Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:6.1.1.10 (
methionyl-tRNA synthetase
)
387
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Selection of the proper start codon for the synthesis of a polypeptide by the Escherichia coli translation initiation apparatus involves several macromolecular components. These macromolecules interact in a specific and concerted manner to yield the translation initiation complex. This review focuses on recent data concerning the properties of the initiator tRNA and of enzymes and factors involved in the translation initiation process. The three initiation factors, as well as
methionyl-tRNA synthetase
and methionyl-tRNA(f)Met formyltransferase are described. In addition, the tRNA recognition properties of
EF-Tu
and peptidyl-tRNA hydrolase are considered. Finally, peptide deformylase and methionine aminopeptidase, which catalyze the amino terminal maturation of nascent polypeptides, can also be associated to the translation initiation process.
...
PMID:Molecular recognition governing the initiation of translation in Escherichia coli. A review. 895 98
