Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:5.99.1.3 (topoisomerase)
9,911 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein DNA gyrase 1854 topoisomerase I 954 Mol 949 DNA topoisomerase 832 ATP 678 Sep 675 p53 400 P-glycoprotein 265 DNA topoisomerase I 263 ATPase 241 TOP2A 228 histone 195 MIC 185 helicase 182 topoisomerase II alpha 171 thymus 170 caspase-3 147 ICRF 145 polypeptide 136 endonuclease 127 NMR 125 MLL 121 DNA polymerase 118 p21 110 PARP 106 H2AX 103 AML 102 Bcl-2 101 telomeric 95 ATM 92 fused 90 Ki-67 88 DNase I 84 DNA-dependent protein kinase 75 Pseudomonas 72 MDR1 71 proteasome 70 poly(ADP-ribose) polymerase 70 HER2 67 TOP1 66 ADP 65 phosphodiesterase 63 tyrosine kinase 61 SDS 61 Chk1 59 c-myc 59 ATR 58 DNA polymerase alpha 58 BLM 58 colon carcinoma 57 DNA helicase 55 ubiquitin 53 epidermal growth factor receptor 51 mdr1 51 BRCA1 51 histone deacetylase 48 thymidylate synthase 47 histone H3 47 dimeric 46 GST 46 bcl-2 46 proliferating cell nuclear antigen 46 GSH 44 Pol 44 RNA polymerase II 44 DNA ligase 42 MX2 42 glutathione S-transferase 42 MRP 42 Fas 41 topoisomerase II beta 41 MDS 40 tumor necrosis factor 40 osteosarcoma 40 cytokine 40 lymphoid 40 glycoprotein 40 ADR 39 ACS 39 cytochrome c 38 estrogen receptor 38 nuclear protein 37 threonine 37 A-T 37 Gen 37 RMI1 36 annexin V 35 Chk2 35 cyclin B1 35 collagen 34 cyclin 34 histone H1 34 phosphatase 34 cyclin D1 33 EGFR 33 ribonucleotide reductase 33 caspase-9 33 promyelocytic leukemia 32 integrase 32 SAR 32 multidrug resistance-associated protein 32 breakpoint cluster region 32 CPT 31 TOP2B 31 cytochrome P450 31 PI3K 31 erbB-2 30 AML1 30 MAPK 29 ras 29 ABCC1 29 vascular endothelial growth factor 28 TOP 28 TDP1 28 SPO11 28 P-gp 28 RAD51 28 thymidine kinase 28 RNase 28 AMP 27 AKT 27 type I DNA topoisomerase 27 GTP 26 mer 26 dihydrofolate reductase 26 Rad51 26 MIB 26 cyclin A 26 p27 26 serum albumin 26 ROS 26 ataxia telangiectasia mutated 26 neu 25 caspase-8 25 RNA polymerase I 25 mTOR 25 PC-3 25 p38 25 ALL 25 protein tyrosine kinase 25 WAF1 25 TNF 24 p16 24 alpha isoform 23 tyrosyl-DNA phosphodiesterase 1 23 Rad50 23 PARP1 23 cyclin-dependent kinase 23 VEGF 23 MRP1 22 ara 22 metallothionein 22 topo II beta 22 DNA binding protein 22 WRN 22 proteasome inhibitor 22 LRP 22 A431 21 SMC 21 DNA-binding protein 21 more...

Disease cancer 2558 tumor 1131 leukemia 671 breast cancer 374 acute myeloid leukemia 282 carcinoma 227 MCF 193 lung cancer 175 ATM 138 lymphoma 134 vaccinia 127 myelodysplastic syndrome 126 adenocarcinoma 118 colon cancer 112 ovarian cancer 108 melanoma 103 lung carcinoma 97 acute lymphoblastic leukemia 96 carcinogenesis 94 CEM 91 BLM 89 Leukemia 83 non-small cell lung cancer 82 hepatocellular carcinoma 80 prostate cancer 79 tumor growth 79 small cell lung cancer 77 colorectal cancer 73 metastases 66 Mycobacterium 65 acute promyelocytic leukemia 63 SDS 61 tumorigenesis 60 acute leukemia 59 HIV 56 glioma 55 tuberculosis 54 PSS 52 neutropenia 47 neuroblastoma 47 glioblastoma 47 GSH 44 WRN 44 sarcoma 43 solid tumor 43 osteosarcoma 41 multiple myeloma 40 scleroderma 40 MDS 40 Klebsiella 38 myeloid leukemia 38 anemia 38 Mycoplasma 36 thrombocytopenia 35 epithelial ovarian cancer 35 leukemogenesis 34 tumor progression 34 squamous cell carcinoma 33 cervical cancer 32 infectious diseases 32 SAR 32 gastric cancer 32 Haemophilus 31 immunodeficiency 30 retinoblastoma 30 secondary AML 29 malaria 29 Hodgkin's disease 29 myelosuppression 29 leishmaniasis 28 chronic myeloid leukemia 28 lymphoblastic leukemia 25 pneumonia 25 cold 25 pancreatic cancer 24 herpes simplex 24 Fanconi 23 fibrosarcoma 23 bladder cancer 22 non-Hodgkin's lymphoma 22 SMC 21 Epstein 21 AIDS 21 renal cell carcinoma 20 DDP 19 erythroleukemia 19 liver cancer 19 chronic lymphocytic leukemia 19 B-cell lymphoma 18 suicide 18 liver cancer 18 MRSA 18 xeroderma pigmentosum 18 brain tumor 18 systemic lupus erythematosus 18 virus infection 17 PDB 16 TAS 16 TAM 15 dysplasia 15 PML 15 metastatic breast cancer 15 primary tumor 15 testicular cancer 15 sepsis 14 leukopenia 14 mammary tumor 14 hematologic malignancies 14 autism 13 Burkitt's lymphoma 13 gonococcal 13 cardiomyopathy 13 APL 13 APL 13 African swine fever 13 APL 13 Infection 12 glioblastoma multiforme 12 mouse leukemia L1210 12 mole 12 MAR 12 heart failure 12 Ewing's sarcoma 12 pancytopenia 12 multiple sclerosis 12 CTX 11 neuropathy 11 CREST 11 childhood cancer 11 hepatitis B 11 rhabdomyosarcoma 11 endometrial cancer 11 blast crisis 10 autoimmune disease 10 ABL 10 smallpox 10 renal cancer 10 pulmonary fibrosis 10 histiocytic lymphoma 10 APC 10 connective tissue disease 9 chronic lymphocytic leukemia 9 interstitial lung disease 9 WT1 9 schizophrenia 9 meningitis 9 genetic disorder 9 Blocking 9 cytomegalovirus 9 congestive heart failure 9 childhood ALL 9 sepsis 9 Hepatocellular carcinoma 8 skin cancer 8 African trypanosomiasis 8 aggressiveness 8 Chlamydia 8 SCID 8 Fanconi syndrome 8 histiocytic lymphoma 8 more...

Symptom diarrhea 41 starvation 22 collapse 19 ataxia 15 nausea 10 dyspnea 10 vomiting 9 nausea and vomiting 9 fatigue 8 pain 7 seizures 7 headache 6 HSA 5 asthenia 4 ophthalmoplegia 4 cough 4 abdominal pain 4 apathy 3 weakness 3 anorexia 3 splenomegaly 3 menopausal symptoms 2 hyperoxia 2 erythema 2 cerebellar ataxia 2 syncope 2 decreased appetite 2 chills 2 hypotonia 1 hoarseness 1 anesthesia 1 colic 1 night sweats 1 muscle stiffness 1 hepatomegaly 1 acidity 1 bone pain 1 No adverse effect 1 eds 1 Halo 1 autodigestion 1 hepatosplenomegaly 1 disturbed balance 1 Hudson 1 incoordination 1 skin damage 1 sleepiness 1 dysuria 1 exhaustion 1 paresthesia 1 pelvic pain 1 rhinorrhea 1 hypoproteinemia 1 functional recovery 1 discomfort 1 tonic-clonic seizure 1 discomfort 1

Drug Etoposide 220 Adriamycin 127 CPT-11 93 DNase I 84 TTC 61 BLM 58 lysine 58 caffeine 47 Mutagen 45 MDS 40 Irinotecan 40 ADR 39 Dexrazoxane 33 Asn 33 ROS 26 Gel 19 Teniposide 18 Taxol 16 ampicillin 16 CTX 14 Herceptin 13 VCR 13 Gemifloxacin 13 Moxifloxacin 12 Glutathione 12 ABC 12 ADM 11 CTX 11 CTX 11 VCR 11 MAP 10 Docetaxel 10 GEO 10 Aclarubicin 9 AraC 9 Dermatol 9 Podophyllotoxin 9 Ofloxacin 9 Idarubicin 8 Pixantrone 8 Podophyllum 8 Taxotere 7 ascorbate 7 Cardiovasc 7 TEL 7 Sitafloxacin 6 Alanine 6 Leaf 6 EPI 5 Gatifloxacin 5 G-CSF 5 CSF 5 Tirapazamine 4 ACT 4 NADH 4 Enrofloxacin 4 Monit 4 MRC 4 Sobuzoxane 4 ETS 4 Vorinostat 4 Gemzar 4 AZT 4 Vinorelbine 4 IL-2 4 AZT 4 Myricetin 4 Paraffin 4 Ranitidine 3 -deoxyadenosine 3 Fludarabine 3 Gefitinib 3 Ouabain 3 Compound 9 3 PCP 3 Radicicol 3 Bortezomib 3 Fluconazole 3 Lovastatin 3 Gleevec 3 CED 3 CDP 3 lactose 2 AMC 2 Dihydro 2 Sorafenib 2 Gemifloxacin mesylate 2 NaI 2 CaCl2 2 CaCl2 2 Photofrin 2 Itraconazole 2 Avelox 2 CoCl2 2 Irofulven 2 FLP 2 G418 2 CoCl2 2 NaI 2 CAM 2 CaCl2 2 Filgrastim 2 Emodin 2 Novantrone 2 Emodin 2 Xeloda 2 L-tyrosine 2 Bevacizumab 2 Fraction 2 Filgrastim 2 Fragment 2 p75 2 NaI 2 NaI 2 Meth 2 Cremophor EL 2 CFS 2 NH3 2 Doxycycline 2 NOV 2 Dronedarone 2 TAC 2 Navelbine 2 Compound 19 1 Pemetrexed 1 Zoledronic acid 1 DPA 1 Compound 15 1 Gadoteridol 1 Rauwolfia serpentina 1 HCH 1 Phosphatidylserine 1 Azithromycin 1 CTC 1 balanced salt solution 1 Poudre 1 Zoledronic acid 1 Artesunate 1 Glucantime 1 NovoSeven 1 Rituximab 1 Retinoic acid 1 IFN-gamma 1 IL-11 1 MOF 1 Gelatin 1 Fluorescein 1 R1881 1 Gliadel 1 Retinoic Acid 1 Forskolin 1 MTC 1 AGG 1 Meropenem 1 Dakar 1 Dasatinib 1 Angiotensin II 1 Premafloxacin 1 FeCl3 1 ROC 1 more...

Enzyme topoisomerase 9911 topoisomerase 9094 P-glycoprotein 268 ATPase 247 DNA polymerase 199 RNA polymerase 156 protein kinase 155 ERK 135 endonuclease 127 PARP 123 caspase-3 110 mitogen-activated protein kinase 82 protein kinase C 82 glutathione S-transferase 81 proteasome 71 phosphodiesterase 71 MDR 61 DNA ligase 57 DNA ligase 57 thymidylate synthase 54 cdc2 52 luciferase 43 ribonucleotide reductase 43 RNase 40 ACS 39 reverse transcriptase 39 DNase 37 RNase 34 ribonucleotide reductase 33 CPT 31 CPT 31 CPT 31 peroxidase 30 dihydrofolate reductase 29 thymidine kinase 28 focal adhesion kinase 27 caspase-9 27 catalase 24 micrococcal nuclease 23 trypsin 23 caspase-8 21 caspase-1 21 DNA methyltransferase 20 beta-galactosidase 18 alkaline phosphatase 17 NQO1 17 proteinase K 16 RNase H 16 polo-like kinase 1 15 MEK 14 caspase-2 14 calcineurin 14 glutathione peroxidase 12 beta-lactamase 12 S1 nuclease 12 caspase-2 12 lactate dehydrogenase 12 polynucleotide kinase 11 chloramphenicol acetyltransferase 10 kinesin 10 carboxylesterase 10 IMP dehydrogenase 10 MAP 9 CYP3A4 8 phosphoinositide 3-kinase 8 deoxycytidine kinase 8 ornithine decarboxylase 8 DNase II 8 APC 8 neuraminidase 7 asparaginase 7 demethylase 7 phosphatidylinositol 3-kinase 7 phosphorylase 7 hypoxanthine-guanine phosphoribosyltransferase 7 glutathione reductase 7 superoxide dismutase 7 deoxyribonuclease 7 tyrosinase 7 ribonuclease 6 ribonuclease 6 acetylcholinesterase 6 carbonic anhydrase 6 protein phosphatase 2A 6 IKK 6 AMPK 6 transcriptase 6 cathepsin B 6 ATP synthase 6 firefly luciferase 6 histone acetyltransferase 5 chymotrypsin 5 beta-glucuronidase 5 separase 5 dUTPase 5 deoxyribonuclease 5 alanine aminotransferase 5 succinate dehydrogenase 5 histidine kinase 4 creatine kinase 4 chitin synthase 4 AP lyase 4 dipeptidyl peptidase IV 4 alcohol dehydrogenase 4 TdT 4 aspartate aminotransferase 4 endonuclease VII 4 phospholipase C 4 thioredoxin reductase 4 chaperonin 4 N-acetyltransferase 3 lysozyme 3 PCP 3 caspase-7 3 CD13 3 caspase-7 3 dihydropyrimidine dehydrogenase 3 lambda exonuclease 3 glyceraldehyde-3-phosphate dehydrogenase 3 glyceraldehyde-3-phosphate dehydrogenase 3 glyceraldehyde-3-phosphate dehydrogenase 3 Alternating 3 MMP 3 Protein 2 3 sialidase 3 dihydropyrimidine dehydrogenase 3 acid phosphatase 3 diaphorase 3 CD10 3 glyceraldehyde-3-phosphate dehydrogenase 3 cathepsin D 3 glucose-6-phosphate dehydrogenase 3 glyceraldehyde-3-phosphate dehydrogenase 3 thymidine phosphorylase 3 cathepsin L 3 cytidine deaminase 3 poly(A) polymerase 3 thrombin 3 NADPH oxidase 3 GSK 3 aldehyde dehydrogenase 3 complex I 3 dCMP deaminase 3 ACE 3 GCA 2 tryptophan 2,3-dioxygenase 2 lipoxygenase 2 ubiquitin-protein ligase 2 Rex 2 polyamine oxidase 2 cysteine synthase 2 PST 2 tissue plasminogen activator 2 plasmin 2 urokinase-type plasminogen activator 2 MTD 2 farnesyltransferase 2 prostate-specific antigen 2 PIP kinase 2 FabH 2 more...

Compound DNA 6243 Dec 692 ATP 678 VP-16 537 m-AMSA 268 tyrosine 245 oxygen 233 Clin 221 Adriamycin 208 MIC 185 VM-26 175 salt 169 phosphate 152 hydrogen 134 sodium 127 MTT 126 ADR 124 acridine 121 water 116 serine 112 bromide 104 lysine 101 alanine 93 CPT-11 92 MDA 89 calcium 86 nitrogen 85 Mg2+ 80 Camptothecin 80 Camptothecin 79 Camptothecin 79 arginine 75 Phe 75 SN-38 74 cysteine 72 Asp 71 ADP 68 sulfate 67 ADP 65 ADP 65 SDS 64 leucine 63 BLM 62 MDR 61 threonine 60 ICRF-187 59 quinoline 59 ADP-ribose 58 quinoline 58 pyrimidine 56 copper 56 pyrimidine 56 pyridine 56 Novobiocin 55 Topotecan 55 GSH 55 GSH 55 Topotecan 55 iron 53 Genistein 52 zinc 51 glucose 51 acetate 49 benzene 48 caffeine 47 galactose 43 Ciprofloxacin 42 Mitoxantrone 40 Mitoxantrone 40 ACS 39 His 39 ACS 39 iodine 37 NH2 35 retinoic acid 35 DDP 35 CPT 33 Ile 33 formaldehyde 33 CPT 31 potassium 30 methionine 29 EDTA 29 Ellipticine 29 EDTA 29 fluorine 28 Gly 28 AMP 28 hydroquinone 27 GTP 27 formaldehyde 27 dUTP 26 PEG 26 Hoechst 33342 26 naphthoquinone 25 naphthoquinone 25 naphthoquinone 25 naphthoquinone 25 naphthoquinone 25 naphthoquinone 25 naphthoquinone 25 2-(dimethylamino)ethyl 24 dATP 24 TNF 24 2-(dimethylamino)ethyl 24 5-FU 23 glutamate 22 methyl methanesulfonate 22 manganese 22 proline 21 DMSO 21 piperazine 21 MgCl2 20 NAD 20 chlorine 19 3-aminobenzamide 19 anthracene 19 chalcone 19 glycerol 19 nitric oxide 18 NAD 18 isoquinoline 18 ethanol 18 Merbarone 18 N-acetylcysteine 18 H2O2 18 THP 17 C-3 17 phenol 17 Vinca 17 cyanide 16 PEG 16 BCNU 16 Ara-C 16 PDB 16 THP 16 Nalidixic acid 16 methanol 16 ammonium 15 HCl 15 Cu(II) 15 tryptophan 15 methane 15 glutamine 14 urea 14 CTX 14 myricetin 14 Resveratrol 14 CAM 14 Verapamil 13 DEAE 13 nickel 13 Verapamil 13 thiophene 13 Curcumin 12 Fostriecin 12 Benzene 12 aniline 12 cAMP 12 thiourea 12 more...

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