Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.3 (topoisomerase)
 9,911 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ELOF1 11.6
shugoshin-like 2 11.6
TOP1mt 11.6
Mariner transposase 11.6
LIX1L 11.6
DNA topoisomerase 11.6
ubiquitin specific peptidase 42 11.6
topo II beta 11.4
ICB1 11.2
TOP2A protein 11.1
TOP1MT 11.1
C9orf82 11.1
DNA topoisomerase III 10.9
topoisomerase II beta 10.9
topoisomerase II alpha 10.8
DNA topoisomerase II beta 10.8
DNA gyrase 10.8
RMI2 10.6
SFRS7 10.6
PRRC1 10.6
CKBBP2 10.6
dedicator of cytokinesis 10 10.6
NLRP13 10.6
RBP56/CHN 10.6
mitochondrial topoisomerase I 10.6
TOP2B 10.6
exo-alpha-sialidase 10.6
human leucocyte antigen A 10.6
RMI1 10.6
type I DNA topoisomerase 10.5
TOP3 10.5
ICRF 10.5
TOP2 beta 10.3
TOP1 protein 10.3
TOP3A 10.3
Tyrosyl-DNA phosphodiesterase 1 10.2
TOP2A 10.2
SEPTIN6 10.1
KIAA1210 10.1
Mucosal vascular addressin cell adhesion molecule 1 10.1
MOZ/CBP 10.1
topoisomerase IIb 10.1
irs-2 10.1
TRAF interacting protein 10.1
splicing factor 4 10.1
MGC4175 10.1
TDRD3 10.1
TDP1 10.1
TDP1 protein 10.1
TOP3B 9.9
PICH 9.8
tyrosyl-DNA phosphodiesterase 1 9.7
topoisomerase I 9.7
TGF-beta activated kinase 9.6
cytochrome P450, family 2, subfamily D, polypeptide 6 9.6
Tudor domain-containing protein 3 9.6
DNA topoisomerase I 9.6
TOP1 9.6
TRAF and TNF receptor-associated protein 9.5
FRYL 9.5
DNA topoisomerase 2 9.3
KIAA0020 9.3
ataxin 10 9.3
SFRS4 9.3
Mitotic kinesin-like protein 1 9.3
SNF2, histone-linker, PHD and RING finger domain-containing helicase 9.3
ZNF214 9.3
HZW10 9.3
ICBP90 9.3
TTRAP 9.3
SPO11 9.3
SLFN11 9.2
TAFI110 9.1
SARL 9.1
TGGCA-binding protein 9.1
Cys-X-Cys) 9.1
PMX1 9.1
E1A-like inhibitor of differentiation 3 9.1
myeloid leukemia factor 2 9.1
minichromosome maintenance complex component 4 9.1
more...
Disease
recurrent PNET 10.6
Therapy-related myelodysplastic syndrome 9.6
L.donovani 9.6
Teratoma with malignant transformation 9.1
SCAN1 8.2
mouse leukemia L1210 8.0
FAB L2 7.8
childhood ependymoma 7.8
PanIN-1A 7.5
PanIN-1B 7.4
secondary AML 7.2
Axonal Neuropathy 7.2
Drug resistant tuberculosis 7.1
secondary myelodysplastic syndromes 7.1
mouse leukemia P388 7.1
urogenital gonorrhea 6.9
de novo myelodysplastic syndromes 6.9
Idiopathic hypoparathyroidism 6.7
Shope fibroma 6.7
amok 6.6
BLM 6.6
FPD/AML 6.5
bacterial conjunctivitis 6.5
AML/MDS 6.5
childhood ANLL 6.4
HER-2 positive breast cancer 6.4
adult soft tissue sarcoma 6.3
recurrent SCLC 6.2
Reovirus infection 6.2
CEM 6.1
PanIN-2 6.1
preneoplastic state 6.0
WRN 6.0
limited-stage small cell lung cancer 6.0
Argininosuccinic aciduria 6.0
SMC 5.9
Anaplastic carcinoma 5.8
PanIN-3 5.8
APL 5.8
MDS 5.7
Theileriosis 5.7
APL 5.7
trichomonal vaginitis 5.7
CREST 5.6
TAS 5.6
Subependymomas 5.6
MCPH1 5.6
stage III colorectal cancer 5.5
microbial disease 5.5
metastatic Ewing's sarcoma 5.5
Infection induced 5.5
MAR 5.4
FAB M2 5.3
ABC-DLBCL 5.3
vaccinia 5.3
small cell lung cancer 5.3
metastatic pheochromocytoma 5.2
Alpers 5.2
Cerebral metastases 5.1
RAEB-T 5.1
ATM 5.1
CNS cancer 5.1
RTS 5.1
squamous cell carcinoma of the anus 5.0
recurrent ovarian cancer 5.0
acute undifferentiated leukemia 5.0
in situ breast cancer 4.9
diffuse scleroderma 4.9
myeloid leukemia 4.9
APL 4.9
Gastrointestinal Tumor 4.9
histiocytic lymphoma 4.9
acute monocytic leukemia 4.9
XPF 4.9
MSF 4.8
adenocarcinoma of unknown primary 4.8
ODA 4.8
Craniopharyngioma 4.8
pediatric solid tumor 4.8
myelodysplastic syndrome 4.8
more...
Symptom
disturbed balance 3.8
autodigestion 3.3
No adverse effect 3.3
Halo 2.8
decreased appetite 2.5
HSA 2.4
asthenia 2.3
menopausal symptoms 2.0
ophthalmoplegia 1.9
ataxia 1.6
eds 1.6
Hudson 1.6
nausea and vomiting 1.6
hypoproteinemia 1.5
starvation 1.5
night sweats 1.4
muscle stiffness 1.4
tonic-clonic seizure 1.3
apathy 1.2
diarrhea 1.2
collapse 1.1
skin damage 1.1
incoordination 0.9
cerebellar ataxia 0.8
chills 0.6
rhinorrhea 0.5
nausea 0.5
dysuria 0.4
hyperoxia 0.3
dyspnea 0.2
hoarseness 0.1
bone pain 0.0
colic 0.0
splenomegaly -0.0
vomiting -0.1
pelvic pain -0.3
hepatosplenomegaly -0.5
anorexia -0.5
syncope -0.5
paresthesia -0.6
hepatomegaly -0.9
hypotonia -0.9
cough -0.9
fatigue -1.0
erythema -1.0
abdominal pain -1.3
headache -1.5
seizures -1.8
weakness -2.0
sleepiness -2.0
functional recovery -2.1
exhaustion -2.1
acidity -2.2
discomfort -2.8
discomfort -2.9
pain -3.5
anesthesia -5.1
Drug
Sobuzoxane 11.1
Edotecarin 10.1
Premafloxacin 10.1
Pixantrone 9.6
Gemifloxacin mesylate 9.5
Dexrazoxane 9.3
Etoposide 9.3
Teniposide 9.3
Aclarubicin 9.0
Gemifloxacin 8.5
Sitafloxacin 8.3
Avelox 8.1
Tetrahydropyran 8.1
Ilmofosine 7.9
Gluthathione 7.9
PZFX 7.8
Podophyllotoxin 7.7
Irofulven 7.7
Etoposide phosphate 7.4
1,2,4-Triazole 7.4
CPT-11 7.3
Irinotecan 7.3
Podophyllum 7.3
Tirapazamine 7.2
Radicicol 7.2
BLM 7.1
Idarubicin 7.0
TTC 6.7
Menogaril 6.7
Adriamycin 6.5
Gatifloxacin 6.4
Moxifloxacin 6.4
Tarivid 6.2
Gemzar 6.1
ADR 5.9
Epidoxorubicin 5.9
MDS 5.9
Polysorbate 20 5.8
VCR 5.8
Gadoteridol 5.7
Gliadel 5.6
Rauwolfia serpentina 5.6
Myricetin 5.4
Xeloda 5.4
Compound 9 5.3
Enrofloxacin 5.2
Dronedarone 5.2
Compound 19 5.2
Vorinostat 5.2
Taxotere 5.2
Ofloxacin 5.2
Navelbine 5.1
Pirarubicin 5.1
DNase I 5.0
Novantrone 5.0
Compound 16 4.9
Vinorelbine 4.9
NOV 4.9
TEL 4.8
Vindesine 4.8
AraC 4.8
Poudre 4.8
Vindesine 4.7
VCR 4.7
Compound 15 4.7
Zevalin 4.6
Mutagen 4.6
Fludarabine 4.4
GEO 4.4
Pentostam 4.3
Atovaquone 4.2
Herceptin 4.2
Docetaxel 4.2
Filgrastim 4.2
CED 4.1
Pefloxacin 4.0
Taxol 4.0
Filgrastim 4.0
Flavopiridol 4.0
Diamminedichloroplatinum 3.9
more...
Enzyme
EC 5.99.1.1 11.6
topoisomerase 11.6
topoisomerase 11.6
hydroxypyruvate isomerase 9.1
kallikrein 10 7.8
RNase M5 7.8
S-formylglutathione hydrolase 6.8
nucleoside triphosphate phosphohydrolase 6.6
dCMP hydroxymethylase 6.4
DNA ligase 6.1
DNA ligase 6.1
P-glycoprotein 6.0
endonuclease VII 5.9
DNase II 5.9
caspase-2 5.8
enzyme X 5.8
dCMP deaminase 5.8
AP lyase 5.8
polynucleotide kinase 5.7
caspase-2 5.6
thymidylate synthase 5.6
separase 5.6
lambda exonuclease 5.5
ribonucleotide reductase 5.5
MDR 5.5
dUTPase 5.3
bleomycin hydrolase 5.3
DNA polymerase 5.2
deoxycytidine deaminase 5.2
exonuclease V 5.2
ribonucleotide reductase 5.2
deoxycytidine kinase 5.2
IMP dehydrogenase 5.1
STK2 5.1
PIP kinase 5.0
PTR1 5.0
prolyl-tRNA synthetase 5.0
polo-like kinase 1 5.0
CPT 5.0
FabH 4.9
PARP 4.9
CPT 4.8
Escherichia coli exonuclease III 4.8
DSR 4.7
amidophosphoribosyltransferase 4.7
micrococcal nuclease 4.7
penicillopepsin 4.7
glutamate racemase 4.7
endodeoxyribonuclease 4.6
Protein 2 4.5
deoxyguanosine kinase 4.5
endonuclease 4.5
CPT 4.4
inosine triphosphatase 4.4
pseudouridine synthase 4.3
alanine racemase 4.3
cdc2 4.3
ubiquinol-cytochrome c oxidoreductase 4.3
enoyl-ACP reductase 4.2
3'-phosphatase 4.2
enoyl-ACP reductase 4.2
RNase H 4.2
ScpA 4.2
coproporphyrinogen III oxidase 4.2
pyruvate formate-lyase 4.1
phosphatidylserine decarboxylase 4.0
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.0
3'-exonuclease 4.0
dihydrofolate reductase 4.0
acyl carrier protein synthase 4.0
DNase 4.0
deoxyribonuclease 3.9
aspartase 3.9
GM3 synthase 3.9
poly(A) polymerase 3.9
RNA polymerase 3.8
chitin synthase 3.8
branched-chain aminotransferase 3.8
polyamine oxidase 3.8
iduronate-2-sulfatase 3.7
more...
Compound
C15H12O5 11.6
6-bromo-9H-purine 11.6
C15H12O5 11.6
8-Methoxycaffeine 11.6
C15H12O5 11.6
C15H12O5 11.6
1,3-bis(4-morpholinylmethyl)-2-imidazolidinethione 11.6
N-ethylhydrazinecarbothioamide 11.6
Kinamycin C 11.6
Podophyllotoxin acetate 11.6
C15H12O5 11.6
C15H12O5 11.6
Psorospermin 11.2
Merbarone 10.8
m-AMSA 10.7
C37H40N2O6 10.6
5H-indeno[1,2-b]pyridin-5-one 10.6
Lunacridine 10.6
Licodione 10.6
abietan-18-oic acid 10.6
Lunacridine 10.6
Methoxycamptothecin 10.6
Mitindomide 10.6
Albamycin 10.6
Usambarensine 10.6
2-butanone thiosemicarbazone 10.6
Elsamicin 10.3
benzo[a]phenazine 10.2
Voacamine 10.1
6-methoxy-5,8-quinolinedione 10.1
C19H18O8 10.1
C2B4 10.1
Fostriecin 10.0
Fagaronine 9.9
ICRF-187 9.9
2,6-piperazinedione 9.7
CI-921 9.7
Clorobiocin 9.6
1-(phenylsulfonyl)-1H-indole 9.6
C17H20N2O3 9.6
Ellipticine 9.6
Novobiocin 9.4
VM-26 9.4
benzo[i]phenanthridine 9.3
Moxifloxacin hydrochloride 9.3
11H-indeno[1,2-b]quinoline 9.3
Methanesulfonanilide 9.3
Mulberrofuran G 9.3
5,11-dimethyl-6H-pyrido[4,3-b]carbazole 9.3
Chloroquinoxaline sulfonamide 9.3
11H-indeno[1,2-b]quinoline 9.3
VP-16 9.1
NMHE 9.1
2-hydroxynaphthoquinone 9.1
C14H12O3 9.1
9-cis-Retinal 9.1
Bimolane 9.1
Cryptolepine 9.0
2-hydroxynaphthoquinone 8.9
Pinobanksin 8.8
2,3-dihydro-1H-cyclopenta[b]quinoline 8.8
Rubrofusarin 8.8
Topotecan 8.8
Camptothecin 8.8
beta-Lapachone 8.7
Camptothecin 8.7
Camptothecin 8.7
C18H18N2O5 8.6
Illudin S 8.6
[1,2,4]triazolo[1,5-a]pyridine 8.5
benzo[g]isoquinoline-5,10-dione 8.5
1-methyl-4-piperidinol 8.5
Nogalamycin 8.3
Toxoflavin 8.3
Sitafloxacin 8.3
Topotecan 8.3
Diospyrin 8.2
Wedelolactone 8.2
Cyasorb 8.2
Quinalizarin 8.2
more...