersensitivity pneumonitis and healthy subjects were analyzed for the percentage of B cells that were ABC-like, defined by expression of CD11c, low levels of
CD21
, FcRL 1-5 (Fc receptor-like protein 1-5) expression, and, in some cases, T-bet.
Measurements and Main Results:
ABC-like cells in blood were at low percentages in healthy subjects and higher percentages in patients with sarcoidosis as well as at high percentages among
BAL
cells of patients with sarcoidosis, beryllium disease, and hypersensitivity pneumonitis. Treatment of patients with sarcoidosis led to reduced percentages of ABC-like cells in blood.
Conclusions:
Increased levels of ABC-like cells in patients with sarcoidosis may be useful in diagnosis. The increase in percentage of ABC-like cells in patients with lung granulomatous diseases and decrease in treated patients suggests that depletion of these cells may be valuable.
...
PMID:Age-associated B Cells Appear in Patients with Granulomatous Lung Diseases. 3260 92
