Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.7 (BAL)
 1,977 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An immunocompromised child developed necrotizing pneumonia with BAL cultures growing Legionella pneumophila resistant to treatment, including erythromycin and rifampicin. Ciprofloxacin and clarithromycin reversed the clinical course; their use as first-line drugs is justifiable and a high index of suspicion for the occurrence of legionellosis is warranted.
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PMID:Complicated nosocomial pneumonia due to Legionella pneumophila in an immunocompromised child. 1203 Apr 2

Legionellosis is a notified disease in Poland since 2001, but laboratory diagnostic methods were introduced even earlier, in 1997. In 2005 the 21 cases of legionellosis were reported in Poland, the incidence rate was 0.055 /100,000. The increasing trend in incidence rate was due to an active cooperation with some hospital staff and financial support from Polish Committee of Research Activity. All cases were laboratory diagnosed in National Institute of Hygiene, the only place where laboratory tests are performed. Most of the cases were diagnosed with serological tests -determination with ELISA test the anti-legionella antibodies in IgM fraction as the most recent reaction for Legionella infection, few by detection of legionella antigen in urine. All BAL specimens from several patients were negative when examined with culture method, but some were positive with PCR only. Since 1987 to 2005 the 15 foreign tourists were registered in EU countries as probably infected in Poland. Epidemiological investigation with the examination of water system for Legionella sp., cleaning and disinfection (if needed) was done in suspected hotels.
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PMID:[Legionellosis in Poland in 2005]. 1795 37

In 2006 the 89 cases and in 2005 the 21 cases of legionellosis were reported in Poland, the incidence rate was respectively 0.23 and 0.055/100 000. Legionellosis is a notified disease in Poland since 2002, but laboratory diagnostic methods were introduced even earlier, in 1997. The increasing trend in incidence rate was due to an active cooperation with some hospital staff and financial support from Polish Committee of Research Activity. The first time nosocomial Legionella infections were observed in Poland. The outbreak occurred among patients of ophthalmic ward. Five cases with pneumonia were examined by laboratory methods: for two the diagnose was confirmed, for two were presumptive, for one was not confirmed. Three persons died (two with diagnose presumptive, one with confirmed). Every registered case was laboratory examined in National Institute of Hygiene, the only place where laboratory tests were performed. Most of the cases were diagnosed with serological tests--determination with ELISA test the anti-legionella antibodies in IgM fraction as the most recent answer for Legionella infection, few by detection of legionella antigen in urine. All BAL specimens from several patients were negative when examined with culture method, but some were positive with PCR only. Since 1987 to 2006 the 17 foreign tourists were registered in EU countries as probably infected in Poland. Epidemiological investigation with the examination of water system for Legionella sp., cleaning and disinfection (if needed) was done in suspected hotels.
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PMID:[Legionellosis in Poland in 2006]. 1880 67

In 2007 the 28 cases oflegionellosis were reported in Poland, the incidence rate was 0.073/100,000, while 86 cases (incidence rate 0.23/100,000) in 2006. The decrease in number and in incidence rate was due to lower number of examined specimens from patients as the financial support from Polish Committee of Research Activity has expired. All the cases were laboratory diagnosed in National Institute of Hygiene, the only place where laboratory tests are performed. Most of them were diagnosed with serological tests--determination with ELISA test the anti-legionella antibodies in IgM fraction of serum gamma globulins, as the most recent reaction for Legionella infection. Only few cases were diagnosed by detection of legionella antigen in urine. All BAL specimens from several patients were negative when examined with culture method, but some were positive with PCR only. Two outbreaks were registered: one in a family (5 patients, 0 death) and one in hospital (4 patients, 3 death cases). Fifteen cases were connected with travel: 14 foreign travel cases, one in Poland. Since 1987 to 2007 the 17 foreign tourists were registered in EU countries as probably infected in Poland.
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PMID:[Legionellosis in Poland in 2007]. 1979 46

In 2008 the 15 cases of legionellosis were reported in Poland, the incidence rate was 0.039/100 000, while 28 (incidence rate 0.073/100 0000 in 2007 and 86 cases (incidence rate 0.23/100 000) in 2006. The decrease in number and in incidence rate was due to lower number of examined specimens from patients as the financial support from Polish Committee of Research Activity has expired. All the cases were laboratory diagnosed in National Institute of Hygiene, the only place where laboratory tests are performed. Most of them were diagnosed with serological tests -determination with ELISA test the anti-legionella antibodies in IgM fraction of serum gamma globulins, as the most recent reaction for Legionella infection. Only few cases were diagnosed by detection of legionella antigen in urine. All BAL specimens from several patients were negative when examined with culture method, but some were positive with PCR only. No outbreaks were registered: In 2005-2008 the 22 cases were connected with travel: 19 - foreign travel cases, 3 in Poland. Since 1987 to 2007 the 17 foreign tourists were registered in EU countries as probably infected in Poland.
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PMID:[Legionellosis in Poland in 2008]. 2073 Dec 21