Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.3 (topoisomerase)
 9,911 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
DNA gyrase 0.102
DNA topoisomerase 0.084
topoisomerase I 0.024
topoisomerase II alpha 0.010
TOP2A 0.008
ICRF 0.006
DNA topoisomerase I 0.006
topoisomerase II beta 0.002
topo II beta 0.002
RMI1 0.002
TOP2B 0.002
TOP1 0.002
type I DNA topoisomerase 0.001
DNA topoisomerase III 0.001
TOP3 0.001
TDP1 0.001
RMI2 0.001
TOP2A protein 0.001
MLL 0.001
Tyrosyl-DNA phosphodiesterase 1 0.001
tyrosyl-DNA phosphodiesterase 1 0.001
TOP1mt 0.001
TOP1MT 0.001
SPO11 0.001
MX2 0.001
P-glycoprotein 0.001
ICB1 0.000
mitochondrial topoisomerase I 0.000
helicase 0.000
ATP 0.000
DNA topoisomerase II beta 0.000
TOP3A 0.000
PICH 0.000
TOP3B 0.000
H2AX 0.000
BLM 0.000
Mariner transposase 0.000
mdr1 0.000
p53 0.000
DNA-dependent protein kinase 0.000
DNA polymerase alpha 0.000
DNA topoisomerase 1 0.000
C9orf82 0.000
DNA helicase 0.000
ICBP90 0.000
MIC 0.000
breakpoint cluster region 0.000
TOP 0.000
MRP 0.000
ATM 0.000
Mol 0.000
SLFN11 0.000
HRX 0.000
AML 0.000
ubiquitin specific peptidase 42 0.000
shugoshin-like 2 0.000
ELOF1 0.000
LIX1L 0.000
MDR1 0.000
P1b 0.000
TOP2 beta 0.000
TTRAP 0.000
TOP1 protein 0.000
Chk1 0.000
DNA polymerase 0.000
DNA ligase 0.000
TDRD3 0.000
irs-2 0.000
MUS81 0.000
poly(ADP-ribose) polymerase 0.000
PARP 0.000
PRRC1 0.000
SFRS7 0.000
human leucocyte antigen A 0.000
CKBBP2 0.000
RBP56/CHN 0.000
exo-alpha-sialidase 0.000
NLRP13 0.000
dedicator of cytokinesis 10 0.000
ATPase 0.000
more...
Disease
cancer 0.001
leukemia 0.000
BLM 0.000
acute myeloid leukemia 0.000
Therapy-related myelodysplastic syndrome 0.000
CEM 0.000
tumor 0.000
L.donovani 0.000
vaccinia 0.000
ATM 0.000
secondary AML 0.000
MCF 0.000
mouse leukemia L1210 0.000
myelodysplastic syndrome 0.000
recurrent PNET 0.000
small cell lung cancer 0.000
WRN 0.000
breast cancer 0.000
MDS 0.000
acute promyelocytic leukemia 0.000
Teratoma with malignant transformation 0.000
Leukemia 0.000
SCAN1 0.000
colon cancer 0.000
acute lymphoblastic leukemia 0.000
lung cancer 0.000
SMC 0.000
ovarian cancer 0.000
lung carcinoma 0.000
acute leukemia 0.000
myeloid leukemia 0.000
carcinoma 0.000
non-small cell lung cancer 0.000
leukemogenesis 0.000
scleroderma 0.000
TAS 0.000
APL 0.000
PSS 0.000
solid tumor 0.000
lymphoma 0.000
childhood ependymoma 0.000
FAB L2 0.000
APL 0.000
Shope fibroma 0.000
adenocarcinoma 0.000
bacterial conjunctivitis 0.000
CREST 0.000
PanIN-1A 0.000
AML/MDS 0.000
MAR 0.000
PanIN-1B 0.000
mouse leukemia P388 0.000
lymphoblastic leukemia 0.000
Axonal Neuropathy 0.000
Drug resistant tuberculosis 0.000
melanoma 0.000
secondary myelodysplastic syndromes 0.000
myelosuppression 0.000
SAR 0.000
urogenital gonorrhea 0.000
Fanconi 0.000
APL 0.000
carcinogenesis 0.000
de novo myelodysplastic syndromes 0.000
neutropenia 0.000
TAM 0.000
glioblastoma 0.000
Idiopathic hypoparathyroidism 0.000
xeroderma pigmentosum 0.000
epithelial ovarian cancer 0.000
amok 0.000
tumor growth 0.000
African swine fever 0.000
FPD/AML 0.000
prostate cancer 0.000
osteosarcoma 0.000
RTS 0.000
colorectal cancer 0.000
childhood ANLL 0.000
glioma 0.000
more...
Symptom
diarrhea 0.000
starvation 0.000
disturbed balance 0.000
ataxia 0.000
collapse 0.000
autodigestion 0.000
No adverse effect 0.000
HSA 0.000
nausea and vomiting 0.000
asthenia 0.000
Halo 0.000
decreased appetite 0.000
ophthalmoplegia 0.000
menopausal symptoms 0.000
nausea 0.000
dyspnea 0.000
apathy 0.000
eds 0.000
Hudson 0.000
hypoproteinemia 0.000
night sweats 0.000
muscle stiffness 0.000
vomiting 0.000
tonic-clonic seizure 0.000
skin damage 0.000
cerebellar ataxia 0.000
incoordination 0.000
chills 0.000
rhinorrhea 0.000
hyperoxia 0.000
dysuria 0.000
splenomegaly 0.000
fatigue 0.000
hoarseness 0.000
bone pain 0.000
colic 0.000
anorexia 0.000
cough 0.000
pelvic pain 0.000
syncope 0.000
hepatosplenomegaly 0.000
headache 0.000
paresthesia 0.000
abdominal pain 0.000
seizures 0.000
hepatomegaly 0.000
erythema 0.000
hypotonia 0.000
weakness 0.000
sleepiness 0.000
functional recovery 0.000
exhaustion 0.000
acidity 0.000
pain 0.000
discomfort 0.000
discomfort 0.000
anesthesia 0.000
Drug
Etoposide 0.004
Dexrazoxane 0.001
CPT-11 0.000
Teniposide 0.000
Adriamycin 0.000
Sobuzoxane 0.000
BLM 0.000
Pixantrone 0.000
TTC 0.000
Irinotecan 0.000
Aclarubicin 0.000
Gemifloxacin 0.000
DNase I 0.000
Gemifloxacin mesylate 0.000
Premafloxacin 0.000
Edotecarin 0.000
ADR 0.000
Sitafloxacin 0.000
MDS 0.000
Podophyllotoxin 0.000
Podophyllum 0.000
Idarubicin 0.000
Moxifloxacin 0.000
Mutagen 0.000
Avelox 0.000
Tetrahydropyran 0.000
Tirapazamine 0.000
Irofulven 0.000
Ilmofosine 0.000
Gluthathione 0.000
PZFX 0.000
Radicicol 0.000
VCR 0.000
Gatifloxacin 0.000
Etoposide phosphate 0.000
1,2,4-Triazole 0.000
Gemzar 0.000
VCR 0.000
Ofloxacin 0.000
Menogaril 0.000
caffeine 0.000
Taxotere 0.000
Asn 0.000
AraC 0.000
Taxol 0.000
Herceptin 0.000
Tarivid 0.000
TEL 0.000
Myricetin 0.000
GEO 0.000
Enrofloxacin 0.000
Epidoxorubicin 0.000
Vorinostat 0.000
Docetaxel 0.000
Polysorbate 20 0.000
Compound 9 0.000
Gadoteridol 0.000
Gliadel 0.000
lysine 0.000
Rauwolfia serpentina 0.000
Vinorelbine 0.000
Xeloda 0.000
Dronedarone 0.000
Navelbine 0.000
ADM 0.000
Novantrone 0.000
Compound 19 0.000
Pirarubicin 0.000
NOV 0.000
ROS 0.000
Compound 16 0.000
Fludarabine 0.000
Vindesine 0.000
Poudre 0.000
Vindesine 0.000
Compound 15 0.000
Glutathione 0.000
Zevalin 0.000
CED 0.000
Gel 0.000
more...
Enzyme
topoisomerase 1.000
topoisomerase 0.910
P-glycoprotein 0.001
DNA polymerase 0.000
EC 5.99.1.1 0.000
DNA ligase 0.000
DNA ligase 0.000
PARP 0.000
ATPase 0.000
endonuclease 0.000
MDR 0.000
thymidylate synthase 0.000
RNA polymerase 0.000
ribonucleotide reductase 0.000
hydroxypyruvate isomerase 0.000
ribonucleotide reductase 0.000
caspase-3 0.000
cdc2 0.000
CPT 0.000
protein kinase 0.000
glutathione S-transferase 0.000
CPT 0.000
caspase-2 0.000
phosphodiesterase 0.000
kallikrein 10 0.000
RNase M5 0.000
CPT 0.000
caspase-2 0.000
polynucleotide kinase 0.000
micrococcal nuclease 0.000
ERK 0.000
DNase 0.000
DNase II 0.000
proteasome 0.000
polo-like kinase 1 0.000
dihydrofolate reductase 0.000
protein kinase C 0.000
nucleoside triphosphate phosphohydrolase 0.000
IMP dehydrogenase 0.000
S-formylglutathione hydrolase 0.000
endonuclease VII 0.000
deoxycytidine kinase 0.000
thymidine kinase 0.000
AP lyase 0.000
separase 0.000
RNase H 0.000
caspase-9 0.000
dCMP hydroxymethylase 0.000
RNase 0.000
dCMP deaminase 0.000
DNA methyltransferase 0.000
dUTPase 0.000
caspase-1 0.000
lambda exonuclease 0.000
RNase 0.000
mitogen-activated protein kinase 0.000
proteinase K 0.000
caspase-8 0.000
enzyme X 0.000
NQO1 0.000
luciferase 0.000
reverse transcriptase 0.000
bleomycin hydrolase 0.000
S1 nuclease 0.000
deoxycytidine deaminase 0.000
exonuclease V 0.000
PIP kinase 0.000
deoxyribonuclease 0.000
STK2 0.000
FabH 0.000
carboxylesterase 0.000
PTR1 0.000
prolyl-tRNA synthetase 0.000
Protein 2 0.000
Escherichia coli exonuclease III 0.000
DSR 0.000
amidophosphoribosyltransferase 0.000
glutamate racemase 0.000
penicillopepsin 0.000
endodeoxyribonuclease 0.000
more...
Compound
m-AMSA 0.014
VP-16 0.009
DNA 0.005
VM-26 0.004
ICRF-187 0.002
Novobiocin 0.001
Camptothecin 0.001
Camptothecin 0.001
Camptothecin 0.001
Merbarone 0.001
Topotecan 0.001
Ellipticine 0.001
Topotecan 0.001
Adriamycin 0.001
SN-38 0.001
CPT-11 0.000
Fostriecin 0.000
Psorospermin 0.000
ATP 0.000
CI-921 0.000
Mitoxantrone 0.000
Mitoxantrone 0.000
ADR 0.000
acridine 0.000
benzo[a]phenazine 0.000
MIC 0.000
2,6-piperazinedione 0.000
BLM 0.000
Clorobiocin 0.000
Genistein 0.000
1,3-bis(4-morpholinylmethyl)-2-imidazolidinethione 0.000
6-bromo-9H-purine 0.000
8-Methoxycaffeine 0.000
C15H12O5 0.000
C15H12O5 0.000
C15H12O5 0.000
C15H12O5 0.000
C15H12O5 0.000
N-ethylhydrazinecarbothioamide 0.000
Podophyllotoxin acetate 0.000
Fagaronine 0.000
C15H12O5 0.000
Kinamycin C 0.000
NMHE 0.000
Elsamicin 0.000
Cryptolepine 0.000
beta-Lapachone 0.000
5H-indeno[1,2-b]pyridin-5-one 0.000
Licodione 0.000
Albamycin 0.000
Usambarensine 0.000
Mitindomide 0.000
C37H40N2O6 0.000
Lunacridine 0.000
abietan-18-oic acid 0.000
Lunacridine 0.000
2-butanone thiosemicarbazone 0.000
Methoxycamptothecin 0.000
2-(dimethylamino)ethyl 0.000
2-(dimethylamino)ethyl 0.000
Nalidixic acid 0.000
Ciprofloxacin 0.000
C19H18O8 0.000
Voacamine 0.000
C2B4 0.000
6-methoxy-5,8-quinolinedione 0.000
MDR 0.000
Sitafloxacin 0.000
Podophyllotoxin 0.000
5,11-dimethyl-6H-pyrido[4,3-b]carbazole 0.000
Podophyllotoxin 0.000
C17H20N2O3 0.000
1-(phenylsulfonyl)-1H-indole 0.000
2-hydroxynaphthoquinone 0.000
tyrosine 0.000
Coumermycin 0.000
benzo[c]phenanthridine 0.000
2-hydroxynaphthoquinone 0.000
ADP-ribose 0.000
benzo[i]phenanthridine 0.000
more...