Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.3 (topoisomerase)
 9,911 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ELOF1 11.6
shugoshin-like 2 11.6
Mariner transposase 11.6
ubiquitin specific peptidase 42 11.6
DNA topoisomerase 11.6
LIX1L 11.6
TOP1mt 11.6
topo II beta 11.4
ICB1 11.2
TOP2A protein 11.1
C9orf82 11.1
TOP1MT 11.1
DNA topoisomerase III 10.9
topoisomerase II beta 10.9
topoisomerase II alpha 10.8
DNA topoisomerase II beta 10.8
DNA gyrase 10.8
CKBBP2 10.6
RBP56/CHN 10.6
NLRP13 10.6
more...
Disease
recurrent PNET 10.6
Therapy-related myelodysplastic syndrome 9.6
L.donovani 9.6
Teratoma with malignant transformation 9.1
SCAN1 8.2
mouse leukemia L1210 8.0
FAB L2 7.8
childhood ependymoma 7.8
PanIN-1A 7.5
PanIN-1B 7.4
secondary AML 7.2
Axonal Neuropathy 7.2
Drug resistant tuberculosis 7.1
secondary myelodysplastic syndromes 7.1
mouse leukemia P388 7.1
urogenital gonorrhea 6.9
de novo myelodysplastic syndromes 6.9
Idiopathic hypoparathyroidism 6.7
Shope fibroma 6.7
amok 6.6
more...
Symptom
disturbed balance 3.8
autodigestion 3.3
No adverse effect 3.3
Halo 2.8
decreased appetite 2.5
HSA 2.4
asthenia 2.3
menopausal symptoms 2.0
ophthalmoplegia 1.9
ataxia 1.6
eds 1.6
Hudson 1.6
nausea and vomiting 1.6
hypoproteinemia 1.5
starvation 1.5
night sweats 1.4
muscle stiffness 1.4
tonic-clonic seizure 1.3
apathy 1.2
diarrhea 1.2
more...
Drug
Sobuzoxane 11.1
Premafloxacin 10.1
Edotecarin 10.1
Pixantrone 9.6
Gemifloxacin mesylate 9.5
Dexrazoxane 9.3
Etoposide 9.3
Teniposide 9.3
Aclarubicin 9.0
Gemifloxacin 8.5
Sitafloxacin 8.3
Avelox 8.1
Tetrahydropyran 8.1
Gluthathione 7.9
Ilmofosine 7.9
PZFX 7.8
Podophyllotoxin 7.7
Irofulven 7.7
1,2,4-Triazole 7.4
Etoposide phosphate 7.4
more...
Enzyme
EC 5.99.1.1 11.6
topoisomerase 11.6
topoisomerase 11.6
hydroxypyruvate isomerase 9.1
kallikrein 10 7.8
RNase M5 7.8
S-formylglutathione hydrolase 6.8
nucleoside triphosphate phosphohydrolase 6.6
dCMP hydroxymethylase 6.4
DNA ligase 6.1
DNA ligase 6.1
P-glycoprotein 6.0
endonuclease VII 5.9
DNase II 5.9
caspase-2 5.8
enzyme X 5.8
dCMP deaminase 5.8
AP lyase 5.8
polynucleotide kinase 5.7
caspase-2 5.6
more...
Compound
C15H12O5 11.6
N-ethylhydrazinecarbothioamide 11.6
1,3-bis(4-morpholinylmethyl)-2-imidazolidinethione 11.6
C15H12O5 11.6
6-bromo-9H-purine 11.6
C15H12O5 11.6
C15H12O5 11.6
Podophyllotoxin acetate 11.6
Kinamycin C 11.6
8-Methoxycaffeine 11.6
C15H12O5 11.6
C15H12O5 11.6
Psorospermin 11.2
Merbarone 10.8
m-AMSA 10.7
Lunacridine 10.6
5H-indeno[1,2-b]pyridin-5-one 10.6
Methoxycamptothecin 10.6
Albamycin 10.6
abietan-18-oic acid 10.6
more...