Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.13 (acetyl-CoA synthetase)
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Human Gene/Protein
acetyl-CoA synthetase 16.0
ACSA 15.0
Acetyl-CoA synthetase 14.0
ACSS3 13.4
ACOT8 13.1
acetoacetyl-CoA synthetase 13.0
ACS1 12.8
ACSS1 12.7
ACSS2 12.7
ACAD8 12.6
CALS 12.6
PFK-A 12.4
ADP-dependent glucokinase 12.4
Pyruvate carboxylase 12.4
ACS2 12.2
Acetyl-CoA hydrolase 12.2
Pro protein 11.9
Brain acyl-CoA hydrolase 11.8
beta-alanine synthase 11.7
UDP-glucuronic acid decarboxylase 11.6
cytosolic acetoacetyl-CoA thiolase 11.4
acetaldehyde dehydrogenase 11.3
ESA1 11.2
ATP citrate lyase 11.2
CAB2 11.1
NAT10 11.0
lipoyltransferase 10.9
aconitate hydratase 10.8
ACS3 10.8
PFKM 10.7
carnitine acetyltransferase 10.7
3-hydroxybutyrate dehydrogenase 10.6
GCN5-related 10.5
KRT7 10.4
MORC 10.4
AdoHcyase 10.4
Argininosuccinate synthetase 10.3
Acyl-CoA synthetase 10.2
K74 10.2
A transferase 10.1
acyl-CoA synthetase 10.1
Sgt1 10.1
phosphoglyceromutase 9.9
beta-ketothiolase 9.9
GPD2 9.9
choline acetylase 9.8
Pyruvate kinase M2 9.8
6-phosphogluconolactonase 9.7
Phosphoglucomutase 9.7
hydroxymethylglutaryl-CoA synthase 9.6
GNAT 9.6
MRO 9.6
FAS1 9.5
ACK 9.5
UDPGT 9.4
class I histone deacetylase 9.4
LYS2 9.3
butyrobetaine 9.2
tubby 9.2
PK2 9.2
ACD 9.2
palmitoyl-CoA hydrolase 9.2
fabD 9.2
long-chain acyl-CoA dehydrogenase 9.2
pyruvate dehydrogenase complex 9.1
sirtuin 9.1
SIRT3 9.1
LDHB 9.0
nucleic acid binding protein 9.0
ACC1 9.0
ADH2 8.9
ACL 8.9
acetyl-CoA carboxylase 8.9
S-adenosyl-L-homocysteine hydrolase 8.9
SIRT5 8.8
SIRT4 8.8
sirtuin 3 8.7
pyruvate dehydrogenase 8.7
isocitric dehydrogenase 8.7
carbohydrate response element binding protein 8.7
more...
Disease
ACS1 12.0
Klebs 9.4
GS2 8.5
moderate obesity 8.3
IS2 8.2
Barth syndrome 8.1
ACD 8.1
GS1 8.0
Canavan 7.9
methylmalonic acidemia 6.7
systemic candidiasis 6.5
Goldstein 6.5
SCS 6.3
leukodystrophy 6.2
vitamin B12 deficiency 5.9
Brucella melitensis 5.7
ACP 5.6
TTP 5.6
oligodendroglioma 5.4
EDC 5.3
TTP 5.0
PHA 5.0
ALD 5.0
ADH 5.0
HSP 4.8
EMA 4.8
hairy cell leukemia 4.7
African trypanosomiasis 4.6
drunk 4.5
phenylketonuria 4.5
idiopathic thrombocytopenic purpura 4.4
FAS 4.1
meningoencephalitis 4.1
Hashimoto's thyroiditis 4.0
brain metastases 4.0
metabolic disorder 3.8
PCC 3.6
Bordetella 3.5
Hepatocellular carcinoma 3.5
brucellosis 3.5
PDB 3.4
astrocytoma 3.3
toxoplasmosis 3.3
candidiasis 3.1
Cryptococcus neoformans 3.1
bladder cancer 3.1
worms 3.1
Mycobacterium 3.0
genetic disorder 3.0
Yersinia 2.9
hyperthyroidism 2.8
malaria 2.7
liver cancer 2.6
Brown 2.5
neuroblastoma 2.3
fatty liver 2.3
pheochromocytoma 2.3
liver cancer 2.2
tuberculosis 2.2
SDS 2.1
mole 2.0
hepatocellular carcinoma 2.0
glioblastoma 1.9
tumorigenesis 1.9
pertussis 1.8
tumor growth 1.8
chronic hepatitis 1.8
primary tumor 1.8
cholera 1.8
type 1 diabetes 1.8
hypoglycemia 1.7
mole 1.7
renal cell carcinoma 1.7
cold 1.6
coronary heart disease 1.6
lung carcinoma 1.6
dehydration 1.6
cystic fibrosis 1.5
cytomegalovirus 1.3
aggression 1.3
more...
Symptom
starvation 4.1
exhaustion 2.4
acidity 2.2
hypothermia 2.0
Drug
Sodium acetate 9.4
beta-Galactosidase 7.3
Glutamic acid 7.1
ACT 6.6
Adenosine triphosphate 6.3
Lactose 6.0
Triclosan 5.5
citric acid 5.4
NADH 5.3
Ethanol 5.2
lysine 5.0
Alliance 4.7
niacin 4.2
PCB 4.1
FAD 3.7
Gel 3.2
THF 3.1
ABC 3.0
Asn 2.6
lactose 2.1
ROS 1.9
Leaf 1.7
Enzyme
acetyl-CoA synthetase 16.1
propionyl-CoA synthetase 14.1
4-chlorobenzoate:CoA ligase 13.9
CimA 13.8
acetyl-CoA hydrolase 13.5
FAEES 13.1
taurine dehydrogenase 13.1
Xsc 13.1
acetoacetyl-CoA synthetase 12.8
ADP-dependent glucokinase 12.4
phosphopantothenoylcysteine synthetase 12.4
acetate kinase 12.3
CobB 12.2
malyl-CoA lyase 11.8
PrpD 11.6
pyruvate:ferredoxin oxidoreductase 11.6
citrate cleavage enzyme 11.4
phosphoenolpyruvate synthase 11.1
citramalate synthase 11.0
homoserine transacetylase 11.0
citrate lyase 11.0
acetoacetyl-CoA reductase 11.0
malate synthase 10.9
methylisocitrate lyase 10.9
acetoacetyl-CoA thiolase 10.8
isocitrate lyase 10.7
carnitine acetyltransferase 10.7
PTA 10.7
alpha-aminoadipate reductase 10.6
pyruvate oxidase 10.6
pyruvate oxidase 10.6
zeta-carotene desaturase 10.5
maltose phosphorylase 10.5
alcohol acetyltransferase 10.5
nicotinamidase 10.3
acyl-ACP synthetase 10.3
succinyl-CoA synthetase 10.2
phospholipid:diacylglycerol acyltransferase 10.2
fatty acid elongase 10.1
acyl-CoA synthetase 10.1
acetoacetate decarboxylase 10.1
pyruvate decarboxylase 10.1
6-phosphogluconolactonase 9.6
EC 2.6.1.16 9.6
acyl-CoA synthetase 9.6
3-oxoacid CoA-transferase 9.5
acetolactate decarboxylase 9.4
ketohexokinase 9.4
CO dehydrogenase 9.3
EC 2.7.7.9 9.2
beta-hydroxybutyrate dehydrogenase 9.1
pyruvate dehydrogenase 9.1
acyl-CoA thioesterase 9.0
S-adenosyl-L-homocysteine hydrolase 9.0
EC 3.6.1.1 9.0
SCS 8.9
pyruvate dehydrogenase 8.9
pyruvate dehydrogenase 8.9
UMP kinase 8.9
LipA 8.9
arachidonate 5-lipoxygenase 8.9
acetyl-CoA carboxylase 8.9
glycerophosphate acyltransferase 8.8
HMG-CoA synthase 8.8
enoyl-ACP reductase 8.7
enoyl-ACP reductase 8.7
propionyl-CoA carboxylase 8.7
ACS 8.7
hydroxypyruvate reductase 8.7
lysine acetyltransferase 8.6
TSR 8.6
lactose synthetase 8.5
aspartoacylase 8.5
phosphoglyceromutase 8.5
hydroxypyruvate reductase 8.5
glycerol 3-phosphate dehydrogenase 8.5
EC 1.1.1.40 8.4
sulfite oxidase 8.2
6-phosphogluconate dehydrogenase 8.2
6-phosphogluconate dehydrogenase 8.2
more...
Compound
Phenylacetyl-CoA 13.1
Purpald 12.4
Aromadendrin 11.9
acetyl-CoA 11.0
Genistin 10.7
Nitrosoguanidine 10.6
Nitrosoguanidine 10.6
1-amino-2-naphthol 10.3
Phytoene 10.0
Phytoene 10.0
Methylmalonic acid 10.0
Acetyl phosphate 9.9
Succinyl-CoA 9.8
propionyl-coenzyme A 9.7
butyryl-CoA 9.6
Sodium acetate 9.4
dADP 9.1
3-hydroxybutyryl-CoA 9.1
acetoacetyl-CoA 9.0
Prodigiosin 9.0
Prodigiosin 9.0
Spiramycin 9.0
Spiramycin 8.9
CoA 8.9
L-Lactate 8.9
Geniposide 8.8
Acetyl-L-carnitine 8.3
Glycolate 8.3
Saccharin 8.1
4-Hydroxynonenal 8.1
ADP-glucose 8.0
Pyruvate 8.0
Squalene 8.0
3-hydroxybutyric acid 8.0
IDP 7.8
adenylate 7.8
Propionate 7.7
isocitrate 7.7
PPi 7.7
alcohol dehydrogenase 7.6
Glucose 6-phosphate 7.6
PAE 7.5
2,3-butanediol 7.5
2,3-butanediol 7.5
2,3-butanediol 7.5
Pyruvate kinase 7.3
acetaldehyde 7.3
tetraphosphate 7.3
acetate 7.3
malonyl-CoA 7.2
Xylose 7.2
PDH 7.1
Acyl-CoA 7.1
Coenzyme A 7.0
HOG 7.0
2-butanol 7.0
Malate 7.0
DHBA 6.9
Ferulic acid 6.9
Ferulic acid 6.9
Isoform 6.9
NAD 6.8
oxalacetate 6.6
CBS 6.6
NAD 6.6
PTS 6.5
L-carnitine 6.5
Triclosan 6.5
TCA 6.4
POA 6.4
pentose 6.4
pentose 6.3
pentose 6.3
acetic acid 6.3
pentose 6.3
2-oxoglutarate 6.2
NADP 6.2
AMP 6.2
phthalaldehyde 6.1
ITP 6.1
more...