Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.1 (ACS)
 78,556 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

ZnO:Mn nanostructures are important diluted magnetic materials, but their electronic structure and magnetic origin are still not well understood. Here we studied the time-delayed and power-dependent photoluminescence spectra of Mn(II) doped ZnO nanowires with very low Mn concentration. From the time-delayed emission spectra, we obtained their electronic levels of single Mn ion replacement of Zn ions in ZnO nanowire. The high d-level emissions show up unusually because of the stronger p-d hybridization than that in ZnS, as well as the spin-spin coupling. After increasing Mn doping concentration, the ferromagentic cluster of the Mn-O-Mn with varied configurations can form and give individual emission peaks, which are in good agreement with the ab initio calculations. The presence of clustered Mn ions originates from their ferromagnetic coupling. The lifetimes of these d levels show strong excitation power-dependent behavior, indication of strong spin-dependent coherent emission. One-dimensional structure is critical for this coherent emission behavior. These results indicate that the d state is not within Mn ion only, but a localized exciton magnetic polaron, Mn-O-Mn coupling should be one source of ferromagnetism in ZnO:Mn lattice, the latter also can combine with free exciton for EMP and produce coherent EMP condensation and emission from a nanowire. This kind of nanowires can be expected to work for both spintronic and spin-photonic devices if we tune the transition metal ion doping concentration in it.
ACS Appl Mater Interfaces 2014 Jul 09
PMID:Magnetic exciton relaxation and spin-spin interaction by the time-delayed photoluminescence spectra of ZnO:Mn nanowires. 2491 49

The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronociceptive systems such as substance P. We present evidence to support this hypothesis in this work from the spinal cord in a neuropathic pain model in mice. Biochemical analysis confirmed the elevated mRNA and protein level of pronociceptive substance P, the major endogenous ligand of the neurokinin-1 (NK1) receptor, in the lumbar spinal cord of chronic constriction injury (CCI)-mice. To improve opioid efficacy in neuropathic pain, novel compounds containing opioid agonist and neurokinin 1 (NK1) receptor antagonist pharmacophores were designed. Structure-activity studies were performed on opioid agonist/NK1 receptor antagonist hybrid peptides by modification of the C-terminal amide substituents. All compounds were evaluated for their affinity and in vitro activity at the mu opioid (MOP) and delta opioid (DOP) receptors, and for their affinity and antagonist activity at the NK1 receptor. On the basis of their in vitro profiles, the analgesic properties of two new bifunctional hybrids were evaluated in naive and CCI-mice, representing models for acute and neuropathic pain, respectively. The compounds were administered to the spinal cord by lumbar puncture. In naive mice, the single pharmacophore opioid parent compounds provided better analgesic results, as compared to the hybrids (max 70% MPE), raising the acute pain threshold close to 100% MPE. On the other hand, the opioid parents gave poor analgesic effects under neuropathic pain conditions, while the best hybrid delivered robust (close to 100% MPE) and long lasting alleviation of both tactile and thermal hypersensitivity. The results presented emphasize the potential of opioid/NK1 hybrids in view of analgesia under nerve injury conditions.
ACS Chem Neurosci 2017 10 18
PMID:Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice. 2869 50

Artemisinin has excellent antimalarial, antiparasitic, and antibacterial activities; however, the poor water solubility of artemisinin crystal limits their application in antibiosis. Herein, artemisinin crystal was first composited with silica nanoparticles (SNPs) to form an artemisinin@silica nanoparticle (A@SNP). After treating with nitrogen plasma, the aqueous solubility of plasma-treated A@SNP (A@SNP-p) approaches 42.26%, which is possibly attributed to the exposure of hydrophilic groups such as -OH groups on the SNPs during the plasma process. Compared with the pristine A@SNP, the antibacterial activity of A@SNP-p against both Gram-positive and Gram-negative strains is further enhanced, and its bactericidal rate against both strains exceeded 6 log CFU/mL (>99.9999%), which is contributed by the increased water solubility of the A@SNP-p. A possible multipathway antibacterial mechanism of A@SNP was proposed and preliminarily proved by the changes of intracellular materials of bacteria and the inhibition of bacterial metabolism processes, including the HMP pathway in Gram-negative strain and EMP pathway in Gram-positive strain, after treating with A@SNP-p. These findings from the present work will provide a new view for fabricating artemisinin-based materials as antibiotics.
ACS Appl Mater Interfaces 2019 Dec 18
PMID:Multipathway Antibacterial Mechanism of a Nanoparticle-Supported Artemisinin Promoted by Nitrogen Plasma Treatment. 3179 61