Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.2.1.7 (
BAL
)
1,977
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The acute lymphoblastic cell lines designated
BAL
-KHc and
BAL
-KHs were established from the peripheral blood of a Japanese female patient with a
B-cell acute lymphoblastic leukemia
. The
BAL
-KHc and
BAL
-KHs exhibited B-cell characteristics with positive cell markers for CD19, CD20, CD21 and HLA-DR antigens. Immunoglobulin with gamma and kappa chains was demonstrated on the cultured and fresh leukemia cells respectively. The cells lacked the Epstein-Barr virus genome and expressed abnormal chromosome constitutions including a t(8;14)(q24;q32). These results suggested that the cell lines present B-cell characteristics. The
BAL
-KHc cells showed different cell growth characteristics and cell surface marker profile compared to those of the
BAL
-KHs. These variations suggest that the
BAL
-KHc cells were probably frozen at a different stage of B-cell maturation from those of
BAL
-KHs, although both cell lines originated from the cells in the same peripheral blood sample of the patient.
...
PMID:Human acute lymphoblastic leukemia cell lines with characteristics of intraclonal variation in B-cell differentiation stage. 270 74
