Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.2.1.13 (
acetyl-CoA synthetase
)
451
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Formation of acetyl-CoA through
acetyl-CoA synthetase
(forward reaction) and through choline acyltransferase (backward reaction) was investigated in tissue extract from the electric organ of Torpedo marmorata. When the tissue extract was submitted to gel filtration on Sephadex G-25, the formation of acetyl-CoA by
acetyl-CoA synthetase
appeared fully dependent on ATP and CoA and partially dependent on acetate (an endogenous supply of acetate is discussed).
Choline acetyltransferase
was a potent source of acetyl-CoA, only requiring acetylcholine and CoA, and was much more efficient than
acetyl-CoA synthetase
for concentrations of acetylcholine likely to be present in nerve endings.
...
PMID:Biosynthesis of acetyl-coenzyme A in the electric organ of Torpedo marmorata in relation to acetylcholine metabolism. 2 1
