Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:6.1.1.10 (methionyl-tRNA synthetase)
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Human Gene/Protein
methionyl-tRNA synthetase 16.3
MetRS 16.0
MARS2 15.1
IleRS 14.5
ValRS 14.5
GluRS 14.4
EIF-2 14.3
AIMP3 14.3
CysRS 14.2
AsnRS 14.1
LeuRS 13.5
SerRS 13.5
LysRS 13.4
Arginyl-tRNA synthetase 13.4
GlnRS 13.3
HisRS 13.2
Ribonuclease T2 13.2
ribosomal L5 protein 13.2
ThrRS 13.2
ProRS 13.2
AlaRS 13.0
AIMP2 12.7
TyrRS 12.7
AspRS 12.6
Isoleucyl-tRNA synthetase 12.5
cysteinyl-tRNA synthetase 12.4
Glycyl-tRNA synthetase 12.3
IARS 12.1
EPRS 12.1
AIMP1 12.0
Valyl-tRNA synthetase 11.7
RPL37 11.7
prolyl-tRNA synthetase 11.7
methionyl tRNA synthetase 11.7
Phenylalanyl-tRNA synthetase 11.6
valyl-tRNA synthetase 11.4
PAPS synthase 11.4
ribosomal protein L5 11.3
MARS 11.2
tryptophanyl-tRNA synthetase 11.2
tyrosyl-tRNA synthetase 11.1
ATR-interacting protein 11.1
glycyl-tRNA synthetase 11.0
glutaminyl-tRNA synthetase 11.0
arginyl-tRNA synthetase 10.9
lysyl-tRNA synthetase 10.9
KRS 10.8
leucyl-tRNA synthetase 10.8
threonyl-tRNA synthetase 10.5
SRX 10.2
neurolysin 10.1
p43 10.1
aspartyl-tRNA synthetase 10.0
ACCA 10.0
bleomycin hydrolase 10.0
asparaginyl-tRNA synthetase 9.9
IRS 9.9
histidyl-tRNA synthetase 9.8
GARS 9.8
S-adenosylmethionine synthetase 9.8
Holocarboxylase synthetase 9.8
methionine aminopeptidase 9.8
Elongation factor Tu 9.6
peptide deformylase 9.6
eIF-3 9.6
tRNA 9.6
glutamine amidotransferase 9.4
eIF1 9.3
nucleic acid binding protein 9.3
G72 9.1
Methionine adenosyltransferase 9.0
p18 8.9
LRS 8.7
HPII 8.6
CMT2 8.6
MRX 8.5
CCA 8.4
aminopeptidase P 8.4
C35 8.3
G20 8.3
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Disease
CMT2D 12.0
WTS 11.0
Lederer 10.7
CBS deficiency 9.7
KRS 9.5
African trypanosomiasis 7.6
hyperhomocysteinemia 7.5
ERS 6.8
pulmonary alveolar proteinosis 6.6
MTS 6.5
Charcot-Marie-Tooth disease 6.4
Brucella melitensis 5.9
DRS 5.7
trypanosomiasis 5.7
DDP 5.5
cryptosporidiosis 5.1
interstitial lung disease 5.1
Rous sarcoma 4.8
filariasis 4.7
failure to thrive 4.6
thrombocytosis 4.5
bends 4.5
Dissociation 4.4
gangrene 4.4
developmental delay 4.3
anthrax 4.3
MRS 4.1
metabolic disorder 4.0
vascular disease 3.9
PCC 3.8
brucellosis 3.7
ATM 3.7
Mycobacterium 3.7
Mycoplasma 3.5
SAR 3.5
genetic disorder 3.2
cholestasis 3.1
Yersinia 3.1
tuberculosis 2.9
Chlamydia 2.7
atherosclerosis 2.7
leishmaniasis 2.7
pheochromocytoma 2.5
liver disease 2.4
hypothyroidism 2.4
osteosarcoma 2.3
SDS 2.3
worms 2.3
mole 2.2
vasculitis 2.0
mole 2.0
renal cell carcinoma 1.9
neuropathy 1.8
anemia 1.7
colorectal cancer 1.6
myocardial ischemia 1.4
dysplasia 1.3
coronary artery disease 0.9
tumorigenesis 0.5
Parkinson's disease 0.4
carcinogenesis 0.3
myocardial infarction 0.3
stroke 0.2
carcinoma 0.1
breast cancer 0.0
tumor -0.5
HIV -1.1
depression -1.1
cancer -1.1
Symptom
dysesthesia 6.4
hepatomegaly 3.8
starvation 3.7
diarrhea 1.5
headache 0.6
seizures 0.0
Drug
Pyridoxal 8.3
Adenosine deaminase 6.9
lysine 6.0
Vitamin B 6.0
Fraction 6.0
Asn 4.4
CaCl2 3.7
CaCl2 3.7
CaCl2 3.7
Gel 2.5
ampicillin 2.3
NADH 1.9
Enzyme
methionyl-tRNA synthetase 16.3
UDP-N-acetylenolpyruvoylglucosamine reductase 13.0
cysteinyl-tRNA synthetase 12.5
isoleucyl-tRNA synthetase 12.2
tail-specific protease 12.1
glutaminyl-tRNA synthetase 12.1
glutamyl-tRNA synthetase 12.0
prolyl-tRNA synthetase 12.0
methionyl-tRNA formyltransferase 11.9
valyl-tRNA synthetase 11.3
tryptophanyl-tRNA synthetase 11.1
glycyl-tRNA synthetase 10.9
lysyl-tRNA synthetase 10.8
arginyl-tRNA synthetase 10.8
leucyl-tRNA synthetase 10.7
seryl-tRNA synthetase 10.6
peptidyl-tRNA hydrolase 10.6
alanyl-tRNA synthetase 10.6
RNA ligase 10.3
D-serine dehydratase 10.1
aspartyl-tRNA synthetase 10.0
bleomycin hydrolase 10.0
peptide deformylase 10.0
asparaginyl-tRNA synthetase 9.9
histidyl-tRNA synthetase 9.8
neurolysin 9.8
PTR1 9.7
nicotinamidase 9.5
APS kinase 9.5
pyrroline-5-carboxylate dehydrogenase 9.5
sulfiredoxin 9.4
GMP synthetase 9.1
polynucleotide kinase 8.9
TRS 8.9
phenylalanyl-tRNA synthetase 8.8
RNase PH 8.7
alpha-sarcin 8.5
methionine adenosyltransferase 8.5
proline dehydrogenase 8.1
ATP sulfurylase 7.9
3'-exonuclease 7.7
paraoxonase 7.6
venom phosphodiesterase 7.5
cystathionine beta-synthase 7.4
dihydroorotate dehydrogenase 7.4
dihydroorotate dehydrogenase 7.3
paraoxonase 7.3
RNase T1 7.1
acetolactate synthase 7.0
AMP deaminase 6.9
methylenetetrahydrofolate reductase 6.9
methylenetetrahydrofolate reductase 6.9
rhodanese 6.8
chaperonin 6.2
transketolase 6.0
carboxypeptidase Y 6.0
6-phosphogluconate dehydrogenase 5.8
6-phosphogluconate dehydrogenase 5.8
trypsin 5.6
glycerol-3-phosphate dehydrogenase 5.5
RNase 5.5
glycerol-3-phosphate dehydrogenase 5.5
MAP 5.1
RNase 4.7
ribonuclease 4.6
ribonuclease 4.6
S1 nuclease 4.5
glutathione S-transferase 4.5
phosphofructokinase 4.4
subtilisin 4.2
citrate synthase 4.2
dihydrofolate reductase 3.8
phosphodiesterase 3.7
beta-galactosidase 3.5
transcriptase 3.1
chymotrypsin 2.9
beta-lactamase 2.6
lysozyme 1.9
ACS 1.7
RNA polymerase 1.2
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Compound
2-aminoheptanoic acid 14.0
Homocysteine thiolactone 13.5
Prumycin 13.3
3-azaspiro[5.5]undecane 13.3
2-aminooctanoic acid 12.4
4(1H)-quinolinone 11.7
Valyl 11.1
LBF 10.3
fMet 9.9
PPi 9.6
adenylate 9.0
Homocysteine 8.8
Homocysteine 8.8
keto-gamma 8.7
7-methylguanosine 8.7
10-formyltetrahydrofolate 8.6
Selenocysteine 8.4
Pyridoxal 8.3
N-hydroxysuccinimide ester 8.2
O-acetylserine 8.2
homocysteine 8.2
methionine 8.1
O-acetylserine 8.0
Methionine 8.0
G20 7.6
norvaline 7.6
O-acetylserine 7.6
norleucine 7.6
norvaline 7.5
norleucine 7.3
Brilliant Blue 6.9
isoleucine 6.8
isoleucine 6.8
MTS 6.5
tetraphosphate 6.5
Ile 6.4
Yohimbine 6.4
homoserine 6.3
homoserine 6.3
homoserine 6.3
Phenylalanine 6.3
40S 5.9
tellurium 5.8
Agarose 5.8
L-threonine 5.8
DMS 5.7
MgCl2 5.7
lysine 5.6
Biotin 5.6
adenosylmethionine 5.6
Proline 5.5
resorcinol 5.4
aspartic acid 5.3
aspartic acid 5.3
APS 5.3
aspartic acid 5.2
ATP 5.1
valine 5.1
chalcone 5.0
aspartic acid 5.0
uridine 5.0
AMP 5.0
leucine 4.8
Cyt 4.8
proline 4.7
Serine 4.6
ornithine 4.6
ornithine 4.6
ornithine 4.6
ornithine 4.6
ornithine 4.6
MIC 4.5
Mg2+ 4.5
CBS 4.5
glutamine 4.4
PAM 4.4
PAM 4.4
Asp 4.4
2-mercaptoethanol 4.3
glutamic acid 4.3
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