Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: EC:5.99.1.3 (topoisomerase)
9,911 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein DNA gyrase 1854 topoisomerase I 954 Mol 949 DNA topoisomerase 832 ATP 678 Sep 675 p53 400 P-glycoprotein 265 DNA topoisomerase I 263 ATPase 241 TOP2A 228 histone 195 MIC 185 helicase 182 topoisomerase II alpha 171 thymus 170 caspase-3 147 ICRF 145 polypeptide 136 endonuclease 127 NMR 125 MLL 121 DNA polymerase 118 p21 110 PARP 106 H2AX 103 AML 102 Bcl-2 101 telomeric 95 ATM 92 fused 90 Ki-67 88 DNase I 84 DNA-dependent protein kinase 75 Pseudomonas 72 MDR1 71 proteasome 70 poly(ADP-ribose) polymerase 70 HER2 67 TOP1 66 more...

Disease cancer 2558 tumor 1131 leukemia 671 breast cancer 374 acute myeloid leukemia 282 carcinoma 227 MCF 193 lung cancer 175 ATM 138 lymphoma 134 vaccinia 127 myelodysplastic syndrome 126 adenocarcinoma 118 colon cancer 112 ovarian cancer 108 melanoma 103 lung carcinoma 97 acute lymphoblastic leukemia 96 carcinogenesis 94 CEM 91 BLM 89 Leukemia 83 non-small cell lung cancer 82 hepatocellular carcinoma 80 prostate cancer 79 tumor growth 79 small cell lung cancer 77 colorectal cancer 73 metastases 66 Mycobacterium 65 acute promyelocytic leukemia 63 SDS 61 tumorigenesis 60 acute leukemia 59 HIV 56 glioma 55 tuberculosis 54 PSS 52 neuroblastoma 47 neutropenia 47 more...

Symptom diarrhea 41 starvation 22 collapse 19 ataxia 15 nausea 10 dyspnea 10 nausea and vomiting 9 vomiting 9 fatigue 8 seizures 7 pain 7 headache 6 HSA 5 asthenia 4 ophthalmoplegia 4 abdominal pain 4 cough 4 apathy 3 anorexia 3 weakness 3 splenomegaly 3 erythema 2 hyperoxia 2 syncope 2 cerebellar ataxia 2 menopausal symptoms 2 decreased appetite 2 chills 2 hypotonia 1 hoarseness 1 anesthesia 1 colic 1 night sweats 1 muscle stiffness 1 hepatomegaly 1 acidity 1 bone pain 1 No adverse effect 1 eds 1 Halo 1 more...

Drug Etoposide 220 Adriamycin 127 CPT-11 93 DNase I 84 TTC 61 lysine 58 BLM 58 caffeine 47 Mutagen 45 Irinotecan 40 MDS 40 ADR 39 Asn 33 Dexrazoxane 33 ROS 26 Gel 19 Teniposide 18 ampicillin 16 Taxol 16 CTX 14 VCR 13 Gemifloxacin 13 Herceptin 13 Moxifloxacin 12 ABC 12 Glutathione 12 ADM 11 CTX 11 CTX 11 VCR 11 Docetaxel 10 GEO 10 MAP 10 Ofloxacin 9 Aclarubicin 9 Podophyllotoxin 9 AraC 9 Dermatol 9 Idarubicin 8 Pixantrone 8 more...

Enzyme topoisomerase 9911 topoisomerase 9094 P-glycoprotein 268 ATPase 247 DNA polymerase 199 RNA polymerase 156 protein kinase 155 ERK 135 endonuclease 127 PARP 123 caspase-3 110 mitogen-activated protein kinase 82 protein kinase C 82 glutathione S-transferase 81 proteasome 71 phosphodiesterase 71 MDR 61 DNA ligase 57 DNA ligase 57 thymidylate synthase 54 cdc2 52 ribonucleotide reductase 43 luciferase 43 RNase 40 reverse transcriptase 39 ACS 39 DNase 37 RNase 34 ribonucleotide reductase 33 CPT 31 CPT 31 CPT 31 peroxidase 30 dihydrofolate reductase 29 thymidine kinase 28 focal adhesion kinase 27 caspase-9 27 catalase 24 micrococcal nuclease 23 trypsin 23 more...

Compound DNA 6243 Dec 692 ATP 678 VP-16 537 m-AMSA 268 tyrosine 245 oxygen 233 Clin 221 Adriamycin 208 MIC 185 VM-26 175 salt 169 phosphate 152 hydrogen 134 sodium 127 MTT 126 ADR 124 acridine 121 water 116 serine 112 bromide 104 lysine 101 alanine 93 CPT-11 92 MDA 89 calcium 86 nitrogen 85 Camptothecin 80 Mg2+ 80 Camptothecin 79 Camptothecin 79 arginine 75 Phe 75 SN-38 74 cysteine 72 Asp 71 ADP 68 sulfate 67 ADP 65 ADP 65 more...

---