Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.1.1.20 (phenylalanyl-tRNA synthetase)
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Human Gene/Protein
phenylalanine-tRNA synthetase 16.4
FARSB 16.2
FARS2 15.2
Phenylalanyl-tRNA synthetase 14.9
mitochondrial tryptophanyl-tRNA synthetase 14.4
phenylalanyl tRNA synthetase 13.7
FARS 13.7
MRX9 13.1
DNA-directed RNA polymerase subunit 13.0
threonyl-tRNA synthetase 12.6
FRSA 12.4
RUMT 12.2
IARS 12.2
Seryl-tRNA synthetase 12.0
FTSJ1 11.9
Valyl-tRNA synthetase 11.9
adenylosuccinate synthase 11.8
seryl-tRNA synthetase 11.5
arginyl-tRNA synthetase 11.4
valyl-tRNA synthetase 11.2
TyrRS 11.2
MAF1 10.9
translation initiation factor IF2 10.9
CSF2RA 10.6
alanyl-tRNA synthetase 10.6
aspartyl-tRNA synthetase 10.6
G20 10.4
Inorganic pyrophosphatase 10.3
tryptophanyl-tRNA synthetase 10.2
ACCA 10.2
tyrosyl-tRNA synthetase 10.1
G24 10.1
asparaginyl-tRNA synthetase 10.0
lysyl-tRNA synthetase 10.0
COXI 9.9
cysteinyl-tRNA synthetase 9.9
leucyl-tRNA synthetase 9.9
AGU 9.8
L20 9.8
CMP-sialic acid synthetase 9.8
tRNA 9.6
U19 9.6
glycyl-tRNA synthetase 9.5
spliceosomal protein 9.5
HNA 9.4
G30 9.4
FRS2 9.3
elongation factor Tu 9.3
MARS 9.2
COXII 9.1
yeast) 9.1
methionyl-tRNA synthetase 9.0
histidyl-tRNA synthetase 8.9
LRS 8.8
G15 8.8
glutaminyl-tRNA synthetase 8.8
MERRF 8.8
IRS 8.8
CCL14 8.8
TNS 8.7
MSF 8.6
CCA 8.6
threonine deaminase 8.5
IF2 8.5
EF-Tu 8.5
translation initiation factor 8.5
G10 8.4
U1A 8.1
NPC2 8.1
Dihydrofolate reductase 8.0
RPC 7.8
peptidyl-prolyl cis-trans isomerase 7.7
C40 7.7
DHFR 7.5
FKBP 7.5
LAM 7.5
AMP deaminase 7.4
A15 7.4
pyrophosphatase 7.4
C32 7.3
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Disease
Sampson 10.0
Alpers 10.0
MERRF 8.7
TNS 8.7
MSF 8.6
spastic paraplegia 8.3
RPC 7.8
CAA 7.5
CAA 7.1
MCS 6.9
MCS 6.9
pulmonary alveolar proteinosis 6.7
interstitial lung disease 6.5
AAA 6.5
lymphangioleiomyomatosis 5.8
mitochondrial disease 5.6
Dissociation 5.6
myeloid leukemia 5.5
Niemann-Pick 5.5
encephalopathy 5.5
dermatomyositis 5.4
myositis 5.3
cryptosporidiosis 5.2
disorientation 5.1
Merkel cell carcinoma 5.1
abdominal aortic aneurysm 4.9
African trypanosomiasis 4.9
Charcot-Marie-Tooth disease 4.9
mole 4.9
polymyositis 4.8
mole 4.6
developmental delay 4.4
brain atrophy 4.2
deafness 4.1
status epilepticus 3.6
Mycoplasma 3.6
SAR 3.6
epilepsy 3.3
SDS 2.8
Haemophilus 2.5
chronic myeloid leukemia 2.2
meningitis 2.1
autoimmune disease 1.8
pneumonia 1.7
suicide 1.7
multiple myeloma 1.3
cirrhosis 1.1
malaria 1.0
sepsis 0.6
Parkinson's disease 0.5
hepatocellular carcinoma 0.3
infectious diseases 0.1
cold -0.1
leukemia -0.1
diabetes -0.6
tumor -2.9
cancer -3.6
Symptom
general problem 6.7
hypertonia 6.2
hypotonia 5.5
dysarthria 4.6
tremor 2.3
starvation 1.8
seizures 1.7
anesthesia -0.3
Drug
Fludarabine 7.6
-deoxyadenosine 6.4
L-tyrosine 6.2
ZnCl2 6.1
ZnCl2 6.1
Alanine 6.0
MgSO4 5.9
pyridoxal phosphate 5.1
MRC 4.7
lysine 3.9
Gel 3.6
DNase I 3.4
Asn 2.9
lactose 2.4
ampicillin 2.4
Enzyme
phenylalanyl-tRNA synthetase 16.4
EC 6.1.1.1 13.3
RUMT 11.9
seryl-tRNA synthetase 11.7
arginyl-tRNA synthetase 11.3
valyl-tRNA synthetase 11.2
isoleucyl-tRNA synthetase 11.1
TRS 11.0
aspartyl-tRNA synthetase 10.6
alanyl-tRNA synthetase 10.3
prephenate dehydratase 10.2
threonine synthase 10.2
tryptophanyl-tRNA synthetase 10.1
butyrate kinase 10.0
cysteinyl-tRNA synthetase 10.0
asparaginyl-tRNA synthetase 10.0
lysyl-tRNA synthetase 9.9
glutamyl-tRNA synthetase 9.9
leucyl-tRNA synthetase 9.8
RNase PH 9.8
pyrrolysyl-tRNA synthetase 9.7
RNA ligase 9.6
glycyl-tRNA synthetase 9.5
histidyl-tRNA synthetase 8.9
methionyl-tRNA synthetase 8.8
adenylosuccinate synthetase 8.7
chorismate mutase 8.6
pyruvate:ferredoxin oxidoreductase 8.6
branched-chain aminotransferase 8.6
glutaminyl-tRNA synthetase 8.6
bile salt hydrolase 8.5
levansucrase 8.1
polynucleotide kinase 8.0
threonine deaminase 7.9
methanol dehydrogenase 7.7
dihydrofolate reductase 7.3
AMP deaminase 7.0
MCS 6.8
peptidyl-prolyl cis-trans isomerase 6.8
IMP dehydrogenase 6.6
transpeptidase 5.9
BAL 5.5
sialidase 5.0
acetyl-CoA carboxylase 5.0
RNA polymerase 4.7
S1 nuclease 4.6
proteinase K 4.4
malate dehydrogenase 4.3
pyruvate kinase 4.1
glyceraldehyde-3-phosphate dehydrogenase 4.0
papain 3.8
ATP synthase 3.7
beta-galactosidase 3.6
beta-glucuronidase 3.5
succinate dehydrogenase 3.4
cytochrome oxidase 3.3
alcohol dehydrogenase 3.3
trypsin 2.7
neuraminidase 2.6
RNase 2.4
RNase 2.3
thrombin 1.4
luciferase 1.2
ACS 1.2
Compound
Azure Blue B 16.4
5-bromotryptophan 14.4
Borrelidin 12.0
Borrelidin 12.0
Aurin 11.9
3-(2-naphthyl)alanine 11.7
K 10 11.3
4-methylmorpholine 11.2
Econazole nitrate 11.2
C56 10.5
G20 9.7
Phenylalanine 9.7
tetraphosphate 9.2
PPi 9.0
PHE 8.8
adenylate 8.5
Phe 8.2
CAA 7.4
Ochratoxin A 7.4
2-phenylethylamine 7.1
ENU 6.8
Uridine 6.8
MSG 6.6
AAA 6.5
UGA 6.4
UMP 6.3
Alanine 6.1
Adenine 5.9
Thyroxine 5.9
isoleucine 5.7
Adenosine 5.7
isoleucine 5.7
Dopa 5.7
nitrous acid 5.6
Ile 5.6
AMP 5.5
Tyrosine 5.5
Methionine 5.5
2-mercaptoethanol 5.4
hexadecane 5.4
Penicillin 5.4
DEAE 5.4
betaine 5.2
ATP 5.2
Nitrite 5.2
MgCl2 5.2
L-leucine 5.2
phosphoserine 5.1
Penicillin 5.1
BAL 5.0
Adenine 5.0
Mg2+ 5.0
valine 4.9
naphthalene 4.9
CTP 4.9
homoserine 4.9
homoserine 4.9
homoserine 4.8
trifluoroacetic acid 4.7
trifluoroacetic acid 4.7
trifluoroacetic acid 4.7
trifluoroacetic acid 4.7
trifluoroacetic acid 4.7
PAM 4.5
PAM 4.5
GTP 4.4
uridine 4.4
L-DOPA 4.3
tyrosine 4.3
lysine 4.1
piperazine 4.0
GDP 4.0
acrylamide 4.0
A 1 3.8
alanine 3.8
GlcNAc 3.7
tryptophan 3.7
tryptophan 3.7
Sucrose 3.6
tryptophan 3.6
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