Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.2.1.1 (
ACS
)
78,556
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In order to assess the potential of sPLA
2
-X as a therapeutic target for atherosclerosis, novel sPLA
2
inhibitors with improved type X selectivity are required. To achieve the objective of identifying such compounds, we embarked on a lead generation effort that resulted in the identification of a novel series of indole-2-carboxamides as selective
sPLA2-X
inhibitors with excellent potential for further optimization.
ACS
Med Chem Lett 2018 Jul 12
PMID:Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A
2
Type X (sPLA
2
-X) Inhibitors. 3003 85
