Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.2.1.1 (
ACS
)
78,556
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The dopamine agonist cabergoline has been used to treat prolactinomas, Parkinson's disease, Cushing's disease and
sexual dysfunction
. However, its clinical use was severely curtailed when it was found that patients taking cabergoline had an increased risk of developing cardiac-valve regurgitation. This potentially life-threatening condition has been associated with drugs, such as cabergoline, that are 5-HT
2B
receptor agonists. We prepared analogs of cabergoline and have identified several that have limited or no agonism at the 5-HT
2B
receptor.
ACS
Med Chem Lett 2013 Feb 14
PMID:Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism. 2360 28
