Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.7 (BAL)
 1,977 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a case of PAP which proved to be fatal despite whole lung lavage. The need for early BAL and transbronchial biopsies in diffuse infiltrative lung disorders of unknown etiology is highlighted. The occurrence of PAP in association with Fanconi's anemia and psoriasis raises the possibility of a common pathogenetic defect which may be related to abnormal cytokine metabolism. Investigation of cytokine metabolism in PAP is warranted.
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PMID:Pulmonary alveolar proteinosis in association with Fanconi's anemia and psoriasis. A possible common pathogenetic mechanism. 164 65

Sarcoidosis is a multisystem granulomatous disorder of unknown etiology, predominantly affecting the lung. The increased concentration of pulmonary lymphocytes with specific receptors in subgroups of sarcoidosis patients suggests a local specific immune response. pso p27, a psoriatic scale antigen linked to the pathogenesis of psoriasis, was previously found in BAL cells, serum, and Kveim-Siltzback test in sarcoidosis. With an enzyme-linked immunoassay based on murine monoclonal antibodies, we analyzed BAL fluid from 21 patients with pulmonary sarcoidosis. Eleven (52%) of the patients have detectable levels of pso p27 antigen. No antigen is detected in the BAL fluid from five healthy, nonsmoking controls. Serum concentrations of pso p27 shows no significant difference between the two groups, but three of the sarcoidosis patients have detectable levels of the antigen. Mean concentration of pso p27 is >100 fold higher in BAL fluid than in serum from the sarcoidosis patients. This strongly suggests local pulmonary production of pso p27 antigen.
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PMID:Detection of psoriasis-associated antigen pso p27 in sarcoidosis bronchoalveolar lavage fluid using monoclonal antibodies. 880 46

A 67-year-old male presented with cutaneous rash, lassitude and fatigue of three weeks. Personal history included psoriasis and sarcoidosis. Physical examination revealed macular rash on the anterior chest wall. Laboratory results were within normal limits. Chest X-ray showed normal findings. Pulmonary function tests demonstrated a mild obstructive pattern and a mild decrease in DLCO/VA. Thorax CT revealed two nodules in the right upper and middle lobe. 68Ga-citrate PET/CT did not demonstrate any active inflammatory reaction associated with sarcoidosis while 18F-FDG PET/CT revealed increased FDG uptake in the right middle lobe, upper division bronchus and in the left lower abdominal quadrant. Histopathologic examination of the colon biopsy was compatible with adenocarcinoma and bronchoscopic biopsy of the lung lesions revealed nonspecific granulomatous inflammation. BAL cytology was normal while BAL culture did not grow any pathologic organisms. Simultaneous use of 18F-FDG and 68Ga-citrate PET/CT was the hallmark for the final diagnosis in our patient. While FDG/PET has detected the pulmonary and colonic malignant foci in our patient, 68Ga-citrate PET/CT excluded the presence of active granulomatous inflammation of sarcoidosis. Simultaneous utility of these two imaging modalities in patients with sarcoidosis is of great importance in terms of guiding the clinician towards the accurate diagnostic pathway which is the hallmark for final diagnosis, especially in the presence of concomitant malignant disease.
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PMID:Simultaneous use of FDG-18 and <sup>68</sup>Ga-citrate PET/CT for the differential diagnosis of sarcoidosis and malignant disease. 3272 28