Gene/Protein Disease Symptom Drug Enzyme Compound
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Structure determination by transmission electron microscopy has revealed the long sought 144-gold atom particle. The structure exhibits deviations from face-centered cubic packing of the gold atoms, similar to the solution structure of another gold nanoparticle, and in contrast to a previous X-ray crystal structure. Evidence from analytical methods points to a low number of 3-mercaptobenzoic acid ligands covering the surface of the particle.
ACS Nano 2017 12 26
PMID:Structure Determination of a Water-Soluble 144-Gold Atom Particle at Atomic Resolution by Aberration-Corrected Electron Microscopy. 2913 69

Probing changes of noncovalent interactions is crucial to study the binding efficiencies and strengths of (bio)molecular complexes. While surface-enhanced Raman scattering (SERS) offers unique molecular fingerprints to examine such interactions in situ, current platforms are only able to recognize hydrogen bonds because of their reliance on manual spectral identification. Here, we differentiate multiple intermolecular interactions between two interacting species by synergizing plasmonic liquid marble-based SERS platforms, chemometrics, and density functional theory. We demonstrate that characteristic 3-mercaptobenzoic acid (probe) Raman signals have distinct peak shifts upon hydrogen bonding and ionic interactions with tert-butylamine, a model interacting species. Notably, we further quantify the contributions from each noncovalent interaction coexisting in different proportions. As a proof-of-concept, we detect and categorize biologically important nucleotide bases based on molecule-specific interactions. This will potentially be useful to study how subtle changes in biomolecular interactions affect their structural and binding properties.
ACS Appl Mater Interfaces 2020 Jul 22
PMID:In Situ Differentiation of Multiplex Noncovalent Interactions Using SERS and Chemometrics. 3257 74