Gene/Protein Disease Symptom Drug Enzyme Compound
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A device composed of a poly (N-isopropylacrylamide)-co-acrylic acid (pNIPAm-co-AAc) microgel layer sandwiched between two thin Au layers (all on a glass support) was used as a novel platform for controlled and triggered small molecule delivery. Tris (4-(dimethylamino)phenyl)methylium chloride (Crystal Violet, CV), which is positively charged, was loaded into the microgel layer of the device and released in a pH dependent fashion, at a rate that could be controlled by the thickness of the Au layer coating the microgels. Specifically, at pH 6.5 (above the pKa for AAc) the microgels were negatively charged, promoting the strong interaction between the CV and the microgels, hindering its release from the layer. At pH 3.0 the microgel's AAc groups are protonated making the microgel mostly neutral, allowing CV to be released from the microgel layer at a rate that depends on the thickness of the Au covering the microgels. Specifically, devices with thin Au overlayers on the microgel layer allow CV to be released from the device faster than devices with thick Au overlayers. The ability to tune the release rate with pH and Au layer thickness is advantageous for developing implantable devices that are capable of releasing small molecule drugs in a triggered and controlled fashion.
ACS Appl Mater Interfaces 2013 Oct 09
PMID:Controlled and triggered small molecule release from a confined polymer film. 2406 61

The study describes the synthesis of two porous hybrid polymers (abbreviated as DPPF-HPP and DPPOF-HPP) from the Friedel-Crafts reaction of octavinylsilsesquioxane with 1,1'-bis(diphenylphosphine)ferrocene (DPPF) and 1,1'-bis(diphenylphosphine oxide)ferrocene (DPPOF), respectively. DPPF-HPP and DPPOF-HPP possess surface areas of about 890 and 780 m2 g-1, respectively, as well as similar pore structures of the coexisting micropores and mesopores. They are excellent materials for high adsorption of different dyes with adsorption capacities of 2280 mg g-1 for Congo Red and 1440 mg g-1 for Crystal Violet. DPPF-HPP also shows a strong affinity to adsorb Hg2+ ions (300 mg g-1). These materials show no sign of degradation under repeated cycles and thus offer potential for wastewater treatment.
ACS Appl Mater Interfaces 2019 Jul 24
PMID:Diphenylphosphine-Substituted Ferrocene/Silsesquioxane-Based Hybrid Porous Polymers as Highly Efficient Adsorbents for Water Treatment. 3125 24

The wavelength-dependent complex linear polarizability of a dye is a crucial input for the modeling of the optical properties of dye-containing systems. We here propose and discuss methods to obtain an accurate polarizability model by combining absorption spectrum measurements, Kramers-Kronig (KK) tranformations, and density functional theory (DFT) calculations. We focus, in particular, on the real part of the polarizability and its link with static polarizability. In addition, we introduce simple KK-consistent analytic functions based on the theory of critical points as a much more accurate approach to model dye polarizabilities compared with existing models based on Lorentz oscillators. Accurate polarizability models based on critical points and DFT calculations of the static polarizability are derived for five commonly used dyes: Rhodamine 6G, Rhodamine 700, Crystal Violet, Nile Blue A, and Methylene Blue. Finally, we demonstrate explicitly, using examples of Mie Theory calculations of nanoparticle-dye interactions, how an inaccurate polarizability model can result in fundamentally different predictions, further emphasizing the importance of accurate models, such as the one proposed here.
ACS Omega 2017 May 31
PMID:Accurate Modeling of the Polarizability of Dyes for Electromagnetic Calculations. 3145 44

Reactive oxygen species (ROS) can degrade organic compounds and function as a broad-spectrum disinfectant. Here, dopamine methacrylamide (DMA) was used to prepare catechol-containing microgels, which can release ROS via metal-catechol interaction. A combination of the microgel and iron magnetic nanoparticle (FeMNP) significantly reduced the concentration of four organic dyes (Alizarin Red S, Rhodamine B, Crystal Violet, and Malachite Green) and an antibiotic drug, ciprofloxacin, dissolved in solution. Degradation of dye occurred across a wide range of pH levels (pH 3-9). This simple combination was also antimicrobial against both Escherichia coli and Staphylococcus aureus. Electron paramagnetic resonance spectroscopy (EPR) results indicate that singlet oxygen was generated during the reaction between catechol and FeMNP at both pH 3 and 7.4, which was responsible for the degradation of organic compounds and bactericidal features of the microgel. Unlike autoxidation that only occurs at a neutral to basic pH, FeMNP-induced catechol oxidation generated singlet oxygen over a wide range of pH level. Additionally, catechol chelates heavy metal ions, resulting in their removal from solution and repurposed these metal ions for dye degradation. This multifunctional microgel can potentially be used for environmental applications for the removal of organic pollutants and heavy metal ions from wastewater, as well as reducing bacterial infection in biomedical applications.
ACS Appl Mater Interfaces 2020 May 13
PMID:Iron Magnetic Nanoparticle-Induced ROS Generation from Catechol-Containing Microgel for Environmental and Biomedical Applications. 3206 6