Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.3 (topoisomerase)
 9,911 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
DNA gyrase 1854
topoisomerase I 954
Mol 949
DNA topoisomerase 832
ATP 678
Sep 675
p53 400
P-glycoprotein 265
DNA topoisomerase I 263
ATPase 241
TOP2A 228
histone 195
MIC 185
helicase 182
topoisomerase II alpha 171
thymus 170
caspase-3 147
ICRF 145
polypeptide 136
endonuclease 127
more...
Disease
cancer 2558
tumor 1131
leukemia 671
breast cancer 374
acute myeloid leukemia 282
carcinoma 227
MCF 193
lung cancer 175
ATM 138
lymphoma 134
vaccinia 127
myelodysplastic syndrome 126
adenocarcinoma 118
colon cancer 112
ovarian cancer 108
melanoma 103
lung carcinoma 97
acute lymphoblastic leukemia 96
carcinogenesis 94
CEM 91
more...
Symptom
diarrhea 41
starvation 22
collapse 19
ataxia 15
nausea 10
dyspnea 10
nausea and vomiting 9
vomiting 9
fatigue 8
pain 7
seizures 7
headache 6
HSA 5
abdominal pain 4
ophthalmoplegia 4
cough 4
asthenia 4
apathy 3
anorexia 3
weakness 3
more...
Drug
Etoposide 220
Adriamycin 127
CPT-11 93
DNase I 84
TTC 61
BLM 58
lysine 58
caffeine 47
Mutagen 45
MDS 40
Irinotecan 40
ADR 39
Asn 33
Dexrazoxane 33
ROS 26
Gel 19
Teniposide 18
Taxol 16
ampicillin 16
CTX 14
more...
Enzyme
topoisomerase 9911
topoisomerase 9094
P-glycoprotein 268
ATPase 247
DNA polymerase 199
RNA polymerase 156
protein kinase 155
ERK 135
endonuclease 127
PARP 123
caspase-3 110
protein kinase C 82
mitogen-activated protein kinase 82
glutathione S-transferase 81
proteasome 71
phosphodiesterase 71
MDR 61
DNA ligase 57
DNA ligase 57
thymidylate synthase 54
more...
Compound
DNA 6243
Dec 692
ATP 678
VP-16 537
m-AMSA 268
tyrosine 245
oxygen 233
Clin 221
Adriamycin 208
MIC 185
VM-26 175
salt 169
phosphate 152
hydrogen 134
sodium 127
MTT 126
ADR 124
acridine 121
water 116
serine 112
more...