Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:5.99.1.3 (topoisomerase)
9,911 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein DNA gyrase 1854 topoisomerase I 954 Mol 949 DNA topoisomerase 832 ATP 678 Sep 675 p53 400 P-glycoprotein 265 DNA topoisomerase I 263 ATPase 241 TOP2A 228 histone 195 MIC 185 helicase 182 topoisomerase II alpha 171 thymus 170 caspase-3 147 ICRF 145 polypeptide 136 endonuclease 127 NMR 125 MLL 121 DNA polymerase 118 p21 110 PARP 106 H2AX 103 AML 102 Bcl-2 101 telomeric 95 ATM 92 fused 90 Ki-67 88 DNase I 84 DNA-dependent protein kinase 75 Pseudomonas 72 MDR1 71 proteasome 70 poly(ADP-ribose) polymerase 70 HER2 67 TOP1 66 ADP 65 phosphodiesterase 63 SDS 61 tyrosine kinase 61 c-myc 59 Chk1 59 DNA polymerase alpha 58 BLM 58 ATR 58 colon carcinoma 57 DNA helicase 55 ubiquitin 53 BRCA1 51 epidermal growth factor receptor 51 mdr1 51 histone deacetylase 48 thymidylate synthase 47 histone H3 47 bcl-2 46 GST 46 dimeric 46 proliferating cell nuclear antigen 46 Pol 44 GSH 44 RNA polymerase II 44 DNA ligase 42 glutathione S-transferase 42 MRP 42 MX2 42 Fas 41 topoisomerase II beta 41 osteosarcoma 40 MDS 40 lymphoid 40 glycoprotein 40 tumor necrosis factor 40 cytokine 40 ADR 39 ACS 39 estrogen receptor 38 more...

Disease cancer 2558 tumor 1131 leukemia 671 breast cancer 374 acute myeloid leukemia 282 carcinoma 227 MCF 193 lung cancer 175 ATM 138 lymphoma 134 vaccinia 127 myelodysplastic syndrome 126 adenocarcinoma 118 colon cancer 112 ovarian cancer 108 melanoma 103 lung carcinoma 97 acute lymphoblastic leukemia 96 carcinogenesis 94 CEM 91 BLM 89 Leukemia 83 non-small cell lung cancer 82 hepatocellular carcinoma 80 tumor growth 79 prostate cancer 79 small cell lung cancer 77 colorectal cancer 73 metastases 66 Mycobacterium 65 acute promyelocytic leukemia 63 SDS 61 tumorigenesis 60 acute leukemia 59 HIV 56 glioma 55 tuberculosis 54 PSS 52 neutropenia 47 glioblastoma 47 neuroblastoma 47 GSH 44 WRN 44 solid tumor 43 sarcoma 43 osteosarcoma 41 multiple myeloma 40 scleroderma 40 MDS 40 Klebsiella 38 myeloid leukemia 38 anemia 38 Mycoplasma 36 thrombocytopenia 35 epithelial ovarian cancer 35 tumor progression 34 leukemogenesis 34 squamous cell carcinoma 33 cervical cancer 32 infectious diseases 32 SAR 32 gastric cancer 32 Haemophilus 31 immunodeficiency 30 retinoblastoma 30 secondary AML 29 malaria 29 Hodgkin's disease 29 myelosuppression 29 chronic myeloid leukemia 28 leishmaniasis 28 lymphoblastic leukemia 25 cold 25 pneumonia 25 herpes simplex 24 pancreatic cancer 24 Fanconi 23 fibrosarcoma 23 non-Hodgkin's lymphoma 22 bladder cancer 22 more...

Symptom diarrhea 41 starvation 22 collapse 19 ataxia 15 nausea 10 dyspnea 10 vomiting 9 nausea and vomiting 9 fatigue 8 pain 7 seizures 7 headache 6 HSA 5 asthenia 4 ophthalmoplegia 4 cough 4 abdominal pain 4 apathy 3 weakness 3 anorexia 3 splenomegaly 3 menopausal symptoms 2 hyperoxia 2 erythema 2 cerebellar ataxia 2 syncope 2 decreased appetite 2 chills 2 hypotonia 1 hoarseness 1 anesthesia 1 colic 1 night sweats 1 muscle stiffness 1 hepatomegaly 1 acidity 1 bone pain 1 No adverse effect 1 eds 1 Halo 1 autodigestion 1 hepatosplenomegaly 1 disturbed balance 1 Hudson 1 incoordination 1 skin damage 1 sleepiness 1 dysuria 1 exhaustion 1 paresthesia 1 pelvic pain 1 rhinorrhea 1 hypoproteinemia 1 functional recovery 1 discomfort 1 tonic-clonic seizure 1 discomfort 1

Drug Etoposide 220 Adriamycin 127 CPT-11 93 DNase I 84 TTC 61 BLM 58 lysine 58 caffeine 47 Mutagen 45 MDS 40 Irinotecan 40 ADR 39 Dexrazoxane 33 Asn 33 ROS 26 Gel 19 Teniposide 18 Taxol 16 ampicillin 16 CTX 14 VCR 13 Herceptin 13 Gemifloxacin 13 Glutathione 12 ABC 12 Moxifloxacin 12 CTX 11 VCR 11 CTX 11 ADM 11 Docetaxel 10 GEO 10 MAP 10 Dermatol 9 Aclarubicin 9 AraC 9 Podophyllotoxin 9 Ofloxacin 9 Idarubicin 8 Podophyllum 8 Pixantrone 8 ascorbate 7 Cardiovasc 7 TEL 7 Taxotere 7 Alanine 6 Leaf 6 Sitafloxacin 6 G-CSF 5 Gatifloxacin 5 EPI 5 CSF 5 Gemzar 4 Tirapazamine 4 ACT 4 NADH 4 Monit 4 AZT 4 Enrofloxacin 4 IL-2 4 Vorinostat 4 AZT 4 Paraffin 4 Vinorelbine 4 Sobuzoxane 4 Myricetin 4 MRC 4 ETS 4 Ranitidine 3 Gefitinib 3 Fludarabine 3 Ouabain 3 Bortezomib 3 Fluconazole 3 CED 3 Lovastatin 3 Compound 9 3 CDP 3 Gleevec 3 PCP 3 more...

Enzyme topoisomerase 9911 topoisomerase 9094 P-glycoprotein 268 ATPase 247 DNA polymerase 199 RNA polymerase 156 protein kinase 155 ERK 135 endonuclease 127 PARP 123 caspase-3 110 mitogen-activated protein kinase 82 protein kinase C 82 glutathione S-transferase 81 proteasome 71 phosphodiesterase 71 MDR 61 DNA ligase 57 DNA ligase 57 thymidylate synthase 54 cdc2 52 ribonucleotide reductase 43 luciferase 43 RNase 40 reverse transcriptase 39 ACS 39 DNase 37 RNase 34 ribonucleotide reductase 33 CPT 31 CPT 31 CPT 31 peroxidase 30 dihydrofolate reductase 29 thymidine kinase 28 caspase-9 27 focal adhesion kinase 27 catalase 24 trypsin 23 micrococcal nuclease 23 caspase-8 21 caspase-1 21 DNA methyltransferase 20 beta-galactosidase 18 NQO1 17 alkaline phosphatase 17 proteinase K 16 RNase H 16 polo-like kinase 1 15 caspase-2 14 MEK 14 calcineurin 14 caspase-2 12 lactate dehydrogenase 12 beta-lactamase 12 S1 nuclease 12 glutathione peroxidase 12 polynucleotide kinase 11 IMP dehydrogenase 10 kinesin 10 chloramphenicol acetyltransferase 10 carboxylesterase 10 MAP 9 ornithine decarboxylase 8 phosphoinositide 3-kinase 8 CYP3A4 8 APC 8 DNase II 8 deoxycytidine kinase 8 phosphorylase 7 asparaginase 7 phosphatidylinositol 3-kinase 7 glutathione reductase 7 superoxide dismutase 7 hypoxanthine-guanine phosphoribosyltransferase 7 deoxyribonuclease 7 neuraminidase 7 demethylase 7 tyrosinase 7 firefly luciferase 6 more...

Compound DNA 6243 Dec 692 ATP 678 VP-16 537 m-AMSA 268 tyrosine 245 oxygen 233 Clin 221 Adriamycin 208 MIC 185 VM-26 175 salt 169 phosphate 152 hydrogen 134 sodium 127 MTT 126 ADR 124 acridine 121 water 116 serine 112 bromide 104 lysine 101 alanine 93 CPT-11 92 MDA 89 calcium 86 nitrogen 85 Camptothecin 80 Mg2+ 80 Camptothecin 79 Camptothecin 79 arginine 75 Phe 75 SN-38 74 cysteine 72 Asp 71 ADP 68 sulfate 67 ADP 65 ADP 65 SDS 64 leucine 63 BLM 62 MDR 61 threonine 60 quinoline 59 ICRF-187 59 ADP-ribose 58 quinoline 58 copper 56 pyrimidine 56 pyrimidine 56 pyridine 56 Topotecan 55 GSH 55 GSH 55 Novobiocin 55 Topotecan 55 iron 53 Genistein 52 zinc 51 glucose 51 acetate 49 benzene 48 caffeine 47 galactose 43 Ciprofloxacin 42 Mitoxantrone 40 Mitoxantrone 40 ACS 39 ACS 39 His 39 iodine 37 NH2 35 retinoic acid 35 DDP 35 Ile 33 CPT 33 formaldehyde 33 CPT 31 more...

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