Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:5.99.1.3 (
topoisomerase
)
9,911
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The Myc-associated zinc-finger protein,
Miz1
, activates transcription of the p21cip1 gene in response to UV irradiation.
Miz1
associates with
topoisomerase
II binding protein1 (TopBP1), an essential activator of the Atr kinase. We show here that
Miz1
is required for the recruitment of a fraction of TopBP1 to chromatin, for the protection of TopBP1 from proteasomal degradation and for Atr-dependent signal transduction. TopBP1 that is not bound to chromatin is degraded by the HectH9 (Mule, ARF-BP1 and HUWE1) ubiquitin ligase. Myc antagonizes the binding of TopBP1 to
Miz1
; as a result, expression of Myc leads to dissociation of TopBP1 from chromatin, reduces the amount of total TopBP1 and attenuates Atr-dependent signal transduction. Our data show that
Miz1
and Myc affect the activity of the Atr checkpoint through their effect on TopBP1 chromatin association and stability.
...
PMID:Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1. 1892 29
