Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.1.1.4 (leucyl-tRNA synthetase)
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Human Gene/Protein
KIAA0028 16.7
leucyl-tRNA synthetase 16.7
Ras-related GTP binding B 16.7
PTCD1 protein 16.7
LARS1 15.7
LeuRS 15.5
LARS2 14.8
Isoleucyl-tRNA synthetase 13.9
HARS2 13.7
Leucyl-tRNA synthetase 13.7
TSH1 13.5
LRS 13.0
RagD 13.0
serS 12.6
ProRS 12.5
valyl-tRNA synthetase 12.4
Seryl-tRNA synthetase 12.3
LARS 12.3
ValRS 12.3
Valyl-tRNA synthetase 12.1
SEMA3C 11.9
RagB 11.8
IleRS 11.6
LIMD1 11.4
paired box protein 11.4
prolyl-tRNA synthetase 11.3
LysRS 11.2
MSL1 11.2
K84 11.0
PAX1 11.0
Arginyl-tRNA synthetase 10.9
RagC 10.9
MSRB1 10.8
FKBP38 10.8
seryl-tRNA synthetase 10.7
arginyl-tRNA synthetase 10.7
CLPP 10.7
methionyl-tRNA synthetase 10.6
MetRS 10.5
RPS14 10.4
asparaginyl-tRNA synthetase 10.3
IRS 10.2
G18 10.1
glutaminyl-tRNA synthetase 10.1
RagA 10.0
Insulin-like growth factor 2 10.0
P49 10.0
AOI 9.9
SFRP5 9.8
threonine deaminase 9.8
RPC 9.7
lysyl-tRNA synthetase 9.6
CEH 9.6
tRNA 9.6
purH 9.5
HSD17B4 9.5
E.coli) 9.5
COXII 9.4
tyrosyl-tRNA synthetase 9.4
Leu2 9.4
eIF-2B 9.3
threonyl-tRNA synthetase 9.3
Leucine-rich repeat kinase 2 9.3
alanyl-tRNA synthetase 9.3
WASH 9.2
histidyl-tRNA synthetase 9.2
TORC1 8.8
ARD 8.8
A14 8.7
A15 8.7
HEXB 8.6
SC1 8.6
oncogene) 8.5
Prion protein 8.5
aldolase C 8.4
MELAS 8.4
cytotoxic T-lymphocyte-associated antigen 4 8.3
Vps34 8.3
p43 8.2
L16 8.2
more...
Disease
LRS1 15.1
CP1 12.4
RPC 9.7
MELAS 8.8
mitochondrial encephalomyopathy 8.7
MELAS 8.5
CAA 8.4
sideroblastic anemia 8.1
CAA 7.9
crown gall 7.6
onychomycosis 7.4
enzyme deficiency 7.3
microcytic anemia 7.2
premature ovarian failure 7.1
hyaline membrane disease 6.8
lactic acidosis 6.3
KPC 6.2
SAD 6.0
giardiasis 6.0
AGA 5.9
kala-azar 5.7
cryptosporidiosis 5.5
African trypanosomiasis 5.2
Mycoplasma 5.2
Turner syndrome 5.0
CEM 4.7
myositis 4.6
CCD 4.5
interstitial lung disease 4.5
metabolic disorder 4.4
CCD 4.4
fungal infection 4.2
Mycobacterium 4.2
acne 4.0
toxoplasmosis 3.9
coagulopathy 3.8
Graves' disease 3.6
acute leukemia 3.6
tuberculosis 3.5
APC 3.4
deafness 3.4
Syndrome 3.3
urinary tract infection 3.2
atopic dermatitis 3.0
dermatitis 3.0
suicide 2.9
colon cancer 2.9
malnutrition 2.9
worms 2.7
mole 2.6
encephalopathy 2.6
pulmonary hypertension 2.5
SARS 2.5
psoriasis 2.4
mole 2.3
Klebsiella 2.3
metabolic syndrome 2.1
SDS 2.1
sarcoma 2.0
hepatitis 1.8
acute myeloid leukemia 1.6
tumor progression 1.4
renal disease 1.2
SEM 1.2
tumorigenesis 0.9
type 2 diabetes 0.9
Parkinson's disease 0.8
carcinogenesis 0.7
cardiovascular disease 0.7
hepatocellular carcinoma 0.6
lung cancer 0.6
stroke 0.5
diabetes -0.4
tumor -1.1
cancer -1.3
Symptom
starvation 5.4
erythema 3.0
functional recovery 3.0
acidity 2.8
Drug
Norvaline 13.3
Zinc sulfate 10.2
Zinc sulfate 10.2
OMP 7.8
AGG 7.1
VCR 6.1
Fragment 5.5
Mutagen 4.2
Ethanol 3.5
lysine 3.2
Gel 2.8
ascorbate 2.2
Enzyme
leucyl-tRNA synthetase 16.7
CobQ 13.5
isoleucyl-tRNA synthetase 12.6
valyl-tRNA synthetase 12.3
proteinase yscB 12.2
prolyl-tRNA synthetase 12.0
8-amino-7-oxononanoate synthase 12.0
seryl-tRNA synthetase 11.0
AICAR transformylase 10.9
CobB 10.8
methionyl-tRNA synthetase 10.7
arginyl-tRNA synthetase 10.6
asparaginyl-tRNA synthetase 10.2
glutaminyl-tRNA synthetase 9.9
phenylalanyl-tRNA synthetase 9.8
lysyl-tRNA synthetase 9.6
glutamyl-tRNA synthetase 9.2
threonine deaminase 9.2
histidyl-tRNA synthetase 9.1
alanyl-tRNA synthetase 9.0
pyruvate oxidase 8.6
pyruvate oxidase 8.6
phosphoglycerate dehydrogenase 8.4
reductoisomerase 8.2
acetate kinase 7.8
TRS 7.7
serine hydroxymethyltransferase 7.5
cysteine synthase 7.4
E-2 7.2
methionine synthase 7.0
acyl-CoA synthetase 7.0
methionine synthase 6.9
cystathionine beta-synthase 6.8
formate dehydrogenase 6.8
formate dehydrogenase 6.8
formate dehydrogenase 6.6
fumarase 6.6
CPS 6.4
acyl-CoA synthetase 6.4
transketolase 6.4
rubisco 6.3
pyruvate carboxylase 6.1
glutamine synthetase 6.0
aconitase 5.9
adenylate kinase 5.8
diaphorase 5.3
isocitrate dehydrogenase 5.1
isocitrate dehydrogenase 5.0
S1 nuclease 4.9
enolase 4.9
subtilisin 4.6
complex I 4.6
citrate synthase 4.6
adenosine deaminase 4.4
adenosine deaminase 4.4
pyruvate kinase 4.4
AMPK 4.1
GSK 4.0
ATP synthase 3.9
RNA polymerase 3.6
AMPK 3.1
acid phosphatase 3.1
AMP-activated protein kinase 3.0
beta-galactosidase 2.9
ACS 2.8
RNase 2.6
endonuclease 2.5
phosphodiesterase 2.5
trypsin 2.3
lactate dehydrogenase 1.9
reverse transcriptase 1.8
protein kinase 0.4
Compound
Granaticin 13.9
Valyl 12.5
Hypoglycin A 12.4
norvaline 11.9
norvaline 11.8
p-Chloroamphetamine 11.0
C56 10.2
Zinc sulfate 10.1
Selenomethionine 8.9
methylguanosine 8.5
CAA 8.3
isoleucine 8.1
isoleucine 8.1
L-leucine 8.0
AIR 8.0
norleucine 8.0
leucine 7.9
tetraphosphate 7.9
Leucine 7.8
OMP 7.7
Carnosine 7.7
HCP 7.6
norleucine 7.6
PPi 7.3
Ile 7.3
valine 7.3
Quinone 7.3
aminomethyl 7.2
LCR 7.0
benzenesulfonamide 7.0
benzenesulfonamide 7.0
benzenesulfonamide 7.0
NTA 7.0
Polypeptide 7.0
adenylate 6.9
SAD 6.8
phenylboronic acid 6.6
UGA 6.6
Rifampicin 5.6
Ciprofloxacin 5.6
EMS 5.6
chromate 5.6
ASC 5.5
Dextran 5.5
boron 5.4
PAC 5.2
DEAE 5.1
homoserine 5.1
homoserine 5.1
homoserine 5.1
Guo 5.1
Rapamycin 5.0
aspartic acid 4.9
aspartic acid 4.9
threonine 4.9
methionine 4.9
GDP 4.8
aspartic acid 4.8
proline 4.7
THE 4.7
MIC 4.7
aspartic acid 4.7
uridine 4.6
UTP 4.5
Guo 4.5
phosphoric acid 4.4
glutamine 4.3
hydrazine 4.3
ATP 4.2
butyric acid 4.2
GTP 4.2
UDP 4.1
PMA 4.1
butyric acid 4.1
pyrimidine 4.0
pyrimidine 4.0
butyric acid 3.9
acetaldehyde 3.9
A 3 3.8
glutamic acid 3.7
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