Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.2.1.1 (ACS)
 78,556 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Molecular biologists have long dreamed of switching genes on and off at will in any part of the body during embryonic development. Their dream is now coming true thanks to the transparency of the embryonic body of the zebrafish ( Danio rerio), which has made gene manipulation by photoillumination possible.
ACS Chem Biol 2007 Oct 19
PMID:Yin-yang ways of controlling gene expression are now in our hands. 1804 12

Walking on the water surface is a dream of humans, but it is exactly the way of life for some aquatic insects. In this study, a bionic aquatic microrobot capable of walking on the water surface like a water strider was reported. The novel water strider-like robot consisted of ten superhydrophobic supporting legs, two miniature dc motors, and two actuating legs. The microrobot could not only stand effortlessly but also walk and turn freely on the water surface, exhibiting an interesting motion characteristic. A numerical model describing the interface between the partially submerged leg and the air-water surface was established to fully understand the mechanism for the large supporting force of the leg. It was revealed that the radius and water contact angle of the legs significantly affect the supporting force. Because of its high speed, agility, low cost, and easy fabrication, this microrobot might have a potential application in water quality surveillance, water pollution monitoring, and so on.
ACS Appl Mater Interfaces 2011 Jul
PMID:Bioinspired aquatic microrobot capable of walking on water surface like a water strider. 2165 Apr 60

Chemical biologists commonly seek out correlations between the physicochemical properties of molecules and their behavior in biological systems. However, a new paradigm is emerging for peptides in which conformation is recognized as the primary determinant of bioactivity and bioavailability. This review highlights an emerging body of work that directly addresses how a peptide's conformation controls its biological effects, cell penetration, and intestinal absorption. Based on this work, the dream of mimicking the potency and bioavailability of natural product peptides is getting closer to reality.
ACS Chem Biol 2013 Mar 15
PMID:Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints. 2317 Sep 54

The search for antimalarial remedies predates modern medicine and the concept of small molecule chemotherapy, yet has played a central role in the development of both. This history is reviewed in the context of the current renaissance in antimalarial drug discovery, which is seeing modern drug discovery approaches applied to the problem for the first time. Great strides have been made in the past decade, but further innovations from the drug discovery community will be required if the ultimate dream of eradication is to be achieved.
ACS Med Chem Lett 2013 Dec 12
PMID:Antimalarial Drug Discovery: From Quinine to the Dream of Eradication. 2479 Jul 6

In the past years, scientists have shown that development of a power suit is no longer a dream by integrating the piezoelectric nanogenerator (PENG) or triboelectric nanogenerator (TENG) with commercial carbon fiber cloth. However, there is still no design applying those two kinds of NG together to collect the mechanical energy more efficiently. In this paper, we demonstrate a fiber-based hybrid nanogenerator (FBHNG) composed of TENG and PENG to collect the mechanical energy in the environment. The FBHNG is three-dimensional and can harvest the energy from all directions. The TENG is positioned in the core and covered with PENG as a coaxial core/shell structure. The PENG design here not only enhances the collection efficiency of mechanical energy by a single carbon fiber but also generates electric output when the TENG is not working. We also show the potential that the FBHNG can be weaved into a smart cloth to harvest the mechanical energy from human motions and act as a self-powered strain sensor. The instantaneous output power density of TENG and PENG can achieve 42.6 and 10.2 mW/m(2), respectively. And the rectified output of FBHNG has been applied to charge the commercial capacitor and drive light-emitting diodes, which are also designed as a self-powered alert system.
ACS Nano 2014 Oct 28
PMID:3D fiber-based hybrid nanogenerator for energy harvesting and as a self-powered pressure sensor. 2526 17

Ocean waves are one of the most abundant energy sources on earth, but harvesting such energy is rather challenging due to various limitations of current technologies. Recently, networks formed by triboelectric nanogenerator (TENG) have been proposed as a promising technology for harvesting water wave energy. In this work, a basic unit for the TENG network was studied and optimized, which has a box structure composed of walls made of TENG composed of a wavy-structured Cu-Kapton-Cu film and two FEP thin films, with a metal ball enclosed inside. By combination of the theoretical calculations and experimental studies, the output performances of the TENG unit were investigated for various structural parameters, such as the size, mass, or number of the metal balls. From the viewpoint of theory, the output characteristics of TENG during its collision with the ball were numerically calculated by the finite element method and interpolation method, and there exists an optimum ball size or mass to reach maximized output power and electric energy. Moreover, the theoretical results were well verified by the experimental tests. The present work could provide guidance for structural optimization of wavy-structured TENGs for effectively harvesting water wave energy toward the dream of large-scale blue energy.
ACS Nano 2015 Dec 22
PMID:Structural Optimization of Triboelectric Nanogenerator for Harvesting Water Wave Energy. 2656 54

Four-dimensional ultrafast electron microscopy (4D-UEM) is a novel analytical technique that aims to fulfill the long-held dream of researchers to investigate materials at extremely short spatial and temporal resolutions by integrating the excellent spatial resolution of electron microscopes with the temporal resolution of ultrafast femtosecond laser-based spectroscopy. The ingenious use of pulsed photoelectrons to probe surfaces and volumes of materials enables time-resolved snapshots of the dynamics to be captured in a way hitherto impossible by other conventional techniques. The flexibility of 4D-UEM lies in the fact that it can be used in both the scanning (S-UEM) and transmission (UEM) modes depending upon the type of electron microscope involved. While UEM can be employed to monitor elementary structural changes and phase transitions in samples using real-space mapping, diffraction, electron energy-loss spectroscopy, and tomography, S-UEM is well suited to map ultrafast dynamical events on materials surfaces in space and time. This review provides an overview of the unique features that distinguish these techniques and also illustrates the applications of both S-UEM and UEM to a multitude of problems relevant to materials science and chemistry.
ACS Appl Mater Interfaces 2017 01 11
PMID:Four-Dimensional Ultrafast Electron Microscopy: Insights into an Emerging Technique. 2691 13

The use of solar energy to power chemical reactions is a long-standing dream of the chemical community. Recently, visible-light-mediated photoredox catalysis has been recognized as the ideal catalytic transformation to convert solar energy into chemical bonds. However, scaling photochemical transformations has been extremely challenging due to Bouguer-Lambert-Beer law. Recently, we have pioneered the development of luminescent solar concentrator photomicroreactors (LSC-PMs), which display an excellent energy efficiency. These devices harvest solar energy, convert the broad solar energy spectrum to a narrow-wavelength region, and subsequently waveguide the re-emitted photons to the reaction channels. Herein, we report on the scalability of such LSC-PMs via a numbering-up strategy. Paramount in our work was the use of molds that were fabricated via 3D printing. This allowed us to rapidly produce many different prototypes and to optimize experimentally key design aspects in a time-efficient fashion. Reactors up to 32 parallel channels have been fabricated that display an excellent flow distribution using a bifurcated flow distributor (standard deviations below 10%). This excellent flow distribution was crucial to scale up a model reaction efficiently, displaying yields comparable to those obtained in a single-channel device. We also found that interchannel spacing is an important and unique design parameter for numbered-up LSC-PMs, which influences greatly the photon flux experienced within the reaction channels.
ACS Sustain Chem Eng 2018 Jan 02
PMID:Scale-up of a Luminescent Solar Concentrator-Based Photomicroreactor via Numbering-up. 2933 50

Platinum (Pt)-based materials are inevitably among the best-performing electrocatalysts for hydrogen evolution reaction (HER). MoS2 was suggested to be a potent HER catalyst to replace Pt in this reaction by theoretical modeling; however, in practice, this dream remains elusive. Here we show a facile one-pot bottom-up synthesis of Pt-MoS x composites using electrochemical reduction in an electrolytic bath of Pt precursor and ammonium tetrathiomolybdate under ambient conditions. By modifying the millimolar concentration of Pt precursors, composites of different surface elemental composition are fabricated; specifically, Pt1.8MoS2, Pt0.1MoS2.5, Pt0.2MoS0.6, and Pt0.3MoS0.8. All electrodeposited Pt-MoS x hybrids showcase low overpotentials and small Tafel slopes that outperform MoS2 as an electrocatalyst. Tantamount to electrodeposited Pt, the rate-limiting process in the HER mechanism is determined to be the Heyrovsky desorption across Pt-MoS x hybrids and starkly swings from the rate-determining Volmer adsorption step in MoS2. The Pt-MoS x composites are equipped with catalytic performance that closely mirrors that of electrodeposited Pt, in particular the HER kinetics for Pt1.8MoS2 and Pt0.1MoS2.5. This work advocates electrosynthesis as a cost-effective method for catalyst design and fabrication of competent composite materials for water splitting applications.
ACS Appl Mater Interfaces 2018 Mar 14
PMID:Tunable Pt-MoS x Hybrid Catalysts for Hydrogen Evolution. 2950 38

Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) manifests as unpleasant dreams and dream-enacting behaviors during REM sleep. iRBD is currently recognized as a prodromal stage of Parkinson's disease (PD), and the majority of iRBD patients will develop PD. However, there is an approximately 10 year interval between iRBD onset and established PD, which provides neurologists a window for intervention prior to irreversible neuron damage in prodromal PD patients. In this Review, we summarize possible predictive markers of PD in iRBD on clinical assessment, heredity, neuroimaging, and electrophysiology. We hope this summary can help researchers and clinical physicians better understand the risk factors for conversion from iRBD to PD and indicate directions for neuroprotective strategies and the prediction of disease progression.
ACS Chem Neurosci 2019 02 20
PMID:From Rapid Eye Movement Sleep Behavior Disorder to Parkinson's Disease: Possible Predictive Markers of Conversion. 3022 3


1 2 Next >>